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Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves.

Abstract

We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4'-O-glucoside. At low concentrations olive leaves extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds.

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  • Authors+Show Affiliations

    ,

    CIMO/Escola Superior Agrária, Instituto Politécnico de Bragança, Campus Sta Apolónia, Apt. 1172, 5301-855 Bragança, Portugal.

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    Source

    Molecules (Basel, Switzerland) 12:5 2007 May 26 pg 1153-62

    MeSH

    Anti-Infective Agents
    Chromatography, High Pressure Liquid
    Microbial Sensitivity Tests
    Molecular Structure
    Olea
    Phenols
    Plant Leaves

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17873849

    Citation

    Pereira, Ana Paula, et al. "Phenolic Compounds and Antimicrobial Activity of Olive (Olea Europaea L. Cv. Cobrançosa) Leaves." Molecules (Basel, Switzerland), vol. 12, no. 5, 2007, pp. 1153-62.
    Pereira AP, Ferreira IC, Marcelino F, et al. Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves. Molecules. 2007;12(5):1153-62.
    Pereira, A. P., Ferreira, I. C., Marcelino, F., Valentão, P., Andrade, P. B., Seabra, R., ... Pereira, J. A. (2007). Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves. Molecules (Basel, Switzerland), 12(5), pp. 1153-62.
    Pereira AP, et al. Phenolic Compounds and Antimicrobial Activity of Olive (Olea Europaea L. Cv. Cobrançosa) Leaves. Molecules. 2007 May 26;12(5):1153-62. PubMed PMID: 17873849.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves. AU - Pereira,Ana Paula, AU - Ferreira,Isabel C F R, AU - Marcelino,Filipa, AU - Valentão,Patricia, AU - Andrade,Paula B, AU - Seabra,Rosa, AU - Estevinho,Leticia, AU - Bento,Albino, AU - Pereira,José Alberto, Y1 - 2007/05/26/ PY - 2007/02/23/received PY - 2007/05/24/revised PY - 2007/05/24/accepted PY - 2007/9/18/pubmed PY - 2007/12/7/medline PY - 2007/9/18/entrez SP - 1153 EP - 62 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 12 IS - 5 N2 - We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4'-O-glucoside. At low concentrations olive leaves extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/17873849/Phenolic_compounds_and_antimicrobial_activity_of_olive__Olea_europaea_L__Cv__Cobrançosa__leaves_ L2 - http://www.mdpi.com/resolver?pii=12051153 DB - PRIME DP - Unbound Medicine ER -