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Safety of 6-Hz primed low-frequency rTMS in stroke.
Neurorehabil Neural Repair. 2008 Mar-Apr; 22(2):185-92.NN

Abstract

BACKGROUND

Suppression of activity in the contralesional motor cortex may promote recovery of function after stroke. Furthermore, the known depressant effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) can be increased and prolonged by preceding it with 6-Hz priming stimulation.

OBJECTIVE

The authors explored the safety of 6-Hz primed low-frequency rTMS in 10 patients with ischemic stroke.

METHODS

Priming consisted of 10 minutes of 6-Hz rTMS applied to the contralesional hemisphere at 90% of resting motor threshold delivered in 2 trains/min with 5 s/train and 25-second intervals between trains. Low-frequency rTMS consisted of an additional 10 minutes of 1-Hz rTMS at 90% of resting motor threshold without interruption. Possible adverse effects were assessed with the National Institutes of Health Stroke Scale (NIHSS), the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), the Hopkins Verbal Learning Test-Revised (HVLT-R), the Beck Depression Inventory-Second Edition (BDI-II), a finger movement tracking test, and individual self-assessments. Pretest, treatment, and posttest occurred on the first day with follow-up tests on the next 5 weekdays.

RESULTS

There were no seizures and no impairment of NIHSS, WAIS-III, or BDI-II scores. Transient impairment occurred on the HVLT-R. Transient tiredness was common. Occasional reports of headache, neck pain, increased sleep, reduced sleep, nausea, and anxiety occurred.

CONCLUSION

Because there were no major adverse effects, the authors concluded that the treatment was safe for the individuals in this study and that further investigation is now warranted to examine efficacy and safety of serial treatments of 6-Hz primed low-frequency rTMS.

Authors+Show Affiliations

Program in Physical Therapy, University of Minnesota, Minneapolis 55455, USA. carey007@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17876070

Citation

Carey, James R., et al. "Safety of 6-Hz Primed Low-frequency rTMS in Stroke." Neurorehabilitation and Neural Repair, vol. 22, no. 2, 2008, pp. 185-92.
Carey JR, Evans CD, Anderson DC, et al. Safety of 6-Hz primed low-frequency rTMS in stroke. Neurorehabil Neural Repair. 2008;22(2):185-92.
Carey, J. R., Evans, C. D., Anderson, D. C., Bhatt, E., Nagpal, A., Kimberley, T. J., & Pascual-Leone, A. (2008). Safety of 6-Hz primed low-frequency rTMS in stroke. Neurorehabilitation and Neural Repair, 22(2), 185-92.
Carey JR, et al. Safety of 6-Hz Primed Low-frequency rTMS in Stroke. Neurorehabil Neural Repair. 2008 Mar-Apr;22(2):185-92. PubMed PMID: 17876070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety of 6-Hz primed low-frequency rTMS in stroke. AU - Carey,James R, AU - Evans,Chad D, AU - Anderson,David C, AU - Bhatt,Ela, AU - Nagpal,Ashima, AU - Kimberley,Teresa J, AU - Pascual-Leone,Alvaro, Y1 - 2007/09/17/ PY - 2007/9/19/pubmed PY - 2008/6/5/medline PY - 2007/9/19/entrez SP - 185 EP - 92 JF - Neurorehabilitation and neural repair JO - Neurorehabil Neural Repair VL - 22 IS - 2 N2 - BACKGROUND: Suppression of activity in the contralesional motor cortex may promote recovery of function after stroke. Furthermore, the known depressant effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) can be increased and prolonged by preceding it with 6-Hz priming stimulation. OBJECTIVE: The authors explored the safety of 6-Hz primed low-frequency rTMS in 10 patients with ischemic stroke. METHODS: Priming consisted of 10 minutes of 6-Hz rTMS applied to the contralesional hemisphere at 90% of resting motor threshold delivered in 2 trains/min with 5 s/train and 25-second intervals between trains. Low-frequency rTMS consisted of an additional 10 minutes of 1-Hz rTMS at 90% of resting motor threshold without interruption. Possible adverse effects were assessed with the National Institutes of Health Stroke Scale (NIHSS), the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), the Hopkins Verbal Learning Test-Revised (HVLT-R), the Beck Depression Inventory-Second Edition (BDI-II), a finger movement tracking test, and individual self-assessments. Pretest, treatment, and posttest occurred on the first day with follow-up tests on the next 5 weekdays. RESULTS: There were no seizures and no impairment of NIHSS, WAIS-III, or BDI-II scores. Transient impairment occurred on the HVLT-R. Transient tiredness was common. Occasional reports of headache, neck pain, increased sleep, reduced sleep, nausea, and anxiety occurred. CONCLUSION: Because there were no major adverse effects, the authors concluded that the treatment was safe for the individuals in this study and that further investigation is now warranted to examine efficacy and safety of serial treatments of 6-Hz primed low-frequency rTMS. SN - 1545-9683 UR - https://www.unboundmedicine.com/medline/citation/17876070/Safety_of_6_Hz_primed_low_frequency_rTMS_in_stroke_ L2 - https://journals.sagepub.com/doi/10.1177/1545968307305458?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -