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Effects of selenium and vitamin E, in addition to melatonin, against oxidative stress caused by cadmium in rats.
Biol Trace Elem Res. 2007 Aug; 118(2):131-7.BT

Abstract

The present study was carried to evaluate the protective effects of melatonin alone and vitamin E with selenium combination against high dose cadmium-induced oxidative stress in rats. The control group received subcutaneous physiological saline. The first study group administered cadmium chloride (CdCl2) by subcutaneous injection of dose of 1 mg/kg. The second study group administered cadmium plus vitamin E with selenium (1 mg/kg sodium selenite with 60 mg/kg vitamin E); the third study group administered cadmium plus 10 mg/kg melatonin (MLT); the fourth study group administered CdCl2 plus a combination of melatonin in addition to vitamin E and selenium for a month. Determination levels of plasma malondialdehyde (MDA), glutathione peroxidase (GSH-Px), blood superoxide dismutase (SOD), creatinine alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen (BUN), and urea were measured in serum. In only CdCl2 administered group, the MDA, creatinine, ALT, AST, ALP, and urea levels in the serum were significantly higher than the control group (p < 0.05). Whereas in all other groups, this values were significantly lower than the only CdCl2 administered group (p < 0.05). Erythrocytes GSH-Px, serum SOD activities of only CdCl2 received group were significantly lower than the control group (p < 0.05). In conclusion, vitamin E + Se, melatonin and vitamin E, and Se, in addition to MLT combinations, had protective effects against high dose cadmium-induced oxidative damage.

Authors+Show Affiliations

Department of Biology, College of Science, Firat University, Elazig, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17873355

Citation

Konar, Vahit, et al. "Effects of Selenium and Vitamin E, in Addition to Melatonin, Against Oxidative Stress Caused By Cadmium in Rats." Biological Trace Element Research, vol. 118, no. 2, 2007, pp. 131-7.
Konar V, Kara H, Yilmaz M, et al. Effects of selenium and vitamin E, in addition to melatonin, against oxidative stress caused by cadmium in rats. Biol Trace Elem Res. 2007;118(2):131-7.
Konar, V., Kara, H., Yilmaz, M., Dayangac, A., & Karatas, F. (2007). Effects of selenium and vitamin E, in addition to melatonin, against oxidative stress caused by cadmium in rats. Biological Trace Element Research, 118(2), 131-7.
Konar V, et al. Effects of Selenium and Vitamin E, in Addition to Melatonin, Against Oxidative Stress Caused By Cadmium in Rats. Biol Trace Elem Res. 2007;118(2):131-7. PubMed PMID: 17873355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of selenium and vitamin E, in addition to melatonin, against oxidative stress caused by cadmium in rats. AU - Konar,Vahit, AU - Kara,Haki, AU - Yilmaz,Mahmut, AU - Dayangac,Alpaslan, AU - Karatas,Fikret, PY - 2006/07/01/received PY - 2007/01/03/revised PY - 2007/01/08/accepted PY - 2007/9/18/pubmed PY - 2007/12/11/medline PY - 2007/9/18/entrez SP - 131 EP - 7 JF - Biological trace element research JO - Biol Trace Elem Res VL - 118 IS - 2 N2 - The present study was carried to evaluate the protective effects of melatonin alone and vitamin E with selenium combination against high dose cadmium-induced oxidative stress in rats. The control group received subcutaneous physiological saline. The first study group administered cadmium chloride (CdCl2) by subcutaneous injection of dose of 1 mg/kg. The second study group administered cadmium plus vitamin E with selenium (1 mg/kg sodium selenite with 60 mg/kg vitamin E); the third study group administered cadmium plus 10 mg/kg melatonin (MLT); the fourth study group administered CdCl2 plus a combination of melatonin in addition to vitamin E and selenium for a month. Determination levels of plasma malondialdehyde (MDA), glutathione peroxidase (GSH-Px), blood superoxide dismutase (SOD), creatinine alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen (BUN), and urea were measured in serum. In only CdCl2 administered group, the MDA, creatinine, ALT, AST, ALP, and urea levels in the serum were significantly higher than the control group (p < 0.05). Whereas in all other groups, this values were significantly lower than the only CdCl2 administered group (p < 0.05). Erythrocytes GSH-Px, serum SOD activities of only CdCl2 received group were significantly lower than the control group (p < 0.05). In conclusion, vitamin E + Se, melatonin and vitamin E, and Se, in addition to MLT combinations, had protective effects against high dose cadmium-induced oxidative damage. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/17873355/Effects_of_selenium_and_vitamin_E_in_addition_to_melatonin_against_oxidative_stress_caused_by_cadmium_in_rats_ L2 - https://dx.doi.org/10.1007/s12011-007-0009-9 DB - PRIME DP - Unbound Medicine ER -