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The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation.
Mol Cell Neurosci. 2007 Nov; 36(3):381-91.MC

Abstract

TNFalpha is involved in the generation of hyperalgesia in pathological states such as neuropathy and inflammation. The pronociceptive action of TNFalpha may be mediated at least in part by activation of the TRPV1 receptor which transduces heat stimuli in primary nociceptive afferents and mediates thermal hyperalgesia. In the present study, we investigated in cultured dorsal root ganglion (DRG) neurones, the somata of primary afferent fibres, whether TNFalpha increases TRPV1 receptor expression. We found that long-term exposure of DRG neurones of both rat and mouse to TNFalpha significantly increased the proportion of DRG neurones expressing TRPV1 receptor-like immunoreactivity. This TNFalpha effect was abolished in mice DRG neurones when DRG cultures were obtained from tnfr1/2-/- and tnfr1-/-, but not from tnfr2-/- mice. Furthermore, we found that activation of ERK but not of p38 kinase or cyclooxygenases is critically involved in the TNFalpha-induced increase of TRPV1 receptor expression.

Authors+Show Affiliations

Institute of Physiology I, Friedrich Schiller University of Jena, Teichgraben 8, D-07740 Jena, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17851089

Citation

Hensellek, Susanne, et al. "The Cytokine TNFalpha Increases the Proportion of DRG Neurones Expressing the TRPV1 Receptor Via the TNFR1 Receptor and ERK Activation." Molecular and Cellular Neurosciences, vol. 36, no. 3, 2007, pp. 381-91.
Hensellek S, Brell P, Schaible HG, et al. The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci. 2007;36(3):381-91.
Hensellek, S., Brell, P., Schaible, H. G., Bräuer, R., & Segond von Banchet, G. (2007). The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Molecular and Cellular Neurosciences, 36(3), 381-91.
Hensellek S, et al. The Cytokine TNFalpha Increases the Proportion of DRG Neurones Expressing the TRPV1 Receptor Via the TNFR1 Receptor and ERK Activation. Mol Cell Neurosci. 2007;36(3):381-91. PubMed PMID: 17851089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. AU - Hensellek,Susanne, AU - Brell,Patrice, AU - Schaible,Hans-Georg, AU - Bräuer,Rolf, AU - Segond von Banchet,Gisela, Y1 - 2007/08/01/ PY - 2007/03/29/received PY - 2007/07/16/revised PY - 2007/07/24/accepted PY - 2007/9/14/pubmed PY - 2008/1/23/medline PY - 2007/9/14/entrez SP - 381 EP - 91 JF - Molecular and cellular neurosciences JO - Mol Cell Neurosci VL - 36 IS - 3 N2 - TNFalpha is involved in the generation of hyperalgesia in pathological states such as neuropathy and inflammation. The pronociceptive action of TNFalpha may be mediated at least in part by activation of the TRPV1 receptor which transduces heat stimuli in primary nociceptive afferents and mediates thermal hyperalgesia. In the present study, we investigated in cultured dorsal root ganglion (DRG) neurones, the somata of primary afferent fibres, whether TNFalpha increases TRPV1 receptor expression. We found that long-term exposure of DRG neurones of both rat and mouse to TNFalpha significantly increased the proportion of DRG neurones expressing TRPV1 receptor-like immunoreactivity. This TNFalpha effect was abolished in mice DRG neurones when DRG cultures were obtained from tnfr1/2-/- and tnfr1-/-, but not from tnfr2-/- mice. Furthermore, we found that activation of ERK but not of p38 kinase or cyclooxygenases is critically involved in the TNFalpha-induced increase of TRPV1 receptor expression. SN - 1044-7431 UR - https://www.unboundmedicine.com/medline/citation/17851089/The_cytokine_TNFalpha_increases_the_proportion_of_DRG_neurones_expressing_the_TRPV1_receptor_via_the_TNFR1_receptor_and_ERK_activation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-7431(07)00172-8 DB - PRIME DP - Unbound Medicine ER -