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Immunohistochemical localization of vascular endothelial growth factor (VEGF) and its two receptors (Flt-I and KDR) in the endometrium and placenta of the mare during the oestrous cycle and pregnancy.
Reprod Domest Anim. 2007 Oct; 42(5):516-26.RD

Abstract

Polyclonal antisera for vascular endothelial growth factor (VEGF) and its two main receptor molecules, VEGF-I (Flt) and VEGF-II (KDR), were used in a conventional immunocytochemical staining method to localize these angiogenic ligand molecules in the endometrium and placenta of the mare during the oestrous cycle and pregnancy. The anti-VEGF and anti-Flt sera both labelled the lumenal and glandular epithelia of the endometrium throughout the oestrous cycle and both the invasive trophoblast cells of the endometrial cups and the non-invasive trophoblast of the allantochorion in pregnancy. The anti-KDR serum likewise stained the maternal and foetal epithelial layers during the oestrous cycle and pregnancy and it also labelled fibroblast-like cells in the endometrial and allantoic stromas and the endothelium of foetal and maternal capillaries. The results demonstrated that constant supplies of the principal vasculogenic and angiogenic factor, VEGF, and its two major receptors, Flt and KDR, are available on both the maternal and foetal sides of the placental barrier throughout gestation in the mare. They are presumed to facilitate the continuing development of the extensive foetal and maternal capillary networks that are such prominent features within the microplacentomes of the diffuse, epitheliochorial equine placenta.

Authors+Show Affiliations

Department of Veterinary Medicine Equine Fertility Unit, University of Cambridge, Mertoun Paddocks, Woodditton Road, Newmarket, Suffolk, UK. efu@tesco.netNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17845608

Citation

Allen, W R., et al. "Immunohistochemical Localization of Vascular Endothelial Growth Factor (VEGF) and Its Two Receptors (Flt-I and KDR) in the Endometrium and Placenta of the Mare During the Oestrous Cycle and Pregnancy." Reproduction in Domestic Animals = Zuchthygiene, vol. 42, no. 5, 2007, pp. 516-26.
Allen WR, Gower S, Wilsher S. Immunohistochemical localization of vascular endothelial growth factor (VEGF) and its two receptors (Flt-I and KDR) in the endometrium and placenta of the mare during the oestrous cycle and pregnancy. Reprod Domest Anim. 2007;42(5):516-26.
Allen, W. R., Gower, S., & Wilsher, S. (2007). Immunohistochemical localization of vascular endothelial growth factor (VEGF) and its two receptors (Flt-I and KDR) in the endometrium and placenta of the mare during the oestrous cycle and pregnancy. Reproduction in Domestic Animals = Zuchthygiene, 42(5), 516-26.
Allen WR, Gower S, Wilsher S. Immunohistochemical Localization of Vascular Endothelial Growth Factor (VEGF) and Its Two Receptors (Flt-I and KDR) in the Endometrium and Placenta of the Mare During the Oestrous Cycle and Pregnancy. Reprod Domest Anim. 2007;42(5):516-26. PubMed PMID: 17845608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical localization of vascular endothelial growth factor (VEGF) and its two receptors (Flt-I and KDR) in the endometrium and placenta of the mare during the oestrous cycle and pregnancy. AU - Allen,W R, AU - Gower,S, AU - Wilsher,S, PY - 2007/9/12/pubmed PY - 2007/12/6/medline PY - 2007/9/12/entrez SP - 516 EP - 26 JF - Reproduction in domestic animals = Zuchthygiene JO - Reprod Domest Anim VL - 42 IS - 5 N2 - Polyclonal antisera for vascular endothelial growth factor (VEGF) and its two main receptor molecules, VEGF-I (Flt) and VEGF-II (KDR), were used in a conventional immunocytochemical staining method to localize these angiogenic ligand molecules in the endometrium and placenta of the mare during the oestrous cycle and pregnancy. The anti-VEGF and anti-Flt sera both labelled the lumenal and glandular epithelia of the endometrium throughout the oestrous cycle and both the invasive trophoblast cells of the endometrial cups and the non-invasive trophoblast of the allantochorion in pregnancy. The anti-KDR serum likewise stained the maternal and foetal epithelial layers during the oestrous cycle and pregnancy and it also labelled fibroblast-like cells in the endometrial and allantoic stromas and the endothelium of foetal and maternal capillaries. The results demonstrated that constant supplies of the principal vasculogenic and angiogenic factor, VEGF, and its two major receptors, Flt and KDR, are available on both the maternal and foetal sides of the placental barrier throughout gestation in the mare. They are presumed to facilitate the continuing development of the extensive foetal and maternal capillary networks that are such prominent features within the microplacentomes of the diffuse, epitheliochorial equine placenta. SN - 0936-6768 UR - https://www.unboundmedicine.com/medline/citation/17845608/Immunohistochemical_localization_of_vascular_endothelial_growth_factor__VEGF__and_its_two_receptors__Flt_I_and_KDR__in_the_endometrium_and_placenta_of_the_mare_during_the_oestrous_cycle_and_pregnancy_ L2 - https://doi.org/10.1111/j.1439-0531.2006.00815.x DB - PRIME DP - Unbound Medicine ER -