Tags

Type your tag names separated by a space and hit enter

Brain reserve hypothesis in dementia.

Abstract

The concept of brain reserve refers to the ability to tolerate the age-related changes and the disease related pathology in the brain without developing clear clinical symptoms or signs. A considerable body of biological research has documented that a number of factors including education, work complexity, social network, and leisure activities may contribute to this reserve allowing cognitive function to be maintained in old ages. Epidemiological studies have also related these factors to the development of dementia, suggesting that intellectual challenges experienced across the whole life span may increase the brain reserve and be crucial for the occurrence of dementia symptoms in late life. This paper is a systematic review of the published epidemiological studies on this topic. The availability of numerous epidemiological and biological data investigating the reserve hypothesis in dementia permits some preliminary conclusions. High education, adult-life occupational work complexity, as well as a mentally and socially integrated lifestyle in late life could postpone the onset of clinical dementia and AD. The relevance of physical activity itself remains in debate, as most physical activities include also social and mental stimulation. Leisure activities with all three components--physical, mental and social--seem to have the most beneficial effect. Delaying dementia onset by five years would halve dementia prevalence and substantially decrease the number of dementia cases in the community.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Aging Research Center, Department NVS, Karolinska Institute, and Stockholm Gerontology Research Center, Stockholm, Sweden. laura.fratiglioni@ki.se

    Source

    MeSH

    Aged
    Brain
    Dementia
    Disease Progression
    Educational Status
    Humans
    Job Satisfaction
    Leisure Activities
    Neuropsychological Tests
    Social Support
    Workplace

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    17851191

    Citation

    Fratiglioni, Laura, and Hui-Xin Wang. "Brain Reserve Hypothesis in Dementia." Journal of Alzheimer's Disease : JAD, vol. 12, no. 1, 2007, pp. 11-22.
    Fratiglioni L, Wang HX. Brain reserve hypothesis in dementia. J Alzheimers Dis. 2007;12(1):11-22.
    Fratiglioni, L., & Wang, H. X. (2007). Brain reserve hypothesis in dementia. Journal of Alzheimer's Disease : JAD, 12(1), pp. 11-22.
    Fratiglioni L, Wang HX. Brain Reserve Hypothesis in Dementia. J Alzheimers Dis. 2007;12(1):11-22. PubMed PMID: 17851191.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Brain reserve hypothesis in dementia. AU - Fratiglioni,Laura, AU - Wang,Hui-Xin, PY - 2007/9/14/pubmed PY - 2007/12/18/medline PY - 2007/9/14/entrez SP - 11 EP - 22 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 12 IS - 1 N2 - The concept of brain reserve refers to the ability to tolerate the age-related changes and the disease related pathology in the brain without developing clear clinical symptoms or signs. A considerable body of biological research has documented that a number of factors including education, work complexity, social network, and leisure activities may contribute to this reserve allowing cognitive function to be maintained in old ages. Epidemiological studies have also related these factors to the development of dementia, suggesting that intellectual challenges experienced across the whole life span may increase the brain reserve and be crucial for the occurrence of dementia symptoms in late life. This paper is a systematic review of the published epidemiological studies on this topic. The availability of numerous epidemiological and biological data investigating the reserve hypothesis in dementia permits some preliminary conclusions. High education, adult-life occupational work complexity, as well as a mentally and socially integrated lifestyle in late life could postpone the onset of clinical dementia and AD. The relevance of physical activity itself remains in debate, as most physical activities include also social and mental stimulation. Leisure activities with all three components--physical, mental and social--seem to have the most beneficial effect. Delaying dementia onset by five years would halve dementia prevalence and substantially decrease the number of dementia cases in the community. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/17851191/Brain_reserve_hypothesis_in_dementia_ L2 - https://content.iospress.com/openurl?genre=article&issn=1387-2877&volume=12&issue=1&spage=11 DB - PRIME DP - Unbound Medicine ER -