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Carotid intima-media thickness and cognitive function in elderly women: a population-based study.
Neuroepidemiology. 2007; 28(4):207-13.N

Abstract

OBJECTIVE

Several vascular risk factors have been linked to cognitive decline. However, little is known about the association between the atherosclerotic process and cognitive impairment. We investigated whether carotid intima-media thickness (IMT) predicts the risk of cognitive impairment and whether the putative impairment is specific for some cognitive domains.

METHODS

A 12-year population-based follow-up study was performed for a total of 91 women, aged 60-70 years at baseline. Ultrasonographically assessed carotid artery IMT and the Mini-Mental State Examination test were performed at baseline and 12-year follow-up. A detailed cognitive evaluation for memory and cognitive speed was performed in 2003. The mean of left and right carotid bifurcation IMT was used in the analyses for association with the risk for poor cognitive speed and memory.

RESULTS

Increased IMT at baseline was an independent predictor for poor memory (beta = -5.004, 95% confidence interval = -7.74 to -2.27; p = 0.001) and cognitive speed (beta = 2.562, 95% confidence interval = 1.19-4.94; p = 0.035) at 12-year follow-up after adjustment for age, education, depression, plasma LDL cholesterol, systolic blood pressure, cardiovascular disease, hormone replacement therapy, smoking, alcohol consumption and physical activity. The risk for poor memory (p = 0.023 for linear trend) and cognitive speed (p = 0.070 for linear trend) increased with increasing IMT tertiles.

CONCLUSIONS

Carotid IMT predicts an increased risk for cognitive impairment, particularly poor memory and cognitive speed, in elderly women.

Authors+Show Affiliations

Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. pirjo.komulainen@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17851259

Citation

Komulainen, Pirjo, et al. "Carotid Intima-media Thickness and Cognitive Function in Elderly Women: a Population-based Study." Neuroepidemiology, vol. 28, no. 4, 2007, pp. 207-13.
Komulainen P, Kivipelto M, Lakka TA, et al. Carotid intima-media thickness and cognitive function in elderly women: a population-based study. Neuroepidemiology. 2007;28(4):207-13.
Komulainen, P., Kivipelto, M., Lakka, T. A., Hassinen, M., Helkala, E. L., Patja, K., Nissinen, A., & Rauramaa, R. (2007). Carotid intima-media thickness and cognitive function in elderly women: a population-based study. Neuroepidemiology, 28(4), 207-13.
Komulainen P, et al. Carotid Intima-media Thickness and Cognitive Function in Elderly Women: a Population-based Study. Neuroepidemiology. 2007;28(4):207-13. PubMed PMID: 17851259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid intima-media thickness and cognitive function in elderly women: a population-based study. AU - Komulainen,Pirjo, AU - Kivipelto,Miia, AU - Lakka,Timo A, AU - Hassinen,Maija, AU - Helkala,Eeva-Liisa, AU - Patja,Kristiina, AU - Nissinen,Aulikki, AU - Rauramaa,Rainer, Y1 - 2007/09/11/ PY - 2007/9/14/pubmed PY - 2007/12/6/medline PY - 2007/9/14/entrez SP - 207 EP - 13 JF - Neuroepidemiology JO - Neuroepidemiology VL - 28 IS - 4 N2 - OBJECTIVE: Several vascular risk factors have been linked to cognitive decline. However, little is known about the association between the atherosclerotic process and cognitive impairment. We investigated whether carotid intima-media thickness (IMT) predicts the risk of cognitive impairment and whether the putative impairment is specific for some cognitive domains. METHODS: A 12-year population-based follow-up study was performed for a total of 91 women, aged 60-70 years at baseline. Ultrasonographically assessed carotid artery IMT and the Mini-Mental State Examination test were performed at baseline and 12-year follow-up. A detailed cognitive evaluation for memory and cognitive speed was performed in 2003. The mean of left and right carotid bifurcation IMT was used in the analyses for association with the risk for poor cognitive speed and memory. RESULTS: Increased IMT at baseline was an independent predictor for poor memory (beta = -5.004, 95% confidence interval = -7.74 to -2.27; p = 0.001) and cognitive speed (beta = 2.562, 95% confidence interval = 1.19-4.94; p = 0.035) at 12-year follow-up after adjustment for age, education, depression, plasma LDL cholesterol, systolic blood pressure, cardiovascular disease, hormone replacement therapy, smoking, alcohol consumption and physical activity. The risk for poor memory (p = 0.023 for linear trend) and cognitive speed (p = 0.070 for linear trend) increased with increasing IMT tertiles. CONCLUSIONS: Carotid IMT predicts an increased risk for cognitive impairment, particularly poor memory and cognitive speed, in elderly women. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/17851259/Carotid_intima_media_thickness_and_cognitive_function_in_elderly_women:_a_population_based_study_ L2 - https://www.karger.com?DOI=10.1159/000108112 DB - PRIME DP - Unbound Medicine ER -