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Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) graft copolymers.
Colloids Surf B Biointerfaces 2008; 61(2):164-9CS

Abstract

Biodegradable amphiphilic graft copolymers with different compositions were synthesized by grafting poly(L-lactide) (PLLA) sequences onto a water-soluble poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) backbone. The critical micelle concentration (CMC) of the graft polymers was determined by fluorescence probe technique. Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the graft polymers were proved to have low cytotoxicity. Based on the specific physicochemical property of the graft copolymers, submicron sized microsphere drug delivery systems were prepared by a very convenient "ultrasonic dispersion method", which did not involve toxic organic solvents. The drug-loaded microspheres had a regular spherical shape with a narrow size distribution. A hydrophobic drug, prednisone acetate, was encapsulated into polymeric microspheres and the in vitro drug release was studied.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17851053

Citation

Zhou, Yu-Xiang, et al. "Fabrication and in Vitro Drug Release Study of Microsphere Drug Delivery Systems Based On Amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) Graft Copolymers." Colloids and Surfaces. B, Biointerfaces, vol. 61, no. 2, 2008, pp. 164-9.
Zhou YX, Li SL, Fu HL, et al. Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) graft copolymers. Colloids Surf B Biointerfaces. 2008;61(2):164-9.
Zhou, Y. X., Li, S. L., Fu, H. L., Cheng, S. X., Zhang, X. Z., & Zhuo, R. X. (2008). Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) graft copolymers. Colloids and Surfaces. B, Biointerfaces, 61(2), pp. 164-9.
Zhou YX, et al. Fabrication and in Vitro Drug Release Study of Microsphere Drug Delivery Systems Based On Amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) Graft Copolymers. Colloids Surf B Biointerfaces. 2008 Feb 15;61(2):164-9. PubMed PMID: 17851053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(L-lactide) graft copolymers. AU - Zhou,Yu-Xiang, AU - Li,Song-Lin, AU - Fu,Hui-Li, AU - Cheng,Si-Xue, AU - Zhang,Xian-Zheng, AU - Zhuo,Ren-Xi, Y1 - 2007/08/06/ PY - 2007/05/13/received PY - 2007/07/30/revised PY - 2007/08/01/accepted PY - 2007/9/14/pubmed PY - 2008/4/11/medline PY - 2007/9/14/entrez SP - 164 EP - 9 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 61 IS - 2 N2 - Biodegradable amphiphilic graft copolymers with different compositions were synthesized by grafting poly(L-lactide) (PLLA) sequences onto a water-soluble poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) backbone. The critical micelle concentration (CMC) of the graft polymers was determined by fluorescence probe technique. Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the graft polymers were proved to have low cytotoxicity. Based on the specific physicochemical property of the graft copolymers, submicron sized microsphere drug delivery systems were prepared by a very convenient "ultrasonic dispersion method", which did not involve toxic organic solvents. The drug-loaded microspheres had a regular spherical shape with a narrow size distribution. A hydrophobic drug, prednisone acetate, was encapsulated into polymeric microspheres and the in vitro drug release was studied. SN - 0927-7765 UR - https://www.unboundmedicine.com/medline/citation/17851053/Fabrication_and_in_vitro_drug_release_study_of_microsphere_drug_delivery_systems_based_on_amphiphilic_poly_alphabeta_[N__2_hydroxyethyl__L_aspartamide]_g_poly_L_lactide__graft_copolymers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(07)00309-8 DB - PRIME DP - Unbound Medicine ER -