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Brain reserve hypothesis in dementia.
J Alzheimers Dis 2007; 12(1):11-22JA

Abstract

The concept of brain reserve refers to the ability to tolerate the age-related changes and the disease related pathology in the brain without developing clear clinical symptoms or signs. A considerable body of biological research has documented that a number of factors including education, work complexity, social network, and leisure activities may contribute to this reserve allowing cognitive function to be maintained in old ages. Epidemiological studies have also related these factors to the development of dementia, suggesting that intellectual challenges experienced across the whole life span may increase the brain reserve and be crucial for the occurrence of dementia symptoms in late life. This paper is a systematic review of the published epidemiological studies on this topic. The availability of numerous epidemiological and biological data investigating the reserve hypothesis in dementia permits some preliminary conclusions. High education, adult-life occupational work complexity, as well as a mentally and socially integrated lifestyle in late life could postpone the onset of clinical dementia and AD. The relevance of physical activity itself remains in debate, as most physical activities include also social and mental stimulation. Leisure activities with all three components--physical, mental and social--seem to have the most beneficial effect. Delaying dementia onset by five years would halve dementia prevalence and substantially decrease the number of dementia cases in the community.

Authors+Show Affiliations

Aging Research Center, Department NVS, Karolinska Institute, and Stockholm Gerontology Research Center, Stockholm, Sweden. laura.fratiglioni@ki.seNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

17851191

Citation

Fratiglioni, Laura, and Hui-Xin Wang. "Brain Reserve Hypothesis in Dementia." Journal of Alzheimer's Disease : JAD, vol. 12, no. 1, 2007, pp. 11-22.
Fratiglioni L, Wang HX. Brain reserve hypothesis in dementia. J Alzheimers Dis. 2007;12(1):11-22.
Fratiglioni, L., & Wang, H. X. (2007). Brain reserve hypothesis in dementia. Journal of Alzheimer's Disease : JAD, 12(1), pp. 11-22.
Fratiglioni L, Wang HX. Brain Reserve Hypothesis in Dementia. J Alzheimers Dis. 2007;12(1):11-22. PubMed PMID: 17851191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain reserve hypothesis in dementia. AU - Fratiglioni,Laura, AU - Wang,Hui-Xin, PY - 2007/9/14/pubmed PY - 2007/12/18/medline PY - 2007/9/14/entrez SP - 11 EP - 22 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 12 IS - 1 N2 - The concept of brain reserve refers to the ability to tolerate the age-related changes and the disease related pathology in the brain without developing clear clinical symptoms or signs. A considerable body of biological research has documented that a number of factors including education, work complexity, social network, and leisure activities may contribute to this reserve allowing cognitive function to be maintained in old ages. Epidemiological studies have also related these factors to the development of dementia, suggesting that intellectual challenges experienced across the whole life span may increase the brain reserve and be crucial for the occurrence of dementia symptoms in late life. This paper is a systematic review of the published epidemiological studies on this topic. The availability of numerous epidemiological and biological data investigating the reserve hypothesis in dementia permits some preliminary conclusions. High education, adult-life occupational work complexity, as well as a mentally and socially integrated lifestyle in late life could postpone the onset of clinical dementia and AD. The relevance of physical activity itself remains in debate, as most physical activities include also social and mental stimulation. Leisure activities with all three components--physical, mental and social--seem to have the most beneficial effect. Delaying dementia onset by five years would halve dementia prevalence and substantially decrease the number of dementia cases in the community. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/17851191/Brain_reserve_hypothesis_in_dementia_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=12&issue=1&spage=11 DB - PRIME DP - Unbound Medicine ER -