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[Rheologic findings in patients with diabetic retinopathy].
Fortschr Ophthalmol. 1991; 88(4):321-5.FO

Abstract

The rheological parameters hematocrit, plasma viscosity, red blood cell aggregation and blood cell rigidity were measured in 256 adult-onset (type II) diabetics. The stage of diabetic retinopathy was graded by means of ophthalmoscopy and videofluorescein angiography. The mean values of hematocrit (men 45 +/- 5%, women 42 +/- 5%) and red blood cell rigidity (1.01 +/- 0.08) were equal to those in normal subjects. Plasma viscosity (1.40 +/- 0.10) mPas, normals: 1.24 +/- 0.05 mPas) and red blood cell aggregation (16.0 +/- 4.2, normals: 14.6 +/- 3.2) were increased over the values in normals. The groups with different stages of diabetic retinopathy showed no difference in all rheological parameters. Plasma viscosity and red blood cell aggregation were determined partly by the levels of the large plasma proteins. In the type II diabetics fibrinogen was the most markedly elevated large plasma protein (4.1 +/- 1.2 g/l, normals: 3.2 +/- 0.6 g/l). Significant correlations were found between plasma viscosity and fibrinogen (0.49); plasma viscosity and alpha-2-macroglobulin (0.33); red blood cell aggregation and alpha-2-macroglobulin (0.28); and red blood cell aggregation and immunoglobulin M (0.25). The elevation of red blood cell aggregation and plasma viscosity may be one of the reasons for disturbed microcirculation and fundus changes in diabetic retinopathy.

Authors+Show Affiliations

Augenklinik Medizinischen Einrichtungen der RWTH, Aachen, Bundesrepublik Deutschland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

1786912

Citation

Bertram, B, et al. "[Rheologic Findings in Patients With Diabetic Retinopathy]." Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft, vol. 88, no. 4, 1991, pp. 321-5.
Bertram B, Wolf S, Kaufhold F, et al. [Rheologic findings in patients with diabetic retinopathy]. Fortschr Ophthalmol. 1991;88(4):321-5.
Bertram, B., Wolf, S., Kaufhold, F., Jung, F., Kiesewetter, H., & Reim, M. (1991). [Rheologic findings in patients with diabetic retinopathy]. Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft, 88(4), 321-5.
Bertram B, et al. [Rheologic Findings in Patients With Diabetic Retinopathy]. Fortschr Ophthalmol. 1991;88(4):321-5. PubMed PMID: 1786912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Rheologic findings in patients with diabetic retinopathy]. AU - Bertram,B, AU - Wolf,S, AU - Kaufhold,F, AU - Jung,F, AU - Kiesewetter,H, AU - Reim,M, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 321 EP - 5 JF - Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft JO - Fortschr Ophthalmol VL - 88 IS - 4 N2 - The rheological parameters hematocrit, plasma viscosity, red blood cell aggregation and blood cell rigidity were measured in 256 adult-onset (type II) diabetics. The stage of diabetic retinopathy was graded by means of ophthalmoscopy and videofluorescein angiography. The mean values of hematocrit (men 45 +/- 5%, women 42 +/- 5%) and red blood cell rigidity (1.01 +/- 0.08) were equal to those in normal subjects. Plasma viscosity (1.40 +/- 0.10) mPas, normals: 1.24 +/- 0.05 mPas) and red blood cell aggregation (16.0 +/- 4.2, normals: 14.6 +/- 3.2) were increased over the values in normals. The groups with different stages of diabetic retinopathy showed no difference in all rheological parameters. Plasma viscosity and red blood cell aggregation were determined partly by the levels of the large plasma proteins. In the type II diabetics fibrinogen was the most markedly elevated large plasma protein (4.1 +/- 1.2 g/l, normals: 3.2 +/- 0.6 g/l). Significant correlations were found between plasma viscosity and fibrinogen (0.49); plasma viscosity and alpha-2-macroglobulin (0.33); red blood cell aggregation and alpha-2-macroglobulin (0.28); and red blood cell aggregation and immunoglobulin M (0.25). The elevation of red blood cell aggregation and plasma viscosity may be one of the reasons for disturbed microcirculation and fundus changes in diabetic retinopathy. SN - 0723-8045 UR - https://www.unboundmedicine.com/medline/citation/1786912/[Rheologic_findings_in_patients_with_diabetic_retinopathy]_ L2 - https://medlineplus.gov/diabeticeyeproblems.html DB - PRIME DP - Unbound Medicine ER -