Tags

Type your tag names separated by a space and hit enter

Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients.
Scand J Infect Dis. 2008; 40(1):59-62.SJ

Abstract

Herpes simplex virus type 2 (HSV-2) infections of the central nervous system (CNS) are rare with meningitis as the most common clinical presentation. We have investigated the clinical spectrum of CNS infections in 49 adult consecutive patients with HSV-2 genome in the cerebrospinal fluid (CSF). HSV-2 in the CSF was determined by polymerase chain reaction (PCR), and patients were diagnosed as encephalitis or meningitis according to predefined clinical criteria by retrospective data information from consecutive clinical journals. The annual crude incidence rate of HSV-2 CNS disease was 0.26 per 100,000. 43 (88%) had meningitis of whom 8 (19%) had recurring lymphocytic meningitis. Six patients (12%) had encephalitis. 11 of 49 patients (22%) had sequelae recorded during follow-up. None died as a result of HSV-2 CNS disease. Thus, the clinical presentation of HSV-2 infection of the CNS is mainly meningitis but encephalitis does occur and neurological sequelae are common. Recurring lymphocytic meningitis is associated with reactivation of HSV-2 and the condition might be underdiagnosed.

Authors+Show Affiliations

From the Department of Infectious Diseases M, Copenhagen University Hospital, Copenhagen, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17852910

Citation

Omland, Lars Haukali, et al. "Herpes Simplex Virus Type 2 Infections of the Central Nervous System: a Retrospective Study of 49 Patients." Scandinavian Journal of Infectious Diseases, vol. 40, no. 1, 2008, pp. 59-62.
Omland LH, Vestergaard BF, Wandall JH. Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients. Scand J Infect Dis. 2008;40(1):59-62.
Omland, L. H., Vestergaard, B. F., & Wandall, J. H. (2008). Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients. Scandinavian Journal of Infectious Diseases, 40(1), 59-62.
Omland LH, Vestergaard BF, Wandall JH. Herpes Simplex Virus Type 2 Infections of the Central Nervous System: a Retrospective Study of 49 Patients. Scand J Infect Dis. 2008;40(1):59-62. PubMed PMID: 17852910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herpes simplex virus type 2 infections of the central nervous system: A retrospective study of 49 patients. AU - Omland,Lars Haukali, AU - Vestergaard,Bent Faber, AU - Wandall,Johan Heugh, Y1 - 2007/07/10/ PY - 2007/9/14/pubmed PY - 2008/4/23/medline PY - 2007/9/14/entrez SP - 59 EP - 62 JF - Scandinavian journal of infectious diseases JO - Scand. J. Infect. Dis. VL - 40 IS - 1 N2 - Herpes simplex virus type 2 (HSV-2) infections of the central nervous system (CNS) are rare with meningitis as the most common clinical presentation. We have investigated the clinical spectrum of CNS infections in 49 adult consecutive patients with HSV-2 genome in the cerebrospinal fluid (CSF). HSV-2 in the CSF was determined by polymerase chain reaction (PCR), and patients were diagnosed as encephalitis or meningitis according to predefined clinical criteria by retrospective data information from consecutive clinical journals. The annual crude incidence rate of HSV-2 CNS disease was 0.26 per 100,000. 43 (88%) had meningitis of whom 8 (19%) had recurring lymphocytic meningitis. Six patients (12%) had encephalitis. 11 of 49 patients (22%) had sequelae recorded during follow-up. None died as a result of HSV-2 CNS disease. Thus, the clinical presentation of HSV-2 infection of the CNS is mainly meningitis but encephalitis does occur and neurological sequelae are common. Recurring lymphocytic meningitis is associated with reactivation of HSV-2 and the condition might be underdiagnosed. SN - 0036-5548 UR - https://www.unboundmedicine.com/medline/citation/17852910/Herpes_simplex_virus_type_2_infections_of_the_central_nervous_system:_A_retrospective_study_of_49_patients_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365540701509881 DB - PRIME DP - Unbound Medicine ER -