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Risk of thromboembolism in 14,000 individuals with coeliac disease.
Br J Haematol 2007; 139(1):121-7BJ

Abstract

The risk of venous thromboembolism (VTE) was examined in individuals with coeliac disease (CD). The Swedish national inpatient register was used to identify 14 207 individuals with a diagnosis of CD (1964-2003). These individuals were matched for age, sex, calendar year and county with 69 048 reference individuals. Cox regression was used to estimate hazard ratios (HRs) for subsequent thromboembolism in individuals with more than 1 year of follow-up and no prior VTE. CD was associated with an increased risk of subsequent VTE (HR = 1.86; 95% confidence interval (CI) 1.54-2.24). The risk increase was restricted to individuals with CD diagnosed in adulthood. Risk estimates were not affected by the presence of diabetes mellitus or concomitant surgery. Compared with inpatients as reference individuals, CD individuals remained at increased risk of subsequent VTE (adjusted HR = 1.27; 95% CI = 1.06-1.52). In conclusion, this study found a statistically significantly positive association between CD and VTE. This modest association might be explained by a combination of surveillance bias and chronic inflammation.

Authors+Show Affiliations

Department of Paediatrics, Orebro University Hospital, and Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. jonasludvigsson@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17854316

Citation

Ludvigsson, Jonas F., et al. "Risk of Thromboembolism in 14,000 Individuals With Coeliac Disease." British Journal of Haematology, vol. 139, no. 1, 2007, pp. 121-7.
Ludvigsson JF, Welander A, Lassila R, et al. Risk of thromboembolism in 14,000 individuals with coeliac disease. Br J Haematol. 2007;139(1):121-7.
Ludvigsson, J. F., Welander, A., Lassila, R., Ekbom, A., & Montgomery, S. M. (2007). Risk of thromboembolism in 14,000 individuals with coeliac disease. British Journal of Haematology, 139(1), pp. 121-7.
Ludvigsson JF, et al. Risk of Thromboembolism in 14,000 Individuals With Coeliac Disease. Br J Haematol. 2007;139(1):121-7. PubMed PMID: 17854316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of thromboembolism in 14,000 individuals with coeliac disease. AU - Ludvigsson,Jonas F, AU - Welander,Adina, AU - Lassila,Riitta, AU - Ekbom,Anders, AU - Montgomery,Scott M, PY - 2007/9/15/pubmed PY - 2007/11/9/medline PY - 2007/9/15/entrez SP - 121 EP - 7 JF - British journal of haematology JO - Br. J. Haematol. VL - 139 IS - 1 N2 - The risk of venous thromboembolism (VTE) was examined in individuals with coeliac disease (CD). The Swedish national inpatient register was used to identify 14 207 individuals with a diagnosis of CD (1964-2003). These individuals were matched for age, sex, calendar year and county with 69 048 reference individuals. Cox regression was used to estimate hazard ratios (HRs) for subsequent thromboembolism in individuals with more than 1 year of follow-up and no prior VTE. CD was associated with an increased risk of subsequent VTE (HR = 1.86; 95% confidence interval (CI) 1.54-2.24). The risk increase was restricted to individuals with CD diagnosed in adulthood. Risk estimates were not affected by the presence of diabetes mellitus or concomitant surgery. Compared with inpatients as reference individuals, CD individuals remained at increased risk of subsequent VTE (adjusted HR = 1.27; 95% CI = 1.06-1.52). In conclusion, this study found a statistically significantly positive association between CD and VTE. This modest association might be explained by a combination of surveillance bias and chronic inflammation. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/17854316/Risk_of_thromboembolism_in_14000_individuals_with_coeliac_disease_ L2 - https://doi.org/10.1111/j.1365-2141.2007.06766.x DB - PRIME DP - Unbound Medicine ER -