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The effect of baseline physical activity on cardiovascular outcomes and new-onset diabetes in patients treated for hypertension and left ventricular hypertrophy: the LIFE study.
J Intern Med. 2007 Oct; 262(4):439-48.JI

Abstract

OBJECTIVES

Physical activity (PA) is a preventive strategy for cardiovascular disease and for managing cardiovascular risk factors. There is little information on the effectiveness of PA for the prevention of cardiovascular outcomes once cardiovascular disease is present. Thus, we studied the relationship between PA at baseline and cardiovascular events in a high-risk population.

DESIGN

A prespecified analyses of observational data in a prospective, randomized hypertension study.

SETTING

Losartan Intervention For Endpoint reduction in hypertension (LIFE) study.

SUBJECTS

Hypertension and left ventricular hypertrophy (LVH) (n = 9,193).

INTERVENTIONS

Losartan versus atenolol.

MAIN OUTCOME MEASURES

Reported level of PA: never exercise, exercise <or=30 min twice per week, or exercise >30 min twice per week at baseline and after a mean of 4.8 years of treatment with losartan- versus atenolol-based therapy. Risk reductions were calculated by level of PA for the primary composite end-point and its components cardiovascular death, stroke and myocardial infarction, and also all-cause mortality and new-onset diabetes.

RESULTS

A modest level of PA (>30 min twice per week) was associated with significant reductions in risk for the primary composite end-point [adjusted hazard ratio (aHR) 0.70, P < 0.001) and its components, all-cause mortality (aHR 0.65, P < 0.001), and new-onset diabetes (aHR 0.66, P < 0.001).

CONCLUSION

A modest level of self-reported PA (>30 min twice per week) in patients with hypertension and LVH in the LIFE study was associated with significant reductions in risk for the primary composite end-point and its components of cardiovascular death, stroke, and myocardial infarction, all-cause mortality, and new-onset diabetes.

Authors+Show Affiliations

Ullevaal University Hospital, University of Oslo, Oslo, Norway. eigil.fossum@medisin.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

17875180

Citation

Fossum, E, et al. "The Effect of Baseline Physical Activity On Cardiovascular Outcomes and New-onset Diabetes in Patients Treated for Hypertension and Left Ventricular Hypertrophy: the LIFE Study." Journal of Internal Medicine, vol. 262, no. 4, 2007, pp. 439-48.
Fossum E, Gleim GW, Kjeldsen SE, et al. The effect of baseline physical activity on cardiovascular outcomes and new-onset diabetes in patients treated for hypertension and left ventricular hypertrophy: the LIFE study. J Intern Med. 2007;262(4):439-48.
Fossum, E., Gleim, G. W., Kjeldsen, S. E., Kizer, J. R., Julius, S., Devereux, R. B., Brady, W. E., Hille, D. A., Lyle, P. A., & Dahlöf, B. (2007). The effect of baseline physical activity on cardiovascular outcomes and new-onset diabetes in patients treated for hypertension and left ventricular hypertrophy: the LIFE study. Journal of Internal Medicine, 262(4), 439-48.
Fossum E, et al. The Effect of Baseline Physical Activity On Cardiovascular Outcomes and New-onset Diabetes in Patients Treated for Hypertension and Left Ventricular Hypertrophy: the LIFE Study. J Intern Med. 2007;262(4):439-48. PubMed PMID: 17875180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of baseline physical activity on cardiovascular outcomes and new-onset diabetes in patients treated for hypertension and left ventricular hypertrophy: the LIFE study. AU - Fossum,E, AU - Gleim,G W, AU - Kjeldsen,S E, AU - Kizer,J R, AU - Julius,S, AU - Devereux,R B, AU - Brady,W E, AU - Hille,D A, AU - Lyle,P A, AU - Dahlöf,B, PY - 2007/9/19/pubmed PY - 2007/11/9/medline PY - 2007/9/19/entrez SP - 439 EP - 48 JF - Journal of internal medicine JO - J Intern Med VL - 262 IS - 4 N2 - OBJECTIVES: Physical activity (PA) is a preventive strategy for cardiovascular disease and for managing cardiovascular risk factors. There is little information on the effectiveness of PA for the prevention of cardiovascular outcomes once cardiovascular disease is present. Thus, we studied the relationship between PA at baseline and cardiovascular events in a high-risk population. DESIGN: A prespecified analyses of observational data in a prospective, randomized hypertension study. SETTING: Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. SUBJECTS: Hypertension and left ventricular hypertrophy (LVH) (n = 9,193). INTERVENTIONS: Losartan versus atenolol. MAIN OUTCOME MEASURES: Reported level of PA: never exercise, exercise <or=30 min twice per week, or exercise >30 min twice per week at baseline and after a mean of 4.8 years of treatment with losartan- versus atenolol-based therapy. Risk reductions were calculated by level of PA for the primary composite end-point and its components cardiovascular death, stroke and myocardial infarction, and also all-cause mortality and new-onset diabetes. RESULTS: A modest level of PA (>30 min twice per week) was associated with significant reductions in risk for the primary composite end-point [adjusted hazard ratio (aHR) 0.70, P < 0.001) and its components, all-cause mortality (aHR 0.65, P < 0.001), and new-onset diabetes (aHR 0.66, P < 0.001). CONCLUSION: A modest level of self-reported PA (>30 min twice per week) in patients with hypertension and LVH in the LIFE study was associated with significant reductions in risk for the primary composite end-point and its components of cardiovascular death, stroke, and myocardial infarction, all-cause mortality, and new-onset diabetes. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/17875180/The_effect_of_baseline_physical_activity_on_cardiovascular_outcomes_and_new_onset_diabetes_in_patients_treated_for_hypertension_and_left_ventricular_hypertrophy:_the_LIFE_study_ DB - PRIME DP - Unbound Medicine ER -