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Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice.

Abstract

AIM

To investigate the effects of propolis on bacterial translocation and ultrastructure of intestinal morphology in experimental obstructive jaundice.

METHODS

Thirty Wistar-Albino male rats were randomly divided into three groups, each including 10 animals: group I, sham-operated; group II, ligation and division of the common bile duct (BDL); group III, BDL followed by oral supplementation of propolis 100 mg/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electron microscopic examination on postoperative 7th d after sacrification.

RESULTS

The mean number of villi per centimeter and mean mucosal height of the propolis group were significantly different in the BDL group (P = 0.001 and 0.012, respectively). The electron microscopic changes were also different between these groups. Sham and BDL + propolis groups had similar incidence of bacterial translocation (BT). The BDL group had significantly higher rates of BT as compared with sham and BDL + propolis groups. BT was predominantly detected in MLNs and the most commonly isolated bacteria was Escherichia coli.

CONCLUSION

Propolis showed a significant protective effect on ileal mucosa and reduced bacterial translocation in the experimental obstructive jaundice model. Further studies should be carried out to explain the mechanisms of these effects.

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  • Authors+Show Affiliations

    ,

    4th General Surgery Department, Ankara Training and Research Hospital, S B Ankara Egitim ve Arastirma Hastanesi 4th, Cerrahi Klinigi 06340, Ulucanlar, Ankara, Turkey.

    , , , , , , ,

    Source

    World journal of gastroenterology 13:39 2007 Oct 21 pg 5226-31

    MeSH

    Animals
    Anti-Infective Agents
    Atrophy
    Bacterial Translocation
    Disease Models, Animal
    Escherichia coli
    Intestinal Mucosa
    Jaundice, Obstructive
    Ligation
    Male
    Propolis
    Random Allocation
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17876893

    Citation

    Sabuncuoglu, Mehmet Zafer, et al. "Propolis Reduces Bacterial Translocation and Intestinal Villus Atrophy in Experimental Obstructive Jaundice." World Journal of Gastroenterology, vol. 13, no. 39, 2007, pp. 5226-31.
    Sabuncuoglu M, Kismet K, Kilicoglu S, et al. Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice. World J Gastroenterol. 2007;13(39):5226-31.
    Sabuncuoglu, M., Kismet, K., Kilicoglu, S., Kilicoglu, B., Erel, S., Muratoglu, S., ... Akkus, M. (2007). Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice. World Journal of Gastroenterology, 13(39), pp. 5226-31.
    Sabuncuoglu M, et al. Propolis Reduces Bacterial Translocation and Intestinal Villus Atrophy in Experimental Obstructive Jaundice. World J Gastroenterol. 2007 Oct 21;13(39):5226-31. PubMed PMID: 17876893.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice. AU - Sabuncuoglu,Mehmet Zafer, AU - Kismet,Kemal, AU - Kilicoglu,Sibel Serin, AU - Kilicoglu,Bulent, AU - Erel,Serap, AU - Muratoglu,Sabahattin, AU - Sunay,Asli Elif, AU - Erdemli,Esra, AU - Akkus,Mehmet Ali, PY - 2007/9/19/pubmed PY - 2007/12/6/medline PY - 2007/9/19/entrez SP - 5226 EP - 31 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 13 IS - 39 N2 - AIM: To investigate the effects of propolis on bacterial translocation and ultrastructure of intestinal morphology in experimental obstructive jaundice. METHODS: Thirty Wistar-Albino male rats were randomly divided into three groups, each including 10 animals: group I, sham-operated; group II, ligation and division of the common bile duct (BDL); group III, BDL followed by oral supplementation of propolis 100 mg/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electron microscopic examination on postoperative 7th d after sacrification. RESULTS: The mean number of villi per centimeter and mean mucosal height of the propolis group were significantly different in the BDL group (P = 0.001 and 0.012, respectively). The electron microscopic changes were also different between these groups. Sham and BDL + propolis groups had similar incidence of bacterial translocation (BT). The BDL group had significantly higher rates of BT as compared with sham and BDL + propolis groups. BT was predominantly detected in MLNs and the most commonly isolated bacteria was Escherichia coli. CONCLUSION: Propolis showed a significant protective effect on ileal mucosa and reduced bacterial translocation in the experimental obstructive jaundice model. Further studies should be carried out to explain the mechanisms of these effects. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/17876893/Propolis_reduces_bacterial_translocation_and_intestinal_villus_atrophy_in_experimental_obstructive_jaundice_ L2 - http://www.wjgnet.com/1007-9327/full/v13/i39/5226.htm DB - PRIME DP - Unbound Medicine ER -