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The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22.

Abstract

OBJECTIVE

To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS).

METHODS

Demographic, lifestyle, and medical characteristics were ascertained on 4519 AREDS participants aged 60 to 80 years at enrollment. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with < 15 small drusen). Nutrient intake was estimated from a self-administered semiquantitative food frequency questionnaire at enrollment. Intake values were energy adjusted and classified by quintiles. The relationship between diet and AMD status was assessed using logistic regression analyses.

RESULTS

Dietary lutein/zeaxanthin intake was inversely associated with neovascular AMD (odds ratio [OR], 0.65; 95% confidence interval [CI], 0.45-0.93), geographic atrophy (OR, 0.45; 95% CI, 0.24-0.86), and large or extensive intermediate drusen (OR, 0.73; 95% CI, 0.56-0.96), comparing the highest vs lowest quintiles of intake, after adjustment for total energy intake and nonnutrient-based covariates. Other nutrients were not independently related to AMD.

CONCLUSION

Higher dietary intake of lutein/zeaxanthin was independently associated with decreased likelihood of having neovascular AMD, geographic atrophy, and large or extensive intermediate drusen.

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  • Authors+Show Affiliations

    ,

    The EMMES Corporation, 401 N Washington St, Ste 700, Rockville, MD 20850-1707, USA. aredspub@emmes.com

    , , , , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Ascorbic Acid
    Carotenoids
    Case-Control Studies
    Choroidal Neovascularization
    Diet
    Eating
    Energy Intake
    Feeding Behavior
    Female
    Humans
    Lutein
    Macular Degeneration
    Male
    Middle Aged
    Nutrition Surveys
    Regression Analysis
    Surveys and Questionnaires
    Vitamin A
    Vitamin E
    Xanthophylls
    Zeaxanthins

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17846363

    Citation

    Age-Related Eye Disease Study Research Group, et al. "The Relationship of Dietary Carotenoid and Vitamin A, E, and C Intake With Age-related Macular Degeneration in a Case-control Study: AREDS Report No. 22." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 125, no. 9, 2007, pp. 1225-32.
    Age-Related Eye Disease Study Research Group, SanGiovanni JP, Chew EY, et al. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007;125(9):1225-32.
    SanGiovanni, J. P., Chew, E. Y., Clemons, T. E., Ferris, F. L., Gensler, G., Lindblad, A. S., ... Sperduto, R. D. (2007). The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Archives of Ophthalmology (Chicago, Ill. : 1960), 125(9), pp. 1225-32.
    Age-Related Eye Disease Study Research Group, et al. The Relationship of Dietary Carotenoid and Vitamin A, E, and C Intake With Age-related Macular Degeneration in a Case-control Study: AREDS Report No. 22. Arch Ophthalmol. 2007;125(9):1225-32. PubMed PMID: 17846363.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. AU - ,, AU - SanGiovanni,John Paul, AU - Chew,Emily Y, AU - Clemons,Traci E, AU - Ferris,Frederick L,3rd AU - Gensler,Gary, AU - Lindblad,Anne S, AU - Milton,Roy C, AU - Seddon,Johanna M, AU - Sperduto,Robert D, PY - 2007/9/12/pubmed PY - 2007/10/5/medline PY - 2007/9/12/entrez SP - 1225 EP - 32 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 125 IS - 9 N2 - OBJECTIVE: To evaluate the relationship of dietary carotenoids, vitamin A, alpha-tocopherol, and vitamin C with prevalent age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS). METHODS: Demographic, lifestyle, and medical characteristics were ascertained on 4519 AREDS participants aged 60 to 80 years at enrollment. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with < 15 small drusen). Nutrient intake was estimated from a self-administered semiquantitative food frequency questionnaire at enrollment. Intake values were energy adjusted and classified by quintiles. The relationship between diet and AMD status was assessed using logistic regression analyses. RESULTS: Dietary lutein/zeaxanthin intake was inversely associated with neovascular AMD (odds ratio [OR], 0.65; 95% confidence interval [CI], 0.45-0.93), geographic atrophy (OR, 0.45; 95% CI, 0.24-0.86), and large or extensive intermediate drusen (OR, 0.73; 95% CI, 0.56-0.96), comparing the highest vs lowest quintiles of intake, after adjustment for total energy intake and nonnutrient-based covariates. Other nutrients were not independently related to AMD. CONCLUSION: Higher dietary intake of lutein/zeaxanthin was independently associated with decreased likelihood of having neovascular AMD, geographic atrophy, and large or extensive intermediate drusen. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/17846363/The_relationship_of_dietary_carotenoid_and_vitamin_A_E_and_C_intake_with_age_related_macular_degeneration_in_a_case_control_study:_AREDS_Report_No__22_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.125.9.1225 DB - PRIME DP - Unbound Medicine ER -