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Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease.
J Pediatr Gastroenterol Nutr 2007; 45(3):293-300JP

Abstract

INTRODUCTION

Gliadin proteins play a key role in the pathogenesis of celiac disease; however, as a screen for celiac disease, anti-gliadin antibody testing has been replaced by the more sensitive and specific serological assays for transglutaminase autoantibodies (TGAA). A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high sensitivity and specificity.

METHODS

Sera were collected prospectively from children with an increased risk for celiac disease as part of an ongoing study at Denver, and studied for the development of celiac autoimmunity. We investigated the high-performance DGP antibody assay in 50 TGAA-positive children both before the development of celiac autoimmunity and following the institution of a gluten-free diet to determine the relationship of DGP antibodies to TGAA. TGAA were measured by an in-house radioassay.

RESULTS

DGP antibodies and TGAA parallel each other over the period of years children were studied. DGP antibodies resolved sooner than TGAA in subjects on a gluten-free diet. DGP antibodies appeared earlier than TGAA in 9 children.

CONCLUSIONS

Measuring DGP antibodies may be more useful than TGAA in monitoring children on a gluten-free diet. DGP antibodies can precede the appearance of TGAA in some at-risk children.

Authors+Show Affiliations

Section of Gastroenterology, Hepatology and Nutrition, The Children's Hospital, and Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA. edwin.liu@uchsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17873740

Citation

Liu, Edwin, et al. "Natural History of Antibodies to Deamidated Gliadin Peptides and Transglutaminase in Early Childhood Celiac Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 45, no. 3, 2007, pp. 293-300.
Liu E, Li M, Emery L, et al. Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease. J Pediatr Gastroenterol Nutr. 2007;45(3):293-300.
Liu, E., Li, M., Emery, L., Taki, I., Barriga, K., Tiberti, C., ... Hoffenberg, E. J. (2007). Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 45(3), pp. 293-300.
Liu E, et al. Natural History of Antibodies to Deamidated Gliadin Peptides and Transglutaminase in Early Childhood Celiac Disease. J Pediatr Gastroenterol Nutr. 2007;45(3):293-300. PubMed PMID: 17873740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease. AU - Liu,Edwin, AU - Li,Marcella, AU - Emery,Lisa, AU - Taki,Iman, AU - Barriga,Kathy, AU - Tiberti,Claudio, AU - Eisenbarth,George S, AU - Rewers,Marian J, AU - Hoffenberg,Edward J, PY - 2007/9/18/pubmed PY - 2007/10/16/medline PY - 2007/9/18/entrez SP - 293 EP - 300 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 45 IS - 3 N2 - INTRODUCTION: Gliadin proteins play a key role in the pathogenesis of celiac disease; however, as a screen for celiac disease, anti-gliadin antibody testing has been replaced by the more sensitive and specific serological assays for transglutaminase autoantibodies (TGAA). A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high sensitivity and specificity. METHODS: Sera were collected prospectively from children with an increased risk for celiac disease as part of an ongoing study at Denver, and studied for the development of celiac autoimmunity. We investigated the high-performance DGP antibody assay in 50 TGAA-positive children both before the development of celiac autoimmunity and following the institution of a gluten-free diet to determine the relationship of DGP antibodies to TGAA. TGAA were measured by an in-house radioassay. RESULTS: DGP antibodies and TGAA parallel each other over the period of years children were studied. DGP antibodies resolved sooner than TGAA in subjects on a gluten-free diet. DGP antibodies appeared earlier than TGAA in 9 children. CONCLUSIONS: Measuring DGP antibodies may be more useful than TGAA in monitoring children on a gluten-free diet. DGP antibodies can precede the appearance of TGAA in some at-risk children. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/17873740/Natural_history_of_antibodies_to_deamidated_gliadin_peptides_and_transglutaminase_in_early_childhood_celiac_disease_ L2 - http://dx.doi.org/10.1097/MPG.0b013e31806c7b34 DB - PRIME DP - Unbound Medicine ER -