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Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study.
Climacteric. 2007 Oct; 10(5):427-37.C

Abstract

OBJECTIVES

Significant differences in the prevalence of menopausal symptoms and in lipid profiles have previously been reported for nine ethnic groups of postmenopausal Asian women participating in the Pan-Asia Menopause (PAM) study. Based on these findings, we tested the hypothesis that reproductive hormone profiles differ among the nine ethnic groups under investigation in the PAM study.

METHODS

Baseline serum samples from postmenopausal women (n=1020) representing nine ethnic groups were analyzed at a central laboratory by electro-chemiluminescence immunoassay methods. Hormone concentrations were measured for estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH).

RESULTS

The hormone levels for the overall study population (mean+/-SD) were: E2=74.1+/-125.1 pmol/l (n=1015); FSH=81.2+/-31.4 IU/l (n=1013); LH=36.8+/-15.6 IU/l (n=1015). Estradiol levels ranged from 50.0 pmol/l in Chinese women to 106.8 pmol/l in Vietnamese women; FSH ranged from 68.2 IU/l in Korean women to 90.8 IU/l in Malay women; and LH ranged from 30.7 IU/l in Korean women to 44.1 IU/l in Malay women. There was an inverse correlation between log E2 and FSH levels and a positive correlation between FSH and LH levels. The concentrations of E2, FSH and LH were significantly associated with ethnicity after adjustment for age and body mass index. Additionally, the concentrations of all three hormones were significantly associated with body mass index, whereas E2 and LH levels were associated with age, but FSH levels were not.

CONCLUSION

The levels of FSH, LH and particularly of E2 differ substantially among ethnic groups of postmenopausal Asian women. The clinical significance, if any, of these differences remains to be investigated. The inverse correlation of E2 and FSH levels suggests that E2 at the postmenopausal state still affects pituitary FSH output.

Authors+Show Affiliations

Wyeth Research, Collegeville, Pennsylvania 19426, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17852146

Citation

Ausmanas, M K., et al. "Estradiol, FSH and LH Profiles in Nine Ethnic Groups of Postmenopausal Asian Women: the Pan-Asia Menopause (PAM) Study." Climacteric : the Journal of the International Menopause Society, vol. 10, no. 5, 2007, pp. 427-37.
Ausmanas MK, Tan DA, Jaisamrarn U, et al. Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study. Climacteric. 2007;10(5):427-37.
Ausmanas, M. K., Tan, D. A., Jaisamrarn, U., Tian, X. W., & Holinka, C. F. (2007). Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study. Climacteric : the Journal of the International Menopause Society, 10(5), 427-37.
Ausmanas MK, et al. Estradiol, FSH and LH Profiles in Nine Ethnic Groups of Postmenopausal Asian Women: the Pan-Asia Menopause (PAM) Study. Climacteric. 2007;10(5):427-37. PubMed PMID: 17852146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study. AU - Ausmanas,M K, AU - Tan,D A, AU - Jaisamrarn,U, AU - Tian,X W, AU - Holinka,C F, PY - 2007/9/14/pubmed PY - 2008/1/16/medline PY - 2007/9/14/entrez SP - 427 EP - 37 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 10 IS - 5 N2 - OBJECTIVES: Significant differences in the prevalence of menopausal symptoms and in lipid profiles have previously been reported for nine ethnic groups of postmenopausal Asian women participating in the Pan-Asia Menopause (PAM) study. Based on these findings, we tested the hypothesis that reproductive hormone profiles differ among the nine ethnic groups under investigation in the PAM study. METHODS: Baseline serum samples from postmenopausal women (n=1020) representing nine ethnic groups were analyzed at a central laboratory by electro-chemiluminescence immunoassay methods. Hormone concentrations were measured for estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH). RESULTS: The hormone levels for the overall study population (mean+/-SD) were: E2=74.1+/-125.1 pmol/l (n=1015); FSH=81.2+/-31.4 IU/l (n=1013); LH=36.8+/-15.6 IU/l (n=1015). Estradiol levels ranged from 50.0 pmol/l in Chinese women to 106.8 pmol/l in Vietnamese women; FSH ranged from 68.2 IU/l in Korean women to 90.8 IU/l in Malay women; and LH ranged from 30.7 IU/l in Korean women to 44.1 IU/l in Malay women. There was an inverse correlation between log E2 and FSH levels and a positive correlation between FSH and LH levels. The concentrations of E2, FSH and LH were significantly associated with ethnicity after adjustment for age and body mass index. Additionally, the concentrations of all three hormones were significantly associated with body mass index, whereas E2 and LH levels were associated with age, but FSH levels were not. CONCLUSION: The levels of FSH, LH and particularly of E2 differ substantially among ethnic groups of postmenopausal Asian women. The clinical significance, if any, of these differences remains to be investigated. The inverse correlation of E2 and FSH levels suggests that E2 at the postmenopausal state still affects pituitary FSH output. SN - 1369-7137 UR - https://www.unboundmedicine.com/medline/citation/17852146/Estradiol_FSH_and_LH_profiles_in_nine_ethnic_groups_of_postmenopausal_Asian_women:_the_Pan_Asia_Menopause__PAM__study_ L2 - https://www.tandfonline.com/doi/full/10.1080/13697130701610780 DB - PRIME DP - Unbound Medicine ER -