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The maximum tumour length in biopsy cores as a predictor of outcome after radical prostatectomy.
BJU Int. 2008 Jan; 101(2):175-80.BI

Abstract

OBJECTIVES

To evaluate maximum tumour length (MTL) in biopsy cores as a predictor of prostate-specific antigen (PSA)-failure, systemic failure, and death from prostate cancer after radical prostatectomy (RP).

PATIENTS AND METHODS

We assessed 209 men with clinically localized prostate cancer treated with RP; preoperative variables were correlated with unfavourable pathological characteristics in the RP specimens and with outcome after surgery, using univariate and multivariate analysis.

RESULTS

The median (range) MTL was 4 (0.2-19) mm and correlated with adverse pathological findings, including specimen Gleason score (P = 0.003), pT3 (P < 0.001), seminal vesicle invasion (P < 0.001) and lymph node involvement (P = 0.019) in multivariate analysis. Preoperative PSA (P < 0.001), biopsy Gleason score (P = 0.002), and MTL (P = 0.045) were independent predictors of PSA failure, whereas only MTL remained a predictor of systemic-failure (P < 0.001) and death from prostate cancer (P = 0.004). The median (range) follow-up after surgery was 90 (17-152) months, during which 83 patients had PSA failure, 20 developed systemic failure and 15 died from prostate cancer.

CONCLUSIONS

The MTL correlates well with adverse pathological findings and appears to be an independent predictor of outcome after RP. Patients with a greater MTL might have cancer with an aggressive phenotype and therefore be candidates for more aggressive therapies.

Authors+Show Affiliations

Department of Urology, Jikei University School of Medicine, Minato-ku, Tokyo, Japan. norihiro@jikei.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17850362

Citation

Hayashi, Norihiro, et al. "The Maximum Tumour Length in Biopsy Cores as a Predictor of Outcome After Radical Prostatectomy." BJU International, vol. 101, no. 2, 2008, pp. 175-80.
Hayashi N, Urashima M, Kuruma H, et al. The maximum tumour length in biopsy cores as a predictor of outcome after radical prostatectomy. BJU Int. 2008;101(2):175-80.
Hayashi, N., Urashima, M., Kuruma, H., Arai, Y., Kuwao, S., Iwamura, M., & Egawa, S. (2008). The maximum tumour length in biopsy cores as a predictor of outcome after radical prostatectomy. BJU International, 101(2), 175-80.
Hayashi N, et al. The Maximum Tumour Length in Biopsy Cores as a Predictor of Outcome After Radical Prostatectomy. BJU Int. 2008;101(2):175-80. PubMed PMID: 17850362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The maximum tumour length in biopsy cores as a predictor of outcome after radical prostatectomy. AU - Hayashi,Norihiro, AU - Urashima,Mitsuyoshi, AU - Kuruma,Hidetoshi, AU - Arai,Yoichi, AU - Kuwao,Sadahito, AU - Iwamura,Masatsugu, AU - Egawa,Shin, Y1 - 2007/09/10/ PY - 2007/9/14/pubmed PY - 2008/1/25/medline PY - 2007/9/14/entrez SP - 175 EP - 80 JF - BJU international JO - BJU Int VL - 101 IS - 2 N2 - OBJECTIVES: To evaluate maximum tumour length (MTL) in biopsy cores as a predictor of prostate-specific antigen (PSA)-failure, systemic failure, and death from prostate cancer after radical prostatectomy (RP). PATIENTS AND METHODS: We assessed 209 men with clinically localized prostate cancer treated with RP; preoperative variables were correlated with unfavourable pathological characteristics in the RP specimens and with outcome after surgery, using univariate and multivariate analysis. RESULTS: The median (range) MTL was 4 (0.2-19) mm and correlated with adverse pathological findings, including specimen Gleason score (P = 0.003), pT3 (P < 0.001), seminal vesicle invasion (P < 0.001) and lymph node involvement (P = 0.019) in multivariate analysis. Preoperative PSA (P < 0.001), biopsy Gleason score (P = 0.002), and MTL (P = 0.045) were independent predictors of PSA failure, whereas only MTL remained a predictor of systemic-failure (P < 0.001) and death from prostate cancer (P = 0.004). The median (range) follow-up after surgery was 90 (17-152) months, during which 83 patients had PSA failure, 20 developed systemic failure and 15 died from prostate cancer. CONCLUSIONS: The MTL correlates well with adverse pathological findings and appears to be an independent predictor of outcome after RP. Patients with a greater MTL might have cancer with an aggressive phenotype and therefore be candidates for more aggressive therapies. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/17850362/The_maximum_tumour_length_in_biopsy_cores_as_a_predictor_of_outcome_after_radical_prostatectomy_ DB - PRIME DP - Unbound Medicine ER -