Tags

Type your tag names separated by a space and hit enter

Do holding exercises or antimuscarinics increase maximum voided volume in monosymptomatic nocturnal enuresis? A randomized controlled trial in children.
J Urol. 2007 Nov; 178(5):2132-6.JU

Abstract

PURPOSE

We assessed prospectively the efficacy of holding exercises and/or antimuscarinics (oxybutynin chloride and placebo) for increasing maximum voided volume in prepubertal children with monosymptomatic nocturnal enuresis.

MATERIALS AND METHODS

We randomly allocated 149 children to 5 groups, namely holding exercises with placebo (group A), holding exercises with oxybutynin (group B), placebo alone (group C), oxybutynin alone (group D) and alarm treatment (controls, group E). Maximum voided volume was the greatest voided volume from a 48-hour bladder diary, and holding exercise volume was the greatest volume produced with postponement of voiding after a fluid load, once daily for 4 days. Study medication, holding exercise procedures and alarm treatment were administered for 12 weeks.

RESULTS

Holding exercises combined with placebo or oxybutynin significantly increased holding exercise volume and maximum voided volume, by 25% (p <0.001) and 21% (p <0.01), respectively, in group A, and by 43% (p <0.001) and 41% (p <0.001), respectively, in group B. Medication without holding exercises (groups C and D) did not increase holding exercise volume or maximum voided volume, and in these groups oxybutynin was not significantly superior to placebo. A borderline increase in holding exercise volume did not affect maximum voided volume in group E. Monosymptomatic nocturnal enuresis response was significantly lower with all 4 holding exercise volume modulating treatments (7%) compared to alarm therapy (73%).

CONCLUSIONS

In the treatment of children with monosymptomatic nocturnal enuresis maximum voided volume can be increased significantly through holding exercises, but not with oxybutynin chloride alone. Compared to controls, increasing maximum voided volume had a minimal effect on monosymptomatic nocturnal enuresis.

Authors+Show Affiliations

Department of Pediatrics, University Hospital Antwerp, Antwerp, Belgium. koen.van.hoeck@uza.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17870123

Citation

Van Hoeck, Koen J., et al. "Do Holding Exercises or Antimuscarinics Increase Maximum Voided Volume in Monosymptomatic Nocturnal Enuresis? a Randomized Controlled Trial in Children." The Journal of Urology, vol. 178, no. 5, 2007, pp. 2132-6.
Van Hoeck KJ, Bael A, Van Dessel E, et al. Do holding exercises or antimuscarinics increase maximum voided volume in monosymptomatic nocturnal enuresis? A randomized controlled trial in children. J Urol. 2007;178(5):2132-6.
Van Hoeck, K. J., Bael, A., Van Dessel, E., Van Renthergem, D., Bernaerts, K., Vandermaelen, V., Lax, H., Hirche, H., & van Gool, J. D. (2007). Do holding exercises or antimuscarinics increase maximum voided volume in monosymptomatic nocturnal enuresis? A randomized controlled trial in children. The Journal of Urology, 178(5), 2132-6.
Van Hoeck KJ, et al. Do Holding Exercises or Antimuscarinics Increase Maximum Voided Volume in Monosymptomatic Nocturnal Enuresis? a Randomized Controlled Trial in Children. J Urol. 2007;178(5):2132-6. PubMed PMID: 17870123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do holding exercises or antimuscarinics increase maximum voided volume in monosymptomatic nocturnal enuresis? A randomized controlled trial in children. AU - Van Hoeck,Koen J, AU - Bael,An, AU - Van Dessel,Els, AU - Van Renthergem,Debbie, AU - Bernaerts,Kim, AU - Vandermaelen,Veronique, AU - Lax,Hildegard, AU - Hirche,Herbert, AU - van Gool,Jan D, Y1 - 2007/09/17/ PY - 2007/03/30/received PY - 2007/9/18/pubmed PY - 2007/11/7/medline PY - 2007/9/18/entrez SP - 2132 EP - 6 JF - The Journal of urology JO - J Urol VL - 178 IS - 5 N2 - PURPOSE: We assessed prospectively the efficacy of holding exercises and/or antimuscarinics (oxybutynin chloride and placebo) for increasing maximum voided volume in prepubertal children with monosymptomatic nocturnal enuresis. MATERIALS AND METHODS: We randomly allocated 149 children to 5 groups, namely holding exercises with placebo (group A), holding exercises with oxybutynin (group B), placebo alone (group C), oxybutynin alone (group D) and alarm treatment (controls, group E). Maximum voided volume was the greatest voided volume from a 48-hour bladder diary, and holding exercise volume was the greatest volume produced with postponement of voiding after a fluid load, once daily for 4 days. Study medication, holding exercise procedures and alarm treatment were administered for 12 weeks. RESULTS: Holding exercises combined with placebo or oxybutynin significantly increased holding exercise volume and maximum voided volume, by 25% (p <0.001) and 21% (p <0.01), respectively, in group A, and by 43% (p <0.001) and 41% (p <0.001), respectively, in group B. Medication without holding exercises (groups C and D) did not increase holding exercise volume or maximum voided volume, and in these groups oxybutynin was not significantly superior to placebo. A borderline increase in holding exercise volume did not affect maximum voided volume in group E. Monosymptomatic nocturnal enuresis response was significantly lower with all 4 holding exercise volume modulating treatments (7%) compared to alarm therapy (73%). CONCLUSIONS: In the treatment of children with monosymptomatic nocturnal enuresis maximum voided volume can be increased significantly through holding exercises, but not with oxybutynin chloride alone. Compared to controls, increasing maximum voided volume had a minimal effect on monosymptomatic nocturnal enuresis. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17870123/Do_holding_exercises_or_antimuscarinics_increase_maximum_voided_volume_in_monosymptomatic_nocturnal_enuresis_A_randomized_controlled_trial_in_children_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2007.07.051?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -