Tags

Type your tag names separated by a space and hit enter

Anti-endothelial cell antibodies in patients with interstitial lung diseases.
Respir Med. 2008 Jan; 102(1):128-33.RM

Abstract

BACKGROUND

Anti-endothelial cell antibodies (AECA) are circulating antibodies that bind to endothelial antigens and induce endothelial cell damage. AECA have been detected in patients with collagen vascular disease (CVD) and their presence is associated with interstitial lung disease (ILD) in cases of CVD. However, the prevalence of AECA in patients with idiopathic interstitial pneumonias (IIPs) is not known.

METHODS

We investigated the prevalence of AECA in patients with IIPs. We also examined whether the expression of AECA differed among the histologic subgroups usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), and compared the values with those of CVD-associated ILD (CVD-ILD). Twenty patients with IIPs and 24 patients with CVD-ILD were studied. Serum samples were examined for AECA by cellular enzyme-linked immunosorbent assay (ELISA) using human umbilical vein endothelial cells. Values are expressed as ELISA ratios (ER).

RESULTS

All sera from patients with idiopathic pulmonary fibrosis (IPF)/UIP were negative for AECA, whereas 5 out of 10 with idiopathic NSIP, 5 out of 14 with CVD-UIP and 4 out of 10 with CVD-NSIP tested positive (p<0.05). ER values were significantly lower in patients with IPF/UIP than idiopathic NSIP, CVD-UIP or CVD-NSIP (p<0.05). Among idiopathic NSIP, CVD-NSIP and CVD-UIP patients, the ER values did not differ.

CONCLUSIONS

Among IIP patients, only those with idiopathic NSIP, not IPF/UIP, tested positive for AECA. The prevalence of AECA in idiopathic NSIP patients was similar to that in CVD-ILD patients. These results may provide important information to understand the distinct pathophysiology of each form of IIPs.

Authors+Show Affiliations

The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17851060

Citation

Matsui, Takashi, et al. "Anti-endothelial Cell Antibodies in Patients With Interstitial Lung Diseases." Respiratory Medicine, vol. 102, no. 1, 2008, pp. 128-33.
Matsui T, Inui N, Suda T, et al. Anti-endothelial cell antibodies in patients with interstitial lung diseases. Respir Med. 2008;102(1):128-33.
Matsui, T., Inui, N., Suda, T., & Chida, K. (2008). Anti-endothelial cell antibodies in patients with interstitial lung diseases. Respiratory Medicine, 102(1), 128-33.
Matsui T, et al. Anti-endothelial Cell Antibodies in Patients With Interstitial Lung Diseases. Respir Med. 2008;102(1):128-33. PubMed PMID: 17851060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-endothelial cell antibodies in patients with interstitial lung diseases. AU - Matsui,Takashi, AU - Inui,Naoki, AU - Suda,Takafumi, AU - Chida,Kingo, Y1 - 2007/09/11/ PY - 2007/05/04/received PY - 2007/06/28/revised PY - 2007/07/24/accepted PY - 2007/9/14/pubmed PY - 2008/8/15/medline PY - 2007/9/14/entrez SP - 128 EP - 33 JF - Respiratory medicine JO - Respir Med VL - 102 IS - 1 N2 - BACKGROUND: Anti-endothelial cell antibodies (AECA) are circulating antibodies that bind to endothelial antigens and induce endothelial cell damage. AECA have been detected in patients with collagen vascular disease (CVD) and their presence is associated with interstitial lung disease (ILD) in cases of CVD. However, the prevalence of AECA in patients with idiopathic interstitial pneumonias (IIPs) is not known. METHODS: We investigated the prevalence of AECA in patients with IIPs. We also examined whether the expression of AECA differed among the histologic subgroups usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), and compared the values with those of CVD-associated ILD (CVD-ILD). Twenty patients with IIPs and 24 patients with CVD-ILD were studied. Serum samples were examined for AECA by cellular enzyme-linked immunosorbent assay (ELISA) using human umbilical vein endothelial cells. Values are expressed as ELISA ratios (ER). RESULTS: All sera from patients with idiopathic pulmonary fibrosis (IPF)/UIP were negative for AECA, whereas 5 out of 10 with idiopathic NSIP, 5 out of 14 with CVD-UIP and 4 out of 10 with CVD-NSIP tested positive (p<0.05). ER values were significantly lower in patients with IPF/UIP than idiopathic NSIP, CVD-UIP or CVD-NSIP (p<0.05). Among idiopathic NSIP, CVD-NSIP and CVD-UIP patients, the ER values did not differ. CONCLUSIONS: Among IIP patients, only those with idiopathic NSIP, not IPF/UIP, tested positive for AECA. The prevalence of AECA in idiopathic NSIP patients was similar to that in CVD-ILD patients. These results may provide important information to understand the distinct pathophysiology of each form of IIPs. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/17851060/Anti_endothelial_cell_antibodies_in_patients_with_interstitial_lung_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(07)00330-7 DB - PRIME DP - Unbound Medicine ER -