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Depressive symptoms and hypomagnesemia in older diabetic subjects.

Abstract

BACKGROUND

We undertook this study to assess the hypothesis that hypomagnesemia is associated with depressive symptoms in older people with diabetes.

METHODS

A total of 55 type 2 diabetic patients, aged 65 years or older, with depressive symptoms were compared with a control group of diabetic subjects without depressive symptoms in an age- and gender-matched case/control study. A score >or=11 points in the Yesavage's scale was used for defining depressive symptoms, and hypomagnesemia was defined by serum magnesium levels <0.74 mmol/L. Well-known causes for depression as well as diseases and drugs that may cause depressive symptoms or hypomagnesemia were exclusion criteria.

RESULTS

Serum magnesium levels were significantly lower among depressive than control diabetic subjects (0.74 +/- 0.25 vs. 0.86 +/- 0.29 mmol/L, p = 0.02). Twenty four (43.6%) and 7 (12.7%) individuals in the case and control group exhibited low serum magnesium levels (p = 0.0006). The adjusted logistic regression analysis showed an independent association between hypomagnesemia and depressive symptoms (OR 1.79; CI(95%) 1.1-6.9, p = 0.03).

CONCLUSIONS

Our results suggest that hypomagnesemia is independently associated with depressive symptoms in older people with diabetes.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute (IMSS), Durango, Mexico.

    ,

    Source

    Archives of medical research 38:7 2007 Oct pg 752-6

    MeSH

    Aged
    Aged, 80 and over
    Case-Control Studies
    Depression
    Diabetes Mellitus, Type 2
    Female
    Humans
    Magnesium
    Magnesium Deficiency
    Male
    Regression Analysis

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17845894

    Citation

    Barragan-Rodríguez, Lázaro, et al. "Depressive Symptoms and Hypomagnesemia in Older Diabetic Subjects." Archives of Medical Research, vol. 38, no. 7, 2007, pp. 752-6.
    Barragan-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Depressive symptoms and hypomagnesemia in older diabetic subjects. Arch Med Res. 2007;38(7):752-6.
    Barragan-Rodríguez, L., Rodríguez-Morán, M., & Guerrero-Romero, F. (2007). Depressive symptoms and hypomagnesemia in older diabetic subjects. Archives of Medical Research, 38(7), pp. 752-6.
    Barragan-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Depressive Symptoms and Hypomagnesemia in Older Diabetic Subjects. Arch Med Res. 2007;38(7):752-6. PubMed PMID: 17845894.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Depressive symptoms and hypomagnesemia in older diabetic subjects. AU - Barragan-Rodríguez,Lázaro, AU - Rodríguez-Morán,Martha, AU - Guerrero-Romero,Fernando, Y1 - 2007/05/16/ PY - 2006/12/22/received PY - 2007/03/14/accepted PY - 2007/9/12/pubmed PY - 2007/12/6/medline PY - 2007/9/12/entrez SP - 752 EP - 6 JF - Archives of medical research JO - Arch. Med. Res. VL - 38 IS - 7 N2 - BACKGROUND: We undertook this study to assess the hypothesis that hypomagnesemia is associated with depressive symptoms in older people with diabetes. METHODS: A total of 55 type 2 diabetic patients, aged 65 years or older, with depressive symptoms were compared with a control group of diabetic subjects without depressive symptoms in an age- and gender-matched case/control study. A score >or=11 points in the Yesavage's scale was used for defining depressive symptoms, and hypomagnesemia was defined by serum magnesium levels <0.74 mmol/L. Well-known causes for depression as well as diseases and drugs that may cause depressive symptoms or hypomagnesemia were exclusion criteria. RESULTS: Serum magnesium levels were significantly lower among depressive than control diabetic subjects (0.74 +/- 0.25 vs. 0.86 +/- 0.29 mmol/L, p = 0.02). Twenty four (43.6%) and 7 (12.7%) individuals in the case and control group exhibited low serum magnesium levels (p = 0.0006). The adjusted logistic regression analysis showed an independent association between hypomagnesemia and depressive symptoms (OR 1.79; CI(95%) 1.1-6.9, p = 0.03). CONCLUSIONS: Our results suggest that hypomagnesemia is independently associated with depressive symptoms in older people with diabetes. SN - 0188-4409 UR - https://www.unboundmedicine.com/medline/citation/17845894/Depressive_symptoms_and_hypomagnesemia_in_older_diabetic_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(07)00125-7 DB - PRIME DP - Unbound Medicine ER -