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EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls.
Atherosclerosis. 2008 Apr; 197(2):821-8.A

Abstract

BACKGROUND

Increased blood levels of the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been inversely associated with risk for sudden cardiac death, but their relationship with acute coronary syndromes (ACS) is unclear.

OBJECTIVE

We hypothesized that the EPA+DHA content of blood cell membranes, as a percent of total FAs, is reduced in ACS patients relative to matched controls.

METHODS

We measured the content of EPA+DHA in 768 ACS patients and 768 age-, sex- and race-matched controls. The association with ACS case status of blood cell EPA+DHA [both by a 1 unit change and by category (low, <4%; intermediate 4.1-7.9%; and high, > or =8%)] was assessed using multivariate conditional logistic regression models adjusting for matching variables and smoking status, alcohol use, diabetes, body mass index, serum lipids, education, family history of coronary artery disease, personal histories of myocardial infarction and hypertension, and statin, aspirin, and other antiplatelet drug use.

RESULTS

The combined groups had a mean age of 61+/-12 years, 66% were male, and 92% were Caucasian. The EPA+DHA content was 20% lower in cases than controls (3.4+/-1.6 vs. 4.25+/-2.0%, p<0.001). The multivariable-adjusted odds for case status was 0.77 (95% CI 0.70 to 0.85, p<0.001) for a 1 unit increase in EPA+DHA content. Compared with the lowest EPA+DHA group, the odds ratio for an ACS event was 0.58 (95% CI 0.42-0.80), in the intermediate EPA+DHA group and was 0.31 (95% CI 0.14-0.67; p for trend <0.0001) in the highest EPA+DHA group.

CONCLUSIONS

Odds for ACS case status increased incrementally as the EPA+DHA content decreased suggesting that low EPA+DHA may be associated with increased risk for ACS.

Authors+Show Affiliations

Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, Box 644, 601 Elmwood Avenue, NY 14642, United States. robert block@urmc.rochester.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17875307

Citation

Block, Robert C., et al. "EPA and DHA in Blood Cell Membranes From Acute Coronary Syndrome Patients and Controls." Atherosclerosis, vol. 197, no. 2, 2008, pp. 821-8.
Block RC, Harris WS, Reid KJ, et al. EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. Atherosclerosis. 2008;197(2):821-8.
Block, R. C., Harris, W. S., Reid, K. J., Sands, S. A., & Spertus, J. A. (2008). EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. Atherosclerosis, 197(2), 821-8.
Block RC, et al. EPA and DHA in Blood Cell Membranes From Acute Coronary Syndrome Patients and Controls. Atherosclerosis. 2008;197(2):821-8. PubMed PMID: 17875307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. AU - Block,Robert C, AU - Harris,William S, AU - Reid,Kimberly J, AU - Sands,Scott A, AU - Spertus,John A, Y1 - 2007/09/17/ PY - 2007/04/01/received PY - 2007/07/20/revised PY - 2007/07/27/accepted PY - 2007/9/19/pubmed PY - 2008/4/30/medline PY - 2007/9/19/entrez SP - 821 EP - 8 JF - Atherosclerosis JO - Atherosclerosis VL - 197 IS - 2 N2 - BACKGROUND: Increased blood levels of the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been inversely associated with risk for sudden cardiac death, but their relationship with acute coronary syndromes (ACS) is unclear. OBJECTIVE: We hypothesized that the EPA+DHA content of blood cell membranes, as a percent of total FAs, is reduced in ACS patients relative to matched controls. METHODS: We measured the content of EPA+DHA in 768 ACS patients and 768 age-, sex- and race-matched controls. The association with ACS case status of blood cell EPA+DHA [both by a 1 unit change and by category (low, <4%; intermediate 4.1-7.9%; and high, > or =8%)] was assessed using multivariate conditional logistic regression models adjusting for matching variables and smoking status, alcohol use, diabetes, body mass index, serum lipids, education, family history of coronary artery disease, personal histories of myocardial infarction and hypertension, and statin, aspirin, and other antiplatelet drug use. RESULTS: The combined groups had a mean age of 61+/-12 years, 66% were male, and 92% were Caucasian. The EPA+DHA content was 20% lower in cases than controls (3.4+/-1.6 vs. 4.25+/-2.0%, p<0.001). The multivariable-adjusted odds for case status was 0.77 (95% CI 0.70 to 0.85, p<0.001) for a 1 unit increase in EPA+DHA content. Compared with the lowest EPA+DHA group, the odds ratio for an ACS event was 0.58 (95% CI 0.42-0.80), in the intermediate EPA+DHA group and was 0.31 (95% CI 0.14-0.67; p for trend <0.0001) in the highest EPA+DHA group. CONCLUSIONS: Odds for ACS case status increased incrementally as the EPA+DHA content decreased suggesting that low EPA+DHA may be associated with increased risk for ACS. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/17875307/EPA_and_DHA_in_blood_cell_membranes_from_acute_coronary_syndrome_patients_and_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(07)00476-5 DB - PRIME DP - Unbound Medicine ER -