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[The role of omega-3 fatty acids in the treatment of bipolar disorders: the current situation].
Tijdschr Psychiatr. 2007; 49(9):639-47.TP

Abstract

BACKGROUND

There is great interest in the use of omega-3 fatty acids in the treatment of various psychiatric disorders. Epidemiological investigations show that a high consumption of omega-3 fatty acids is in inverse proportion to the prevalence of affective disorders.

AIM

To provide an overview of current research reports on the use of omega-3 fatty acids and bipolar disorders.

METHOD

Medline was searched with the following MeSH terms: 'mood disorders', 'affective disorders', 'bipolar disorders', 'fish oil', 'unsaturated dietary fats', 'omega-3 fatty acids', 'eicosapentaenoic acid', 'docosahexaenoic acid' and 'alpha-linolenic acid'. results To date, articles have been published about four randomized controlled trials and one open-label study. Omega-3 fatty acids, when added to an existing psychopharmacological maintenance treatment for bipolar disorder, can have a slight beneficial effect on depressive symptoms. There is no clear evidence that this combination has a beneficial effect on manic symptoms.

CONCLUSION

Current data on the efficacy of docosahexaenoic acid (dha) and eicosapentaenoic acid (epa) in the treatment of bipolar disorder are insufficient for us to draw definite conclusions that can guide clinical practice. Further investigations are required into the effects of omega-3 fatty acids on the various phases of bipolar disorder.

Authors+Show Affiliations

Universitair Psychiatrisch Centrum-Katholieke Universiteit Leuven, campus Kortenberg, Belgie. christy.sempels@opzrekem.beNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

17853373

Citation

Sempels, C, and P Sienaert. "[The Role of Omega-3 Fatty Acids in the Treatment of Bipolar Disorders: the Current Situation]." Tijdschrift Voor Psychiatrie, vol. 49, no. 9, 2007, pp. 639-47.
Sempels C, Sienaert P. [The role of omega-3 fatty acids in the treatment of bipolar disorders: the current situation]. Tijdschr Psychiatr. 2007;49(9):639-47.
Sempels, C., & Sienaert, P. (2007). [The role of omega-3 fatty acids in the treatment of bipolar disorders: the current situation]. Tijdschrift Voor Psychiatrie, 49(9), 639-47.
Sempels C, Sienaert P. [The Role of Omega-3 Fatty Acids in the Treatment of Bipolar Disorders: the Current Situation]. Tijdschr Psychiatr. 2007;49(9):639-47. PubMed PMID: 17853373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of omega-3 fatty acids in the treatment of bipolar disorders: the current situation]. AU - Sempels,C, AU - Sienaert,P, PY - 2007/9/14/pubmed PY - 2007/12/19/medline PY - 2007/9/14/entrez SP - 639 EP - 47 JF - Tijdschrift voor psychiatrie JO - Tijdschr Psychiatr VL - 49 IS - 9 N2 - BACKGROUND: There is great interest in the use of omega-3 fatty acids in the treatment of various psychiatric disorders. Epidemiological investigations show that a high consumption of omega-3 fatty acids is in inverse proportion to the prevalence of affective disorders. AIM: To provide an overview of current research reports on the use of omega-3 fatty acids and bipolar disorders. METHOD: Medline was searched with the following MeSH terms: 'mood disorders', 'affective disorders', 'bipolar disorders', 'fish oil', 'unsaturated dietary fats', 'omega-3 fatty acids', 'eicosapentaenoic acid', 'docosahexaenoic acid' and 'alpha-linolenic acid'. results To date, articles have been published about four randomized controlled trials and one open-label study. Omega-3 fatty acids, when added to an existing psychopharmacological maintenance treatment for bipolar disorder, can have a slight beneficial effect on depressive symptoms. There is no clear evidence that this combination has a beneficial effect on manic symptoms. CONCLUSION: Current data on the efficacy of docosahexaenoic acid (dha) and eicosapentaenoic acid (epa) in the treatment of bipolar disorder are insufficient for us to draw definite conclusions that can guide clinical practice. Further investigations are required into the effects of omega-3 fatty acids on the various phases of bipolar disorder. SN - 0303-7339 UR - https://www.unboundmedicine.com/medline/citation/17853373/[The_role_of_omega_3_fatty_acids_in_the_treatment_of_bipolar_disorders:_the_current_situation]_ L2 - http://www.tijdschriftvoorpsychiatrie.nl/en/tijdschrift/artikel/TVPart_1663 DB - PRIME DP - Unbound Medicine ER -