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Bronchiolitis obliterans in children: clinical presentation, therapy and long-term follow-up.
J Paediatr Child Health 2008; 44(3):129-33JP

Abstract

AIM

To delineate the predisposing factors, clinical, radiological features and outcomes of bronchiolitis obliterans (BO) in children for minimising morbidity and mortality.

METHODS

Ten children who had BO from July 1995 to July 2005 were retrospectively reviewed at a tertiary paediatric facility in northern Taiwan.

RESULTS

Bronchiolitis obliterans complicated by infections, Stevens-Johnson syndrome was found in eight and two patients, respectively. In children with post-infectious BO, adenoviruses were the most common etiologic agents (7/8). Among them, six patients needed intensive management and five patients needed mechanical ventilation. All patients presented persistent dyspneic respirations and wheezing since the initial lung infection. Initial focal atelectasis (n = 3) on chest radiographs progressed to atelectasis/lobar collapse (n = 8) when the diagnosis of BO was made. After adequate supportive management, atelectatic bronchiectasis was the most common complication (n = 5).

CONCLUSION

Severe adenovirus bronchiolitis and/or pneumonia appear to have higher risk of development of BO in children. In order to minimise associated complications of BO, meticulous respiratory care for preventing pulmonary collapse may be considered in such instances.

Authors+Show Affiliations

Department of Pediatrics, Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17854412

Citation

Chiu, Chih-Yung, et al. "Bronchiolitis Obliterans in Children: Clinical Presentation, Therapy and Long-term Follow-up." Journal of Paediatrics and Child Health, vol. 44, no. 3, 2008, pp. 129-33.
Chiu CY, Wong KS, Huang YC, et al. Bronchiolitis obliterans in children: clinical presentation, therapy and long-term follow-up. J Paediatr Child Health. 2008;44(3):129-33.
Chiu, C. Y., Wong, K. S., Huang, Y. C., & Lin, T. Y. (2008). Bronchiolitis obliterans in children: clinical presentation, therapy and long-term follow-up. Journal of Paediatrics and Child Health, 44(3), pp. 129-33.
Chiu CY, et al. Bronchiolitis Obliterans in Children: Clinical Presentation, Therapy and Long-term Follow-up. J Paediatr Child Health. 2008;44(3):129-33. PubMed PMID: 17854412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchiolitis obliterans in children: clinical presentation, therapy and long-term follow-up. AU - Chiu,Chih-Yung, AU - Wong,Kin-Sun, AU - Huang,Yhu-Chering, AU - Lin,Tzou-Yien, Y1 - 2007/09/14/ PY - 2007/9/15/pubmed PY - 2008/3/21/medline PY - 2007/9/15/entrez SP - 129 EP - 33 JF - Journal of paediatrics and child health JO - J Paediatr Child Health VL - 44 IS - 3 N2 - AIM: To delineate the predisposing factors, clinical, radiological features and outcomes of bronchiolitis obliterans (BO) in children for minimising morbidity and mortality. METHODS: Ten children who had BO from July 1995 to July 2005 were retrospectively reviewed at a tertiary paediatric facility in northern Taiwan. RESULTS: Bronchiolitis obliterans complicated by infections, Stevens-Johnson syndrome was found in eight and two patients, respectively. In children with post-infectious BO, adenoviruses were the most common etiologic agents (7/8). Among them, six patients needed intensive management and five patients needed mechanical ventilation. All patients presented persistent dyspneic respirations and wheezing since the initial lung infection. Initial focal atelectasis (n = 3) on chest radiographs progressed to atelectasis/lobar collapse (n = 8) when the diagnosis of BO was made. After adequate supportive management, atelectatic bronchiectasis was the most common complication (n = 5). CONCLUSION: Severe adenovirus bronchiolitis and/or pneumonia appear to have higher risk of development of BO in children. In order to minimise associated complications of BO, meticulous respiratory care for preventing pulmonary collapse may be considered in such instances. SN - 1440-1754 UR - https://www.unboundmedicine.com/medline/citation/17854412/Bronchiolitis_obliterans_in_children:_clinical_presentation_therapy_and_long_term_follow_up_ L2 - https://doi.org/10.1111/j.1440-1754.2007.01209.x DB - PRIME DP - Unbound Medicine ER -