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Steatohepatitis is associated with diabetes and fibrosis in genotype 1b HCV-related chronic liver disease.
J Viral Hepat 2007; 14(10):714-20JV

Abstract

Liver steatosis, diabetes mellitus and hepatitis C virus (HCV) genotype have been implicated in liver fibrosis in HCV-related chronic active hepatitis (CAH). The aim of this study was to evaluate whether steatosis and diabetes were associated with more severe liver fibrosis in patients with genotype 1b HCV-related CAH. One-hundred and eighty patients (98 men, 82 women; age range 17-68 years; median 51) infected with genotype 1b HCV underwent ultrasound examination and liver biopsy because of elevated levels of serum alanine transaminase. Based on liver histology, patients were divided into three steatosis classes: 1 (involving <33% of hepatocytes), 2 (34-66%) and 3 (>66%). Fibrosis was graded with the Ishak score (range: 0-6). Virological and epidemiologic characteristics, biochemical data, body mass index, and apparent duration of disease were recorded. Diabetes was identified according to American Diabetes Association criteria. The median fibrosis grade was 2 (23 patients had liver cirrhosis) in the three steatosis classes, with no significant differences between classes. At multivariate analysis, fibrosis was significantly related to age, alanine transaminase, diabetes, hepatitis B core antibody, steatohepatitis and grading. At binary logistic regression analysis, only diabetes and fibrosis stage were significantly associated with steatohepatitis. Steatosis was not an independent risk factor for liver disease severity in our CAH/genotype 1b HCV-infected patients. Steatohepatitis was associated as well as diabetes and affected the severity of liver fibrosis.

Authors+Show Affiliations

Department of Internal Medicine, Gastroenterology, Hepatology and Endocrinology, Second University of Naples, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17875006

Citation

Masarone, M, et al. "Steatohepatitis Is Associated With Diabetes and Fibrosis in Genotype 1b HCV-related Chronic Liver Disease." Journal of Viral Hepatitis, vol. 14, no. 10, 2007, pp. 714-20.
Masarone M, La Mura V, Bruno S, et al. Steatohepatitis is associated with diabetes and fibrosis in genotype 1b HCV-related chronic liver disease. J Viral Hepat. 2007;14(10):714-20.
Masarone, M., La Mura, V., Bruno, S., Gaeta, G. B., Vecchione, R., Carrino, F., ... Persico, M. (2007). Steatohepatitis is associated with diabetes and fibrosis in genotype 1b HCV-related chronic liver disease. Journal of Viral Hepatitis, 14(10), pp. 714-20.
Masarone M, et al. Steatohepatitis Is Associated With Diabetes and Fibrosis in Genotype 1b HCV-related Chronic Liver Disease. J Viral Hepat. 2007;14(10):714-20. PubMed PMID: 17875006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steatohepatitis is associated with diabetes and fibrosis in genotype 1b HCV-related chronic liver disease. AU - Masarone,M, AU - La Mura,V, AU - Bruno,S, AU - Gaeta,G B, AU - Vecchione,R, AU - Carrino,F, AU - Moschella,F, AU - Torella,R, AU - Persico,M, PY - 2007/9/19/pubmed PY - 2007/12/7/medline PY - 2007/9/19/entrez SP - 714 EP - 20 JF - Journal of viral hepatitis JO - J. Viral Hepat. VL - 14 IS - 10 N2 - Liver steatosis, diabetes mellitus and hepatitis C virus (HCV) genotype have been implicated in liver fibrosis in HCV-related chronic active hepatitis (CAH). The aim of this study was to evaluate whether steatosis and diabetes were associated with more severe liver fibrosis in patients with genotype 1b HCV-related CAH. One-hundred and eighty patients (98 men, 82 women; age range 17-68 years; median 51) infected with genotype 1b HCV underwent ultrasound examination and liver biopsy because of elevated levels of serum alanine transaminase. Based on liver histology, patients were divided into three steatosis classes: 1 (involving <33% of hepatocytes), 2 (34-66%) and 3 (>66%). Fibrosis was graded with the Ishak score (range: 0-6). Virological and epidemiologic characteristics, biochemical data, body mass index, and apparent duration of disease were recorded. Diabetes was identified according to American Diabetes Association criteria. The median fibrosis grade was 2 (23 patients had liver cirrhosis) in the three steatosis classes, with no significant differences between classes. At multivariate analysis, fibrosis was significantly related to age, alanine transaminase, diabetes, hepatitis B core antibody, steatohepatitis and grading. At binary logistic regression analysis, only diabetes and fibrosis stage were significantly associated with steatohepatitis. Steatosis was not an independent risk factor for liver disease severity in our CAH/genotype 1b HCV-infected patients. Steatohepatitis was associated as well as diabetes and affected the severity of liver fibrosis. SN - 1352-0504 UR - https://www.unboundmedicine.com/medline/citation/17875006/Steatohepatitis_is_associated_with_diabetes_and_fibrosis_in_genotype_1b_HCV_related_chronic_liver_disease_ L2 - https://doi.org/10.1111/j.1365-2893.2007.00861.x DB - PRIME DP - Unbound Medicine ER -