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Neuropsychological function in children with blood lead levels <10 microg/dL.
Neurotoxicology. 2007 Nov; 28(6):1170-7.N

Abstract

Clear adverse effects of blood lead levels >or=10 microg/dL have been documented in children. Given that the majority of US children have levels below 10 microg/dL, clarification of adverse effects below this cutoff value is needed. Our study evaluated the associations between blood lead levels <10 microg/dL and a broad spectrum of children's cognitive abilities. Data were analyzed from 534 children aged 6-10, enrolled in the New England Children's Amalgam Trial (NECAT) from the urban area of Boston, Massachusetts and rural Farmington, Maine. Adjusting for covariates (age, race, socioeconomic status, and primary caregiver IQ), children with 5-10 microg/dL had 5.0 (S.D. 2.3) points lower IQ scores compared to children with blood lead levels of 1-2 microg/dL (p=0.03). Verbal IQ was more negatively affected than performance IQ, with the most prominent decrement occurring in children's vocabulary. Wechsler Individual Achievement Test scores were strongly negatively associated with blood lead levels of 5-10 microg/dL. In adjusted analyses, children with levels of 5-10 microg/dL scored 7.8 (S.D. 2.4) and 6.9 (S.D. 2.2) points lower on reading and math composite scores, respectively, compared to children with levels of 1-2 microg/dL (p<0.01). Finally, levels of 5-10 microg/dL were associated with decreased attention and working memory. Other than associations of lead exposure with achievement, which even persisted after adjustment for child IQ, the most pronounced deficits were in the areas of spatial attention and executive function. Overall, our analyses support prior research that children's blood levels <10 microg/dL are related to compromised cognition and highlight that these may especially be related to academic achievement.

Authors+Show Affiliations

Department of Environmental Health, Harvard School of Public Health, Landmark Building, 4th Floor, 401 Park Drive, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17868887

Citation

Surkan, Pamela J., et al. "Neuropsychological Function in Children With Blood Lead Levels <10 Microg/dL." Neurotoxicology, vol. 28, no. 6, 2007, pp. 1170-7.
Surkan PJ, Zhang A, Trachtenberg F, et al. Neuropsychological function in children with blood lead levels <10 microg/dL. Neurotoxicology. 2007;28(6):1170-7.
Surkan, P. J., Zhang, A., Trachtenberg, F., Daniel, D. B., McKinlay, S., & Bellinger, D. C. (2007). Neuropsychological function in children with blood lead levels <10 microg/dL. Neurotoxicology, 28(6), 1170-7.
Surkan PJ, et al. Neuropsychological Function in Children With Blood Lead Levels <10 Microg/dL. Neurotoxicology. 2007;28(6):1170-7. PubMed PMID: 17868887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychological function in children with blood lead levels <10 microg/dL. AU - Surkan,Pamela J, AU - Zhang,Annie, AU - Trachtenberg,Felicia, AU - Daniel,David B, AU - McKinlay,Sonja, AU - Bellinger,David C, Y1 - 2007/07/25/ PY - 2007/03/09/received PY - 2007/07/09/revised PY - 2007/07/11/accepted PY - 2007/9/18/pubmed PY - 2008/2/8/medline PY - 2007/9/18/entrez SP - 1170 EP - 7 JF - Neurotoxicology JO - Neurotoxicology VL - 28 IS - 6 N2 - Clear adverse effects of blood lead levels >or=10 microg/dL have been documented in children. Given that the majority of US children have levels below 10 microg/dL, clarification of adverse effects below this cutoff value is needed. Our study evaluated the associations between blood lead levels <10 microg/dL and a broad spectrum of children's cognitive abilities. Data were analyzed from 534 children aged 6-10, enrolled in the New England Children's Amalgam Trial (NECAT) from the urban area of Boston, Massachusetts and rural Farmington, Maine. Adjusting for covariates (age, race, socioeconomic status, and primary caregiver IQ), children with 5-10 microg/dL had 5.0 (S.D. 2.3) points lower IQ scores compared to children with blood lead levels of 1-2 microg/dL (p=0.03). Verbal IQ was more negatively affected than performance IQ, with the most prominent decrement occurring in children's vocabulary. Wechsler Individual Achievement Test scores were strongly negatively associated with blood lead levels of 5-10 microg/dL. In adjusted analyses, children with levels of 5-10 microg/dL scored 7.8 (S.D. 2.4) and 6.9 (S.D. 2.2) points lower on reading and math composite scores, respectively, compared to children with levels of 1-2 microg/dL (p<0.01). Finally, levels of 5-10 microg/dL were associated with decreased attention and working memory. Other than associations of lead exposure with achievement, which even persisted after adjustment for child IQ, the most pronounced deficits were in the areas of spatial attention and executive function. Overall, our analyses support prior research that children's blood levels <10 microg/dL are related to compromised cognition and highlight that these may especially be related to academic achievement. SN - 0161-813X UR - https://www.unboundmedicine.com/medline/citation/17868887/Neuropsychological_function_in_children_with_blood_lead_levels_<10_microg/dL_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(07)00157-X DB - PRIME DP - Unbound Medicine ER -