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Association between asthma, asthma symptoms and C-reactive protein in US adults: data from the National Health and Nutrition Examination Survey, 1999-2002.
Respirology. 2007 Sep; 12(5):675-82.R

Abstract

BACKGROUND AND OBJECTIVES

CRP is elevated in several inflammatory diseases; however, little is known about its association with asthma.

METHODS

The study evaluated the associations between CRP, asthma and asthma symptoms using data on 8020 adults >or=20 years of age from the latest US National Health and Nutrition Examination Survey.

RESULTS

The prevalence estimates of current asthma, wheezing and nocturnal cough were 3.6% (95% CI: 2.9-4.4), 14.7% (95% CI: 13.7-15.8) and 4.6% (95% CI: 3.8-5.3), respectively. Geometric mean of CRP was 0.20 mg/dL (95% CI: 0.19-0.21). The majority of female (69.5%) respondents were in the fourth (highest) quartile of CRP. Mean CRP levels were significantly higher in non-Hispanic blacks as compared with non-Hispanic whites. The adjusted odds of current asthma and past asthma (as compared with no asthma) were 1.60 (95% CI: 1.02-2.53) and 1.43 (95% CI: 1.07-1.91), respectively, greater in the fourth quartile of CRP. The adjusted odds of presence of both wheezing and nocturnal cough were 2.18 and 3.40 in the third and fourth quartile of CRP, respectively.

CONCLUSIONS

This study shows that adults with asthma and asthma symptoms have higher levels of CRP. The potential use of CRP as a clinically useful marker for asthma severity and control should be further explored.

Authors+Show Affiliations

Texas Tech University Health Sciences Center, Department of Family and Community Medicine, Lubbock, Texas 79416, USA. ahmed.arif@ttuhsc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17875055

Citation

Arif, Ahmed A., et al. "Association Between Asthma, Asthma Symptoms and C-reactive Protein in US Adults: Data From the National Health and Nutrition Examination Survey, 1999-2002." Respirology (Carlton, Vic.), vol. 12, no. 5, 2007, pp. 675-82.
Arif AA, Delclos GL, Colmer-Hamood J. Association between asthma, asthma symptoms and C-reactive protein in US adults: data from the National Health and Nutrition Examination Survey, 1999-2002. Respirology. 2007;12(5):675-82.
Arif, A. A., Delclos, G. L., & Colmer-Hamood, J. (2007). Association between asthma, asthma symptoms and C-reactive protein in US adults: data from the National Health and Nutrition Examination Survey, 1999-2002. Respirology (Carlton, Vic.), 12(5), 675-82.
Arif AA, Delclos GL, Colmer-Hamood J. Association Between Asthma, Asthma Symptoms and C-reactive Protein in US Adults: Data From the National Health and Nutrition Examination Survey, 1999-2002. Respirology. 2007;12(5):675-82. PubMed PMID: 17875055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between asthma, asthma symptoms and C-reactive protein in US adults: data from the National Health and Nutrition Examination Survey, 1999-2002. AU - Arif,Ahmed A, AU - Delclos,George L, AU - Colmer-Hamood,Jane, PY - 2007/9/19/pubmed PY - 2007/12/22/medline PY - 2007/9/19/entrez SP - 675 EP - 82 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 12 IS - 5 N2 - BACKGROUND AND OBJECTIVES: CRP is elevated in several inflammatory diseases; however, little is known about its association with asthma. METHODS: The study evaluated the associations between CRP, asthma and asthma symptoms using data on 8020 adults >or=20 years of age from the latest US National Health and Nutrition Examination Survey. RESULTS: The prevalence estimates of current asthma, wheezing and nocturnal cough were 3.6% (95% CI: 2.9-4.4), 14.7% (95% CI: 13.7-15.8) and 4.6% (95% CI: 3.8-5.3), respectively. Geometric mean of CRP was 0.20 mg/dL (95% CI: 0.19-0.21). The majority of female (69.5%) respondents were in the fourth (highest) quartile of CRP. Mean CRP levels were significantly higher in non-Hispanic blacks as compared with non-Hispanic whites. The adjusted odds of current asthma and past asthma (as compared with no asthma) were 1.60 (95% CI: 1.02-2.53) and 1.43 (95% CI: 1.07-1.91), respectively, greater in the fourth quartile of CRP. The adjusted odds of presence of both wheezing and nocturnal cough were 2.18 and 3.40 in the third and fourth quartile of CRP, respectively. CONCLUSIONS: This study shows that adults with asthma and asthma symptoms have higher levels of CRP. The potential use of CRP as a clinically useful marker for asthma severity and control should be further explored. SN - 1323-7799 UR - https://www.unboundmedicine.com/medline/citation/17875055/Association_between_asthma_asthma_symptoms_and_C_reactive_protein_in_US_adults:_data_from_the_National_Health_and_Nutrition_Examination_Survey_1999_2002_ DB - PRIME DP - Unbound Medicine ER -