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Depressive symptoms and hypomagnesemia in older diabetic subjects.
Arch Med Res 2007; 38(7):752-6AM

Abstract

BACKGROUND

We undertook this study to assess the hypothesis that hypomagnesemia is associated with depressive symptoms in older people with diabetes.

METHODS

A total of 55 type 2 diabetic patients, aged 65 years or older, with depressive symptoms were compared with a control group of diabetic subjects without depressive symptoms in an age- and gender-matched case/control study. A score >or=11 points in the Yesavage's scale was used for defining depressive symptoms, and hypomagnesemia was defined by serum magnesium levels <0.74 mmol/L. Well-known causes for depression as well as diseases and drugs that may cause depressive symptoms or hypomagnesemia were exclusion criteria.

RESULTS

Serum magnesium levels were significantly lower among depressive than control diabetic subjects (0.74 +/- 0.25 vs. 0.86 +/- 0.29 mmol/L, p = 0.02). Twenty four (43.6%) and 7 (12.7%) individuals in the case and control group exhibited low serum magnesium levels (p = 0.0006). The adjusted logistic regression analysis showed an independent association between hypomagnesemia and depressive symptoms (OR 1.79; CI(95%) 1.1-6.9, p = 0.03).

CONCLUSIONS

Our results suggest that hypomagnesemia is independently associated with depressive symptoms in older people with diabetes.

Authors+Show Affiliations

Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute (IMSS), Durango, Mexico.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17845894

Citation

Barragan-Rodríguez, Lázaro, et al. "Depressive Symptoms and Hypomagnesemia in Older Diabetic Subjects." Archives of Medical Research, vol. 38, no. 7, 2007, pp. 752-6.
Barragan-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Depressive symptoms and hypomagnesemia in older diabetic subjects. Arch Med Res. 2007;38(7):752-6.
Barragan-Rodríguez, L., Rodríguez-Morán, M., & Guerrero-Romero, F. (2007). Depressive symptoms and hypomagnesemia in older diabetic subjects. Archives of Medical Research, 38(7), pp. 752-6.
Barragan-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Depressive Symptoms and Hypomagnesemia in Older Diabetic Subjects. Arch Med Res. 2007;38(7):752-6. PubMed PMID: 17845894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms and hypomagnesemia in older diabetic subjects. AU - Barragan-Rodríguez,Lázaro, AU - Rodríguez-Morán,Martha, AU - Guerrero-Romero,Fernando, Y1 - 2007/05/16/ PY - 2006/12/22/received PY - 2007/03/14/accepted PY - 2007/9/12/pubmed PY - 2007/12/6/medline PY - 2007/9/12/entrez SP - 752 EP - 6 JF - Archives of medical research JO - Arch. Med. Res. VL - 38 IS - 7 N2 - BACKGROUND: We undertook this study to assess the hypothesis that hypomagnesemia is associated with depressive symptoms in older people with diabetes. METHODS: A total of 55 type 2 diabetic patients, aged 65 years or older, with depressive symptoms were compared with a control group of diabetic subjects without depressive symptoms in an age- and gender-matched case/control study. A score >or=11 points in the Yesavage's scale was used for defining depressive symptoms, and hypomagnesemia was defined by serum magnesium levels <0.74 mmol/L. Well-known causes for depression as well as diseases and drugs that may cause depressive symptoms or hypomagnesemia were exclusion criteria. RESULTS: Serum magnesium levels were significantly lower among depressive than control diabetic subjects (0.74 +/- 0.25 vs. 0.86 +/- 0.29 mmol/L, p = 0.02). Twenty four (43.6%) and 7 (12.7%) individuals in the case and control group exhibited low serum magnesium levels (p = 0.0006). The adjusted logistic regression analysis showed an independent association between hypomagnesemia and depressive symptoms (OR 1.79; CI(95%) 1.1-6.9, p = 0.03). CONCLUSIONS: Our results suggest that hypomagnesemia is independently associated with depressive symptoms in older people with diabetes. SN - 0188-4409 UR - https://www.unboundmedicine.com/medline/citation/17845894/Depressive_symptoms_and_hypomagnesemia_in_older_diabetic_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(07)00125-7 DB - PRIME DP - Unbound Medicine ER -