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The responses of serum transferrin receptors to iron supplements in subjects with iron-deficiency erythropoiesis and iron-deficiency anaemia.
Br J Nutr 2008; 99(2):416-20BJ

Abstract

We aimed to study the response of serum transferrin receptors (sTfR) to Fe supplementation in women of childbearing age with Fe-deficiency erythropoiesis (IDE) and Fe-deficiency anaemia (IDA). Primary screening was performed in 942 women ranging in age from 18 to 45 years. After Fe-related biochemical indices such as serum ferritin, Zn protoporphyrin and Hb were determined, the subjects were divided into four groups: normal, Fe store depletion, IDE and IDA. A total of 131 women were randomly selected from the normal, IDE and IDA groups. Subsequently, seventy-six women with IDE and IDA were given various doses of Fe (14 mg/d for IDE; 28 mg/d for IDA) with ferrous l-threonate capsules for twelve consecutive weeks. After receiving Fe supplements, the levels of Fe and sTfR were determined at weeks 0, 3, 6, 9 and 12. The levels of sTfR in women of childbearing age with IDE and IDA were significantly higher than those in the normal group. After receiving Fe supplements, the levels of sTfR were significantly decreased in women of childbearing age with IDE and IDA, while the levels of serum ferritin were significantly increased. In conclusion, STfR can be used as a reliable indicator for assessing the efficacy of Fe supplements.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100083, China. linbjmu@bjmu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17868487

Citation

Lin, Xiao-Ming, et al. "The Responses of Serum Transferrin Receptors to Iron Supplements in Subjects With Iron-deficiency Erythropoiesis and Iron-deficiency Anaemia." The British Journal of Nutrition, vol. 99, no. 2, 2008, pp. 416-20.
Lin XM, Tian W, Ma L, et al. The responses of serum transferrin receptors to iron supplements in subjects with iron-deficiency erythropoiesis and iron-deficiency anaemia. Br J Nutr. 2008;99(2):416-20.
Lin, X. M., Tian, W., Ma, L., Long, Z., Zhang, J., Shen, X. Y., & Zhang, X. P. (2008). The responses of serum transferrin receptors to iron supplements in subjects with iron-deficiency erythropoiesis and iron-deficiency anaemia. The British Journal of Nutrition, 99(2), pp. 416-20.
Lin XM, et al. The Responses of Serum Transferrin Receptors to Iron Supplements in Subjects With Iron-deficiency Erythropoiesis and Iron-deficiency Anaemia. Br J Nutr. 2008;99(2):416-20. PubMed PMID: 17868487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The responses of serum transferrin receptors to iron supplements in subjects with iron-deficiency erythropoiesis and iron-deficiency anaemia. AU - Lin,Xiao-Ming, AU - Tian,Wei, AU - Ma,Le, AU - Long,Zhu, AU - Zhang,Juan, AU - Shen,Xiao-Yi, AU - Zhang,Xiao-Peng, Y1 - 2007/09/10/ PY - 2007/9/18/pubmed PY - 2008/3/12/medline PY - 2007/9/18/entrez SP - 416 EP - 20 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 99 IS - 2 N2 - We aimed to study the response of serum transferrin receptors (sTfR) to Fe supplementation in women of childbearing age with Fe-deficiency erythropoiesis (IDE) and Fe-deficiency anaemia (IDA). Primary screening was performed in 942 women ranging in age from 18 to 45 years. After Fe-related biochemical indices such as serum ferritin, Zn protoporphyrin and Hb were determined, the subjects were divided into four groups: normal, Fe store depletion, IDE and IDA. A total of 131 women were randomly selected from the normal, IDE and IDA groups. Subsequently, seventy-six women with IDE and IDA were given various doses of Fe (14 mg/d for IDE; 28 mg/d for IDA) with ferrous l-threonate capsules for twelve consecutive weeks. After receiving Fe supplements, the levels of Fe and sTfR were determined at weeks 0, 3, 6, 9 and 12. The levels of sTfR in women of childbearing age with IDE and IDA were significantly higher than those in the normal group. After receiving Fe supplements, the levels of sTfR were significantly decreased in women of childbearing age with IDE and IDA, while the levels of serum ferritin were significantly increased. In conclusion, STfR can be used as a reliable indicator for assessing the efficacy of Fe supplements. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17868487/The_responses_of_serum_transferrin_receptors_to_iron_supplements_in_subjects_with_iron_deficiency_erythropoiesis_and_iron_deficiency_anaemia_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507797040/type/journal_article DB - PRIME DP - Unbound Medicine ER -