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Bats, civets and the emergence of SARS.
Curr Top Microbiol Immunol. 2007; 315:325-44.CT

Abstract

Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets (Paguma larvata), together with two other wildlife animals, sampled from a live animal market were infected with SARS-CoV or a closely related virus. Recently, horseshoe bats in the genus Rhinolophus have been identified as natural reservoir of SARS-like coronaviruses. Here, we review studies by different groups demonstrating that SARS-CoV succeeded in spillover from a wildlife reservoir (probably bats) to human population via an intermediate host(s) and that rapid virus evolution played a key role in the adaptation of SARS-CoVs in at least two nonreservoir species within a short period.

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Authors+Show Affiliations

Wang LF
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, 3220 Australia. Linfa.Wang@csiro.au
Eaton BT
No affiliation info available

MeSH

Adaptation, PhysiologicalAnimalsAnimals, WildChiropteraDisease OutbreaksDisease ReservoirsHumansSARS VirusSevere Acute Respiratory SyndromeSpecies SpecificityViverridaeZoonoses

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

17848070

Citation

Wang, L F., and B T. Eaton. "Bats, Civets and the Emergence of SARS." Current Topics in Microbiology and Immunology, vol. 315, 2007, pp. 325-44.
Wang LF, Eaton BT. Bats, civets and the emergence of SARS. Curr Top Microbiol Immunol. 2007;315:325-44.
Wang, L. F., & Eaton, B. T. (2007). Bats, civets and the emergence of SARS. Current Topics in Microbiology and Immunology, 315, 325-44.
Wang LF, Eaton BT. Bats, Civets and the Emergence of SARS. Curr Top Microbiol Immunol. 2007;315:325-44. PubMed PMID: 17848070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bats, civets and the emergence of SARS. AU - Wang,L F, AU - Eaton,B T, PY - 2007/9/13/pubmed PY - 2007/9/28/medline PY - 2007/9/13/entrez SP - 325 EP - 44 JF - Current topics in microbiology and immunology JO - Curr Top Microbiol Immunol VL - 315 N2 - Severe acute respiratory syndrome (SARS) was the first pandemic transmissible disease of previously unknown aetiology in the twenty-first century. Early epidemiologic investigations suggested an animal origin for SARS-CoV. Virological and serological studies indicated that masked palm civets (Paguma larvata), together with two other wildlife animals, sampled from a live animal market were infected with SARS-CoV or a closely related virus. Recently, horseshoe bats in the genus Rhinolophus have been identified as natural reservoir of SARS-like coronaviruses. Here, we review studies by different groups demonstrating that SARS-CoV succeeded in spillover from a wildlife reservoir (probably bats) to human population via an intermediate host(s) and that rapid virus evolution played a key role in the adaptation of SARS-CoVs in at least two nonreservoir species within a short period. SN - 0070-217X UR - https://www.unboundmedicine.com/medline/citation/17848070/Bats_civets_and_the_emergence_of_SARS_ L2 - https://doi.org/10.1007/978-3-540-70962-6_13 DB - PRIME DP - Unbound Medicine ER -