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Eremophilane-type sesquiterpenes from Senecio nemorensis.
Planta Med. 2007 Oct; 73(12):1292-7.PM

Abstract

Three new highly oxygenated eremophilane-type sesquiterpenes, 1 beta,10 beta(8,12)-diepoxy-7 beta,11 beta-dihydroxy-8 beta,12 alpha-dimethoxyeremophilane (1), 1 beta,10 beta-epoxy-7 beta-hydroxy-8 alpha-methoxyeremophil-11 alphaH-12,8 beta-olide (2), and 6 beta-isobutyryloxy-8 alpha-hydroxy-1-oxoeremophil-7(11),9-dien-12,8 beta-olide (3), together with nine known compounds (4-12) were isolated from the roots and aerial parts of Senecio nemorensis L. (Compositae). Structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence including IR, HR-ESI-MS, 1D and 2D NMR techniques and were unequivocally confirmed by single-crystal X-ray diffraction experiments. The antimicrobial activity of the isolated compounds 1-3 and 8-12 was tested against Staphylococcus aureus and Candida albicans.

Authors+Show Affiliations

Fei DQ
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Zhang ZX
No affiliation info available
Chen JJ
No affiliation info available
Gao K
No affiliation info available

MeSH

Candida albicansMicrobial Sensitivity TestsMolecular StructurePlants, MedicinalSenecioSesquiterpenesStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17853345

Citation

Fei, Dong-Qing, et al. "Eremophilane-type Sesquiterpenes From Senecio Nemorensis." Planta Medica, vol. 73, no. 12, 2007, pp. 1292-7.
Fei DQ, Zhang ZX, Chen JJ, et al. Eremophilane-type sesquiterpenes from Senecio nemorensis. Planta Med. 2007;73(12):1292-7.
Fei, D. Q., Zhang, Z. X., Chen, J. J., & Gao, K. (2007). Eremophilane-type sesquiterpenes from Senecio nemorensis. Planta Medica, 73(12), 1292-7.
Fei DQ, et al. Eremophilane-type Sesquiterpenes From Senecio Nemorensis. Planta Med. 2007;73(12):1292-7. PubMed PMID: 17853345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eremophilane-type sesquiterpenes from Senecio nemorensis. AU - Fei,Dong-Qing, AU - Zhang,Zhan-Xin, AU - Chen,Jian-Jun, AU - Gao,Kun, Y1 - 2007/09/13/ PY - 2007/9/14/pubmed PY - 2008/1/4/medline PY - 2007/9/14/entrez SP - 1292 EP - 7 JF - Planta medica JO - Planta Med VL - 73 IS - 12 N2 - Three new highly oxygenated eremophilane-type sesquiterpenes, 1 beta,10 beta(8,12)-diepoxy-7 beta,11 beta-dihydroxy-8 beta,12 alpha-dimethoxyeremophilane (1), 1 beta,10 beta-epoxy-7 beta-hydroxy-8 alpha-methoxyeremophil-11 alphaH-12,8 beta-olide (2), and 6 beta-isobutyryloxy-8 alpha-hydroxy-1-oxoeremophil-7(11),9-dien-12,8 beta-olide (3), together with nine known compounds (4-12) were isolated from the roots and aerial parts of Senecio nemorensis L. (Compositae). Structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence including IR, HR-ESI-MS, 1D and 2D NMR techniques and were unequivocally confirmed by single-crystal X-ray diffraction experiments. The antimicrobial activity of the isolated compounds 1-3 and 8-12 was tested against Staphylococcus aureus and Candida albicans. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/17853345/Eremophilane_type_sesquiterpenes_from_Senecio_nemorensis_ DB - PRIME DP - Unbound Medicine ER -