TY - JOUR T1 - Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves. AU - Pereira,Ana Paula, AU - Ferreira,Isabel C F R, AU - Marcelino,Filipa, AU - Valentão,Patricia, AU - Andrade,Paula B, AU - Seabra,Rosa, AU - Estevinho,Leticia, AU - Bento,Albino, AU - Pereira,José Alberto, Y1 - 2007/05/26/ PY - 2007/02/23/received PY - 2007/05/24/revised PY - 2007/05/24/accepted PY - 2007/9/18/pubmed PY - 2007/12/7/medline PY - 2007/9/18/entrez SP - 1153 EP - 62 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 12 IS - 5 N2 - We report the determination of phenolic compounds in olive leaves by reversed-phase HPLC/DAD, and the evaluation of their in vitro activity against several microorganisms that may be causal agents of human intestinal and respiratory tract infections, namely gram positive (Bacillus cereus, B. subtilis and Staphylococcus aureus), gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans and Cryptococcus neoformans). Seven phenolic compounds were identified and quantified: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-O-glucoside and luteolin 4'-O-glucoside. At low concentrations olive leaves extracts showed an unusual combined antibacterial and antifungal action, which suggest their great potential as nutraceuticals, particularly as a source of phenolic compounds. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/17873849/Phenolic_compounds_and_antimicrobial_activity_of_olive__Olea_europaea_L__Cv__Cobrançosa__leaves_ L2 - https://www.mdpi.com/resolver?pii=12051153 DB - PRIME DP - Unbound Medicine ER -