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Characteristics of different phenotypes of polycystic ovary syndrome in a Bulgarian population.
Gynecol Endocrinol. 2007 Oct; 23(10):604-9.GE

Abstract

AIM

Our aim was to investigate the percentage occurrence of different phenotypes of polycystic ovary syndrome (PCOS) in a Bulgarian population, and their clinical, biochemical and hormonal characteristics.

METHODS

The study included 70 women with PCOS, diagnosed according to the European Society of Human Reproduction & Embryology/American Society for Reproductive Medicine criteria. The women were divided into four phenotypes: hyperandrogenism (HA) + oligo-/anovulation (OA) + polycystic ovaries at ultrasound (PCO) (full-blown syndrome, phenotype A); HA + OA (former National Institutes of Health definition, phenotype B); OA + PCO (phenotype C); and HA + PCO (phenotype D). Serum levels of testosterone, immune-reactive insulin, sex hormone-binding globulin, dehydroepiandrosterone sulfate and lipid metabolism parameters were measured. Free androgen index and homeostasis model assessment of insulin resistance were calculated. Body mass index and waist-to-hip ratio were assessed.

RESULTS

The percentages of phenotypes A, B, C and D in a Bulgarian population are 58.6%, 11.4%, 10.0% and 20.0%, respectively. The women with the classical form of PCOS (phenotypes A and B) were more obese, had more strongly expressed hyperandrogenemia, and were more insulin-resistant compared with the women of phenotypes C and D.

CONCLUSION

There is a significant difference in anthropometric, hormonal and metabolic indices between the classical form and the clinical variants of PCOS in the studied Bulgarian population.

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Authors+Show Affiliations

Pehlivanov B
Department of Obstetrics and Gynecology, Medical University, Plovdiv, Bulgaria. blago_pehlivanov@yahoo.com
Orbetzova M
No affiliation info available

MeSH

AdultAnovulationBody Mass IndexBulgariaFemaleHirsutismHumansHyperandrogenismInsulin ResistanceMetabolic SyndromePhenotypePolycystic Ovary SyndromePrevalence

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17852429

Citation

Pehlivanov, Blagovest, and Maria Orbetzova. "Characteristics of Different Phenotypes of Polycystic Ovary Syndrome in a Bulgarian Population." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 23, no. 10, 2007, pp. 604-9.
Pehlivanov B, Orbetzova M. Characteristics of different phenotypes of polycystic ovary syndrome in a Bulgarian population. Gynecol Endocrinol. 2007;23(10):604-9.
Pehlivanov, B., & Orbetzova, M. (2007). Characteristics of different phenotypes of polycystic ovary syndrome in a Bulgarian population. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 23(10), 604-9.
Pehlivanov B, Orbetzova M. Characteristics of Different Phenotypes of Polycystic Ovary Syndrome in a Bulgarian Population. Gynecol Endocrinol. 2007;23(10):604-9. PubMed PMID: 17852429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of different phenotypes of polycystic ovary syndrome in a Bulgarian population. AU - Pehlivanov,Blagovest, AU - Orbetzova,Maria, PY - 2007/9/14/pubmed PY - 2008/1/4/medline PY - 2007/9/14/entrez SP - 604 EP - 9 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 23 IS - 10 N2 - AIM: Our aim was to investigate the percentage occurrence of different phenotypes of polycystic ovary syndrome (PCOS) in a Bulgarian population, and their clinical, biochemical and hormonal characteristics. METHODS: The study included 70 women with PCOS, diagnosed according to the European Society of Human Reproduction & Embryology/American Society for Reproductive Medicine criteria. The women were divided into four phenotypes: hyperandrogenism (HA) + oligo-/anovulation (OA) + polycystic ovaries at ultrasound (PCO) (full-blown syndrome, phenotype A); HA + OA (former National Institutes of Health definition, phenotype B); OA + PCO (phenotype C); and HA + PCO (phenotype D). Serum levels of testosterone, immune-reactive insulin, sex hormone-binding globulin, dehydroepiandrosterone sulfate and lipid metabolism parameters were measured. Free androgen index and homeostasis model assessment of insulin resistance were calculated. Body mass index and waist-to-hip ratio were assessed. RESULTS: The percentages of phenotypes A, B, C and D in a Bulgarian population are 58.6%, 11.4%, 10.0% and 20.0%, respectively. The women with the classical form of PCOS (phenotypes A and B) were more obese, had more strongly expressed hyperandrogenemia, and were more insulin-resistant compared with the women of phenotypes C and D. CONCLUSION: There is a significant difference in anthropometric, hormonal and metabolic indices between the classical form and the clinical variants of PCOS in the studied Bulgarian population. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/17852429/Characteristics_of_different_phenotypes_of_polycystic_ovary_syndrome_in_a_Bulgarian_population_ L2 - https://www.tandfonline.com/doi/full/10.1080/09513590701536246 DB - PRIME DP - Unbound Medicine ER -