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Cortical spreading depression and estrogen.
Headache 2007; 47 Suppl 2:S79-85H

Abstract

Cortical spreading depression (CSD) is an electrophysiological phenomenon characterized by a wave of excitation followed by inhibition. The aura phase that precedes migraine headache in about 20-30% of migraineurs shares overlapping characteristics with CSD. Studies of rare autosomal-dominant forms of migraine with aura provide strong evidence that the threshold for evoking CSD and aura are related to neuronal excitability. Although the relationship between CSD and migraine without aura is not completely understood, the molecular abnormalities that predispose to migraine with aura illustrate the importance of physiologic events associated with neuronal hyperexcitability, and provide a basis for understanding a more generalized view of migraine.

Authors+Show Affiliations

Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17850538

Citation

Eikermann-Haerter, Katharina, et al. "Cortical Spreading Depression and Estrogen." Headache, vol. 47 Suppl 2, 2007, pp. S79-85.
Eikermann-Haerter K, Kudo C, Moskowitz MA. Cortical spreading depression and estrogen. Headache. 2007;47 Suppl 2:S79-85.
Eikermann-Haerter, K., Kudo, C., & Moskowitz, M. A. (2007). Cortical spreading depression and estrogen. Headache, 47 Suppl 2, pp. S79-85.
Eikermann-Haerter K, Kudo C, Moskowitz MA. Cortical Spreading Depression and Estrogen. Headache. 2007;47 Suppl 2:S79-85. PubMed PMID: 17850538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortical spreading depression and estrogen. AU - Eikermann-Haerter,Katharina, AU - Kudo,Chiho, AU - Moskowitz,Michael A, PY - 2007/10/25/pubmed PY - 2007/12/6/medline PY - 2007/10/25/entrez SP - S79 EP - 85 JF - Headache JO - Headache VL - 47 Suppl 2 N2 - Cortical spreading depression (CSD) is an electrophysiological phenomenon characterized by a wave of excitation followed by inhibition. The aura phase that precedes migraine headache in about 20-30% of migraineurs shares overlapping characteristics with CSD. Studies of rare autosomal-dominant forms of migraine with aura provide strong evidence that the threshold for evoking CSD and aura are related to neuronal excitability. Although the relationship between CSD and migraine without aura is not completely understood, the molecular abnormalities that predispose to migraine with aura illustrate the importance of physiologic events associated with neuronal hyperexcitability, and provide a basis for understanding a more generalized view of migraine. SN - 0017-8748 UR - https://www.unboundmedicine.com/medline/citation/17850538/Cortical_spreading_depression_and_estrogen_ L2 - https://doi.org/10.1111/j.1526-4610.2007.00818.x DB - PRIME DP - Unbound Medicine ER -