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What prognostic factors are important for resected intrahepatic cholangiocarcinoma?
J Gastroenterol Hepatol. 2008 May; 23(5):766-70.JG

Abstract

BACKGROUND AND AIM

Our aim was to evaluate the predictive factors for survival and disease-free survival of patients with resected intrahepatic cholangiocarcinoma (ICC).

METHODS

Between October 1994 and 2005, 97 patients with ICC underwent curative hepatic resection. The tumors in 97 patients were reviewed retrospectively to examine the prognosis of ICC.

RESULTS

The 1-, 3- and 5-year survival rates were 74.9%, 51.8% and 31.1%, respectively. The 1-, 3- and 5-year disease-free survival rates were 21.3%, 6.4% and 2.1%, respectively. Univariate analysis showed that tumor size, tumor number, the gross type, resection margin status, T-stage and lymph node involvement were significant prognostic factors. Multiple tumors and cancer cells in the resection margin were found in multivariate analysis to be significantly related to the prognosis. In the multivariate analysis disease free survival was poor for the patients with a large tumor, multiple lesions, a high CA 19-9 level, cancer in the resection margin, advanced T-stage and lymph node involvement.

CONCLUSIONS

The overall 5-year survival rate of ICC was 31.1%. Multiple intrahepatic lesions were a sign of a poor prognosis for ICC. Better survival could be achieved by curative resection with a tumor-free margin.

Authors+Show Affiliations

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17868336

Citation

Paik, Kwang Yeol, et al. "What Prognostic Factors Are Important for Resected Intrahepatic Cholangiocarcinoma?" Journal of Gastroenterology and Hepatology, vol. 23, no. 5, 2008, pp. 766-70.
Paik KY, Jung JC, Heo JS, et al. What prognostic factors are important for resected intrahepatic cholangiocarcinoma? J Gastroenterol Hepatol. 2008;23(5):766-70.
Paik, K. Y., Jung, J. C., Heo, J. S., Choi, S. H., Choi, D. W., & Kim, Y. I. (2008). What prognostic factors are important for resected intrahepatic cholangiocarcinoma? Journal of Gastroenterology and Hepatology, 23(5), 766-70.
Paik KY, et al. What Prognostic Factors Are Important for Resected Intrahepatic Cholangiocarcinoma. J Gastroenterol Hepatol. 2008;23(5):766-70. PubMed PMID: 17868336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What prognostic factors are important for resected intrahepatic cholangiocarcinoma? AU - Paik,Kwang Yeol, AU - Jung,Jun Chul, AU - Heo,Jin Seok, AU - Choi,Seong Ho, AU - Choi,Dong Wook, AU - Kim,Yong Il, Y1 - 2007/09/12/ PY - 2007/9/18/pubmed PY - 2008/8/20/medline PY - 2007/9/18/entrez SP - 766 EP - 70 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 23 IS - 5 N2 - BACKGROUND AND AIM: Our aim was to evaluate the predictive factors for survival and disease-free survival of patients with resected intrahepatic cholangiocarcinoma (ICC). METHODS: Between October 1994 and 2005, 97 patients with ICC underwent curative hepatic resection. The tumors in 97 patients were reviewed retrospectively to examine the prognosis of ICC. RESULTS: The 1-, 3- and 5-year survival rates were 74.9%, 51.8% and 31.1%, respectively. The 1-, 3- and 5-year disease-free survival rates were 21.3%, 6.4% and 2.1%, respectively. Univariate analysis showed that tumor size, tumor number, the gross type, resection margin status, T-stage and lymph node involvement were significant prognostic factors. Multiple tumors and cancer cells in the resection margin were found in multivariate analysis to be significantly related to the prognosis. In the multivariate analysis disease free survival was poor for the patients with a large tumor, multiple lesions, a high CA 19-9 level, cancer in the resection margin, advanced T-stage and lymph node involvement. CONCLUSIONS: The overall 5-year survival rate of ICC was 31.1%. Multiple intrahepatic lesions were a sign of a poor prognosis for ICC. Better survival could be achieved by curative resection with a tumor-free margin. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/17868336/What_prognostic_factors_are_important_for_resected_intrahepatic_cholangiocarcinoma L2 - https://doi.org/10.1111/j.1440-1746.2007.05040.x DB - PRIME DP - Unbound Medicine ER -