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Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5.
J Pharm Sci. 2008 Jun; 97(6):2110-20.JP

Abstract

In order to reduce the crystallinity of PEG 6000, blends were prepared by spray drying and extrusion with the following polymers; PVP K25, PVPVA 64, and HPMC 2910 E5. The maximal reduction of crystallinity in PEG 6000 was obtained by co-spray drying with HPMC 2910 E5. In the next step the model drug Itraconazole was added to the blend and the resulting ternary solid dispersions were characterized. The results of this study show that the addition of PEG 6000 to the Itraconazole/HPMC 2910 E5 system leads to phase separation that in most cases gives rise to recrystallization of either PEG 6000 or Itraconazole. For all ternary dispersions containing 20% of Itraconazole the drug was highly amorphous and the dissolution was improved compared to the binary 20/80 w/w Itraconazole/HPMC 2910 E5 solid dispersion. For all ternary dispersions containing 40% of Itraconazole, the drug was partially crystalline and the dissolution was lower than the dissolution of the binary 40/60 w/w Itraconazole/HPMC 2910 E5 dispersion. These results show that provided Itraconazole is highly amorphous the addition of PEG 6000 to HPMC 2910 E5 leads to an increase in drug release.

Authors+Show Affiliations

Laboratorium voor Farmacotechnologie en Biofarmacie, K.U.Leuven, Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17847067

Citation

Janssens, Sandrien, et al. "Characterization of Ternary Solid Dispersions of Itraconazole, PEG 6000, and HPMC 2910 E5." Journal of Pharmaceutical Sciences, vol. 97, no. 6, 2008, pp. 2110-20.
Janssens S, de Armas HN, Roberts CJ, et al. Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5. J Pharm Sci. 2008;97(6):2110-20.
Janssens, S., de Armas, H. N., Roberts, C. J., & Van den Mooter, G. (2008). Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5. Journal of Pharmaceutical Sciences, 97(6), 2110-20.
Janssens S, et al. Characterization of Ternary Solid Dispersions of Itraconazole, PEG 6000, and HPMC 2910 E5. J Pharm Sci. 2008;97(6):2110-20. PubMed PMID: 17847067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of ternary solid dispersions of itraconazole, PEG 6000, and HPMC 2910 E5. AU - Janssens,Sandrien, AU - de Armas,Hector Novoa, AU - Roberts,Clive J, AU - Van den Mooter,Guy, PY - 2007/9/12/pubmed PY - 2008/8/16/medline PY - 2007/9/12/entrez SP - 2110 EP - 20 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 97 IS - 6 N2 - In order to reduce the crystallinity of PEG 6000, blends were prepared by spray drying and extrusion with the following polymers; PVP K25, PVPVA 64, and HPMC 2910 E5. The maximal reduction of crystallinity in PEG 6000 was obtained by co-spray drying with HPMC 2910 E5. In the next step the model drug Itraconazole was added to the blend and the resulting ternary solid dispersions were characterized. The results of this study show that the addition of PEG 6000 to the Itraconazole/HPMC 2910 E5 system leads to phase separation that in most cases gives rise to recrystallization of either PEG 6000 or Itraconazole. For all ternary dispersions containing 20% of Itraconazole the drug was highly amorphous and the dissolution was improved compared to the binary 20/80 w/w Itraconazole/HPMC 2910 E5 solid dispersion. For all ternary dispersions containing 40% of Itraconazole, the drug was partially crystalline and the dissolution was lower than the dissolution of the binary 40/60 w/w Itraconazole/HPMC 2910 E5 dispersion. These results show that provided Itraconazole is highly amorphous the addition of PEG 6000 to HPMC 2910 E5 leads to an increase in drug release. SN - 0022-3549 UR - https://www.unboundmedicine.com/medline/citation/17847067/Characterization_of_ternary_solid_dispersions_of_itraconazole_PEG_6000_and_HPMC_2910_E5_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(16)32571-0 DB - PRIME DP - Unbound Medicine ER -