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Variability in the clinical expression of Parkinson's disease.
J Neurol Sci. 2008 Mar 15; 266(1-2):197-203.JN

Abstract

Parkinsonism is a clinical syndrome characterized by bradykinesia, hypo-/akinesia, muscular rigidity, and resting tremor, mainly caused by Parkinson's disease (PD). Symptoms of PD are due to a progressive loss of nigral neurons causing striatal dopaminergic denervation. However, nigral degeneration is only a part of the underlying synucleinopathy, and clinical symptoms go far beyond motor parkinsonism. Olfactory disturbances, fatigue, pain, autonomic dysfunction, sleep fragmentation, depression, and dementia with or without psychosis are frequently seen. The variability in the expression of these signs and symptoms, as discussed in this paper, might be explained by the specific topographical sequence of the pathology, depending on the extent and progression of the degenerative process at defined sites. Better insight in the clinicopathological correlations of this disease may help to further develop early diagnosis and adequate therapeutic strategies.

Authors+Show Affiliations

Department of Neurology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. e.wolters@vumc.nl

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17854836

Citation

Wolters, Erik Ch. "Variability in the Clinical Expression of Parkinson's Disease." Journal of the Neurological Sciences, vol. 266, no. 1-2, 2008, pp. 197-203.
Wolters ECh. Variability in the clinical expression of Parkinson's disease. J Neurol Sci. 2008;266(1-2):197-203.
Wolters, E. C. h. (2008). Variability in the clinical expression of Parkinson's disease. Journal of the Neurological Sciences, 266(1-2), 197-203.
Wolters ECh. Variability in the Clinical Expression of Parkinson's Disease. J Neurol Sci. 2008 Mar 15;266(1-2):197-203. PubMed PMID: 17854836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variability in the clinical expression of Parkinson's disease. A1 - Wolters,Erik Ch, Y1 - 2007/09/12/ PY - 2007/9/15/pubmed PY - 2008/4/29/medline PY - 2007/9/15/entrez SP - 197 EP - 203 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 266 IS - 1-2 N2 - Parkinsonism is a clinical syndrome characterized by bradykinesia, hypo-/akinesia, muscular rigidity, and resting tremor, mainly caused by Parkinson's disease (PD). Symptoms of PD are due to a progressive loss of nigral neurons causing striatal dopaminergic denervation. However, nigral degeneration is only a part of the underlying synucleinopathy, and clinical symptoms go far beyond motor parkinsonism. Olfactory disturbances, fatigue, pain, autonomic dysfunction, sleep fragmentation, depression, and dementia with or without psychosis are frequently seen. The variability in the expression of these signs and symptoms, as discussed in this paper, might be explained by the specific topographical sequence of the pathology, depending on the extent and progression of the degenerative process at defined sites. Better insight in the clinicopathological correlations of this disease may help to further develop early diagnosis and adequate therapeutic strategies. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17854836/Variability_in_the_clinical_expression_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00578-3 DB - PRIME DP - Unbound Medicine ER -