Tags

Type your tag names separated by a space and hit enter

Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent.
Neuropharmacology. 2007 Nov; 53(6):741-8.N

Abstract

The purpose of the present study was to investigate whether the anxiolytic-like action of a selective and brain penetrable group I metabotropic glutamate (mGlu5) receptor antagonist 3-[(2-methyl-1,3-tiazol-4-yl)ethynyl]-pyridine (MTEP) is dependent upon the serotonergic system. Experiments were performed on male Wistar rats. The Vogel conflict drinking test was used to detect anxiolytic-like activity. MTEP administered intraperitoneally at doses of 1, 3 and 6 mg/kg induced anxiolytic-like effect. The potential anxiolytic effect of MTEP (1 mg/kg) was inhibited by a nonselective 5-HT receptor antagonist metergoline (2 mg/kg i.p.) and 5-HT2A/2C receptor antagonist ritanserin (0.5 mg/kg i.p.), but not by a 5-HT1A receptor antagonist N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridynyl)cyclohexane-carboxamide (WAY 100635) (0.1 mg/kg i.p). The anxiolytic effect of MTEP (6 mg/kg) was attenuated by ritanserin (1 mg/kg i.p.). Moreover, MTEP-induced a dose-dependent release of serotonin in the frontal cortex. The obtained results suggest that the potential anxiolytic effect of the mGlu5 receptor antagonist MTEP is due to the increased serotonin release with subsequent activation of 5-HT2A/2C receptors, most probably located postsynaptically, but not by the 5-HT1A receptors.

Authors+Show Affiliations

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland. stachow@if-pan.krakow.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17870136

Citation

Stachowicz, K, et al. "Anxiolytic-like Action of MTEP Expressed in the Conflict Drinking Vogel Test in Rats Is Serotonin Dependent." Neuropharmacology, vol. 53, no. 6, 2007, pp. 741-8.
Stachowicz K, Gołembiowska K, Sowa M, et al. Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent. Neuropharmacology. 2007;53(6):741-8.
Stachowicz, K., Gołembiowska, K., Sowa, M., Nowak, G., Chojnacka-Wójcik, E., & Pilc, A. (2007). Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent. Neuropharmacology, 53(6), 741-8.
Stachowicz K, et al. Anxiolytic-like Action of MTEP Expressed in the Conflict Drinking Vogel Test in Rats Is Serotonin Dependent. Neuropharmacology. 2007;53(6):741-8. PubMed PMID: 17870136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent. AU - Stachowicz,K, AU - Gołembiowska,K, AU - Sowa,M, AU - Nowak,G, AU - Chojnacka-Wójcik,E, AU - Pilc,A, Y1 - 2007/08/14/ PY - 2007/03/20/received PY - 2007/08/04/revised PY - 2007/08/06/accepted PY - 2007/9/18/pubmed PY - 2007/12/22/medline PY - 2007/9/18/entrez SP - 741 EP - 8 JF - Neuropharmacology JO - Neuropharmacology VL - 53 IS - 6 N2 - The purpose of the present study was to investigate whether the anxiolytic-like action of a selective and brain penetrable group I metabotropic glutamate (mGlu5) receptor antagonist 3-[(2-methyl-1,3-tiazol-4-yl)ethynyl]-pyridine (MTEP) is dependent upon the serotonergic system. Experiments were performed on male Wistar rats. The Vogel conflict drinking test was used to detect anxiolytic-like activity. MTEP administered intraperitoneally at doses of 1, 3 and 6 mg/kg induced anxiolytic-like effect. The potential anxiolytic effect of MTEP (1 mg/kg) was inhibited by a nonselective 5-HT receptor antagonist metergoline (2 mg/kg i.p.) and 5-HT2A/2C receptor antagonist ritanserin (0.5 mg/kg i.p.), but not by a 5-HT1A receptor antagonist N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridynyl)cyclohexane-carboxamide (WAY 100635) (0.1 mg/kg i.p). The anxiolytic effect of MTEP (6 mg/kg) was attenuated by ritanserin (1 mg/kg i.p.). Moreover, MTEP-induced a dose-dependent release of serotonin in the frontal cortex. The obtained results suggest that the potential anxiolytic effect of the mGlu5 receptor antagonist MTEP is due to the increased serotonin release with subsequent activation of 5-HT2A/2C receptors, most probably located postsynaptically, but not by the 5-HT1A receptors. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/17870136/Anxiolytic_like_action_of_MTEP_expressed_in_the_conflict_drinking_Vogel_test_in_rats_is_serotonin_dependent_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(07)00247-X DB - PRIME DP - Unbound Medicine ER -