Tags

Type your tag names separated by a space and hit enter

Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative.
Ophthalmology 2008; 115(5):876-883.e1O

Abstract

PURPOSE

To examine the association between intermediate age-related macular degeneration (AMD) and the optical density of macular pigment (MPOD), which is composed of lutein and zeaxanthin from the diet.

DESIGN

Cross-sectional cohort study.

PARTICIPANTS

We included 1698 of 2005 women ages 54 to 86 years and participating in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative.

METHODS

The MPOD was measured noninvasively by heterochromatic flicker photometry. Fundus photographs were taken to document prevalent AMD.

MAIN OUTCOME MEASURES

Intermediate AMD (n = 305) and two subtypes-large drusen (n = 233) and pigmentary abnormalities (n = 157).

RESULTS

After adjusting for covariates, the odds ratio (OR) and 95% confidence interval (CI) for AMD among women in quintile (Q) 5 (n = 339) versus 1 (n = 340) for MPOD was 1.4 (0.9, 2.1). However, after excluding women with possible unstable diets and recent supplement use due to chronic disease history, associations reversed (OR Q2-5 vs. 1, 0.8; 95% CI, 0.5-1.2), but remained nonsignificant. Associations also differed between middle-aged (54-69 years) and older (> or =70 years) women (P-interaction = 0.09), but less so, after excluding women who were likely to have unstable diets: adjusted ORs (95% CI) were 0.5 (0.3-1.0; P = 0.08) for intermediate AMD among middle-aged women (n = 516) with MPOD in Q2 to Q5 versus 1 and 1.0 (0.5-2.0; P = 0.90) for older women (n = 422).

CONCLUSIONS

The MPOD is not cross-sectionally associated with AMD. The inconsistency of relationships across age groups and in subgroups of women who are likely to have more stable diets suggests that cross-sectional associations may be biased and highlights the need to study these relationships prospectively.

Authors+Show Affiliations

Department of Family Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17868874

Citation

LaRowe, Tara L., et al. "Macular Pigment Density and Age-related Maculopathy in the Carotenoids in Age-Related Eye Disease Study. an Ancillary Study of the Women's Health Initiative." Ophthalmology, vol. 115, no. 5, 2008, pp. 876-883.e1.
LaRowe TL, Mares JA, Snodderly DM, et al. Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative. Ophthalmology. 2008;115(5):876-883.e1.
LaRowe, T. L., Mares, J. A., Snodderly, D. M., Klein, M. L., Wooten, B. R., & Chappell, R. (2008). Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative. Ophthalmology, 115(5), pp. 876-883.e1.
LaRowe TL, et al. Macular Pigment Density and Age-related Maculopathy in the Carotenoids in Age-Related Eye Disease Study. an Ancillary Study of the Women's Health Initiative. Ophthalmology. 2008;115(5):876-883.e1. PubMed PMID: 17868874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative. AU - LaRowe,Tara L, AU - Mares,Julie A, AU - Snodderly,D Max, AU - Klein,Michael L, AU - Wooten,Billy R, AU - Chappell,Richard, AU - ,, Y1 - 2007/09/14/ PY - 2007/01/22/received PY - 2007/06/07/revised PY - 2007/06/08/accepted PY - 2007/9/18/pubmed PY - 2008/5/7/medline PY - 2007/9/18/entrez SP - 876 EP - 883.e1 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 5 N2 - PURPOSE: To examine the association between intermediate age-related macular degeneration (AMD) and the optical density of macular pigment (MPOD), which is composed of lutein and zeaxanthin from the diet. DESIGN: Cross-sectional cohort study. PARTICIPANTS: We included 1698 of 2005 women ages 54 to 86 years and participating in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative. METHODS: The MPOD was measured noninvasively by heterochromatic flicker photometry. Fundus photographs were taken to document prevalent AMD. MAIN OUTCOME MEASURES: Intermediate AMD (n = 305) and two subtypes-large drusen (n = 233) and pigmentary abnormalities (n = 157). RESULTS: After adjusting for covariates, the odds ratio (OR) and 95% confidence interval (CI) for AMD among women in quintile (Q) 5 (n = 339) versus 1 (n = 340) for MPOD was 1.4 (0.9, 2.1). However, after excluding women with possible unstable diets and recent supplement use due to chronic disease history, associations reversed (OR Q2-5 vs. 1, 0.8; 95% CI, 0.5-1.2), but remained nonsignificant. Associations also differed between middle-aged (54-69 years) and older (> or =70 years) women (P-interaction = 0.09), but less so, after excluding women who were likely to have unstable diets: adjusted ORs (95% CI) were 0.5 (0.3-1.0; P = 0.08) for intermediate AMD among middle-aged women (n = 516) with MPOD in Q2 to Q5 versus 1 and 1.0 (0.5-2.0; P = 0.90) for older women (n = 422). CONCLUSIONS: The MPOD is not cross-sectionally associated with AMD. The inconsistency of relationships across age groups and in subgroups of women who are likely to have more stable diets suggests that cross-sectional associations may be biased and highlights the need to study these relationships prospectively. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17868874/Macular_pigment_density_and_age_related_maculopathy_in_the_Carotenoids_in_Age_Related_Eye_Disease_Study__An_ancillary_study_of_the_women's_health_initiative_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00667-7 DB - PRIME DP - Unbound Medicine ER -