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Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana.
Molecules. 2007 Feb 28; 12(2):263-70.M

Abstract

One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-beta-D-glucopyranosyloxy-4',5-dihydroxy-3-[O-alpha-L-rhamnopyranosyl-(1-->6)-3-O-beta-D-glucopyranosyloxy]flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker's synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5.

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Authors+Show Affiliations

Fiorentino A
Dipartimento di Scienze della Vita, Seconda Università degli Studi di Napoli, I-81100 Caserta, Italy. antonio.fiorentino@unina2.it
D'Abrosca B
No affiliation info available
Pacifico S
No affiliation info available
Golino A
No affiliation info available
Mastellone C
No affiliation info available
Oriano P
No affiliation info available
Monaco P
No affiliation info available

MeSH

AntioxidantsDisaccharidesFlavonesFlavonoidsFlavonolsFree Radical ScavengersGlycosidesKaempferolsMagnetic Resonance SpectroscopyMass SpectrometryMelilotusMonosaccharidesPlant ExtractsQuercetinReactive Oxygen SpeciesRutin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17846577

Citation

Fiorentino, Antonio, et al. "Reactive Oxygen Species Scavenging Activity of Flavone Glycosides From Melilotus Neapolitana." Molecules (Basel, Switzerland), vol. 12, no. 2, 2007, pp. 263-70.
Fiorentino A, D'Abrosca B, Pacifico S, et al. Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana. Molecules. 2007;12(2):263-70.
Fiorentino, A., D'Abrosca, B., Pacifico, S., Golino, A., Mastellone, C., Oriano, P., & Monaco, P. (2007). Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana. Molecules (Basel, Switzerland), 12(2), 263-70.
Fiorentino A, et al. Reactive Oxygen Species Scavenging Activity of Flavone Glycosides From Melilotus Neapolitana. Molecules. 2007 Feb 28;12(2):263-70. PubMed PMID: 17846577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana. AU - Fiorentino,Antonio, AU - D'Abrosca,Brigida, AU - Pacifico,Severina, AU - Golino,Annunziata, AU - Mastellone,Claudio, AU - Oriano,Palma, AU - Monaco,Pietro, Y1 - 2007/02/28/ PY - 2007/01/21/received PY - 2007/02/13/revised PY - 2007/02/27/accepted PY - 2007/9/12/pubmed PY - 2007/10/24/medline PY - 2007/9/12/entrez SP - 263 EP - 70 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 12 IS - 2 N2 - One new and six known flavone glycosides were isolated from the MeOH extract of Melilotus neapolitana Ten. The new compound, identified as 7-O-beta-D-glucopyranosyloxy-4',5-dihydroxy-3-[O-alpha-L-rhamnopyranosyl-(1-->6)-3-O-beta-D-glucopyranosyloxy]flavone (1) by 1D and 2D NMR techniques and mass spectra, was isolated along with kaempferol-3-O-rutinoside (2), kaempferol-3-O-glucoside (3), rutin (4), quercetin-3-O-glucoside (5), isorhamnetin-3-O-rutinoside (6), and isorhamnetin-3-O-glucoside (7). The antioxidant and radical scavenging activities of these compounds and the whole crude methanol extract were evaluated. The organic extract can inhibit MDA marker's synthesis by 57%. All the metabolites displayed good reducing power, with the kaempferol (2,3) and isorhamnetin derivatives (6,7) being less active than the corresponding quercetin derivatives 4,5. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/17846577/Reactive_oxygen_species_scavenging_activity_of_flavone_glycosides_from_Melilotus_neapolitana_ L2 - https://www.mdpi.com/resolver?pii=12020263 DB - PRIME DP - Unbound Medicine ER -