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[Study on histogenesis of enterochromaffin-like carcinoid in autoimmune atrophic gastritis associated with pernicious anemia].
Vojnosanit Pregl. 2007 Aug; 64(8):543-8.VP

Abstract

BACKGROUND/AIM

Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA), as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like (ECL) carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A-gastritis associated with PA.

METHODS

During the period from 2000-2006, 65 patients with PA and 30 patients of the control group were examined. Histopathological examination was done in endoscopical biopsies of gastric mucosa fixed in 10% formaldehyde. Paraffin sections were stained with classic hematoxylin-eosin (HE); histochemical AB-PAS (pH 2.5), cytochemical argyrophilic Servier-Munger's and immunocytochemical PAP methods for G cell identification and chromogranin A antibodies - specific marker for neuroendocrine ECL cells. Both G and ECL cells were counted per 20 fields, of surface 0.0245312 mm2 by a field. Basal gastrin serum levels were also examined by using radioimmunoassay (RIA) method. The obtained results were statisticaly calculated by using Student's t test.

RESULTS

Marked antral G cell hyperplasia associated with corporal ECL hyperplasia was found. ECL cell hyperplasia was of simplex, linear, adenomatoid type to the pattern of intramucous ECL cell carcinoid. An average number of G cells was statistically significant in the patients with PA as compared to the control group (p < 0.05) as well as an average number of ECL cells.

CONCLUSION

We concluded that antral G cell hyperplasia accompanied by gastrinemia induces ECL hyperplasia and ECL corporal carcinoid in A-gastritis and that their histogenesis develops trough simple, linear and adenomatoide hyperplasia.

Authors+Show Affiliations

Medicinski fakultet, Klinika za hematologiju, Bulevar Zorana Dindića 48, 18 000 Nis, Srbija. golubovicz@bankerinter.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

srp

PubMed ID

17874722

Citation

Macukanović-Golubović, Lana, et al. "[Study On Histogenesis of Enterochromaffin-like Carcinoid in Autoimmune Atrophic Gastritis Associated With Pernicious Anemia]." Vojnosanitetski Pregled, vol. 64, no. 8, 2007, pp. 543-8.
Macukanović-Golubović L, Katić V, Rancić G, et al. [Study on histogenesis of enterochromaffin-like carcinoid in autoimmune atrophic gastritis associated with pernicious anemia]. Vojnosanit Pregl. 2007;64(8):543-8.
Macukanović-Golubović, L., Katić, V., Rancić, G., Milenović, M., Marjanović, G., & Golubović, Z. (2007). [Study on histogenesis of enterochromaffin-like carcinoid in autoimmune atrophic gastritis associated with pernicious anemia]. Vojnosanitetski Pregled, 64(8), 543-8.
Macukanović-Golubović L, et al. [Study On Histogenesis of Enterochromaffin-like Carcinoid in Autoimmune Atrophic Gastritis Associated With Pernicious Anemia]. Vojnosanit Pregl. 2007;64(8):543-8. PubMed PMID: 17874722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on histogenesis of enterochromaffin-like carcinoid in autoimmune atrophic gastritis associated with pernicious anemia]. AU - Macukanović-Golubović,Lana, AU - Katić,Vuka, AU - Rancić,Gorana, AU - Milenović,Mladen, AU - Marjanović,Goran, AU - Golubović,Zoran, PY - 2007/9/19/pubmed PY - 2007/10/31/medline PY - 2007/9/19/entrez SP - 543 EP - 8 JF - Vojnosanitetski pregled JO - Vojnosanit Pregl VL - 64 IS - 8 N2 - BACKGROUND/AIM: Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA), as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like (ECL) carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A-gastritis associated with PA. METHODS: During the period from 2000-2006, 65 patients with PA and 30 patients of the control group were examined. Histopathological examination was done in endoscopical biopsies of gastric mucosa fixed in 10% formaldehyde. Paraffin sections were stained with classic hematoxylin-eosin (HE); histochemical AB-PAS (pH 2.5), cytochemical argyrophilic Servier-Munger's and immunocytochemical PAP methods for G cell identification and chromogranin A antibodies - specific marker for neuroendocrine ECL cells. Both G and ECL cells were counted per 20 fields, of surface 0.0245312 mm2 by a field. Basal gastrin serum levels were also examined by using radioimmunoassay (RIA) method. The obtained results were statisticaly calculated by using Student's t test. RESULTS: Marked antral G cell hyperplasia associated with corporal ECL hyperplasia was found. ECL cell hyperplasia was of simplex, linear, adenomatoid type to the pattern of intramucous ECL cell carcinoid. An average number of G cells was statistically significant in the patients with PA as compared to the control group (p < 0.05) as well as an average number of ECL cells. CONCLUSION: We concluded that antral G cell hyperplasia accompanied by gastrinemia induces ECL hyperplasia and ECL corporal carcinoid in A-gastritis and that their histogenesis develops trough simple, linear and adenomatoide hyperplasia. SN - 0042-8450 UR - https://www.unboundmedicine.com/medline/citation/17874722/[Study_on_histogenesis_of_enterochromaffin_like_carcinoid_in_autoimmune_atrophic_gastritis_associated_with_pernicious_anemia]_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -