Tags

Type your tag names separated by a space and hit enter

To drink or not to drink? That is the question.

Abstract

Numerous studies have used a J-shaped or U-shaped curve to describe the relationship between alcohol use and total mortality. The nadir of the curves based on recent meta-analysis suggested optimal benefit at approximately half a drink per day. Fewer than 4 drinks per day in men and fewer than 2 per day in women appeared to confer benefit. Reductions in cardiovascular death and nonfatal myocardial infarction were also associated with light to moderate alcohol intake. Although some studies suggested that wine had an advantage over other types of alcoholic beverages, other studies suggested that the type of drink was not important. Heavy drinking was associated with an increase in mortality, hypertension, alcoholic cardiomyopathy, cancer, and cerebrovascular events, including cerebrovascular hemorrhage. Paradoxically, light-to-moderate alcohol use actually reduced the development of heart failure and did not appear to exacerbate it in most patients who had underlying heart failure. Numerous mechanisms have been proposed to explain the benefit that light-to-moderate alcohol intake has on the heart, including an increase of high-density lipoprotein cholesterol, reduction in plasma viscosity and fibrinogen concentration, increase in fibrinolysis, decrease in platelet aggregation, improvement in endothelial function, reduction of inflammation, and promotion of antioxidant effects. Controversy exists on whether alcohol has a direct cardioprotective effect on ischemic myocardium. Studies from our laboratory do not support the concept that alcohol has a direct cardioprotective effect on ischemic/reperfused myocardium. Perhaps the time has come for a prospectively randomized trial to determine whether 1 drink per day (or perhaps 1 drink every other day) reduces mortality and major cardiovascular events.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd, Los Angeles, CA 90017, USA. rkloner@goodsam.org

    Source

    Circulation 116:11 2007 Sep 11 pg 1306-17

    MeSH

    Alcohol Drinking
    Alcoholic Beverages
    Cardiovascular Diseases
    Humans
    Risk Factors
    Wine

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    17846344

    Citation

    Kloner, Robert A., and Shereif H. Rezkalla. "To Drink or Not to Drink? That Is the Question." Circulation, vol. 116, no. 11, 2007, pp. 1306-17.
    Kloner RA, Rezkalla SH. To drink or not to drink? That is the question. Circulation. 2007;116(11):1306-17.
    Kloner, R. A., & Rezkalla, S. H. (2007). To drink or not to drink? That is the question. Circulation, 116(11), pp. 1306-17.
    Kloner RA, Rezkalla SH. To Drink or Not to Drink? That Is the Question. Circulation. 2007 Sep 11;116(11):1306-17. PubMed PMID: 17846344.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - To drink or not to drink? That is the question. AU - Kloner,Robert A, AU - Rezkalla,Shereif H, PY - 2007/9/12/pubmed PY - 2007/10/12/medline PY - 2007/9/12/entrez SP - 1306 EP - 17 JF - Circulation JO - Circulation VL - 116 IS - 11 N2 - Numerous studies have used a J-shaped or U-shaped curve to describe the relationship between alcohol use and total mortality. The nadir of the curves based on recent meta-analysis suggested optimal benefit at approximately half a drink per day. Fewer than 4 drinks per day in men and fewer than 2 per day in women appeared to confer benefit. Reductions in cardiovascular death and nonfatal myocardial infarction were also associated with light to moderate alcohol intake. Although some studies suggested that wine had an advantage over other types of alcoholic beverages, other studies suggested that the type of drink was not important. Heavy drinking was associated with an increase in mortality, hypertension, alcoholic cardiomyopathy, cancer, and cerebrovascular events, including cerebrovascular hemorrhage. Paradoxically, light-to-moderate alcohol use actually reduced the development of heart failure and did not appear to exacerbate it in most patients who had underlying heart failure. Numerous mechanisms have been proposed to explain the benefit that light-to-moderate alcohol intake has on the heart, including an increase of high-density lipoprotein cholesterol, reduction in plasma viscosity and fibrinogen concentration, increase in fibrinolysis, decrease in platelet aggregation, improvement in endothelial function, reduction of inflammation, and promotion of antioxidant effects. Controversy exists on whether alcohol has a direct cardioprotective effect on ischemic myocardium. Studies from our laboratory do not support the concept that alcohol has a direct cardioprotective effect on ischemic/reperfused myocardium. Perhaps the time has come for a prospectively randomized trial to determine whether 1 drink per day (or perhaps 1 drink every other day) reduces mortality and major cardiovascular events. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17846344/To_drink_or_not_to_drink_That_is_the_question_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.106.678375?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -