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Tolerance of ruminant animals to high dose in-feed administration of a selenium-enriched yeast.
J Anim Sci. 2008 Jan; 86(1):197-204.JA

Abstract

The objective of the study was to determine if there were adverse effects on animal health and performance when a range of ruminant animal species were fed at least 10 times the maximum permitted European Union (EU) Se dietary inclusion rate (0.568 mg of Se/kg of DM) in the form of Se-enriched yeast (SY) derived from a specific strain of Saccharomyces cerevisiae, CNCM I-3060. In a series of studies, dairy cows, beef cattle, calves, and lambs were offered a control diet that contained no Se supplement or a treatment diet that contained the same basal feed ingredients plus a SY supplement that increased total dietary Se from 0.15 to 6.25, 0.20 to 6.74, 0.15 to 5.86, and 0.14 to 6.63 mg of Se/kg of DM, respectively. The inclusion of the SY supplement increased (P < 0.001) whole-blood Se concentrations, reaching maximum mean values of 716, 1,505, 1,377, and 724 ng of Se/mL for dairy cattle, beef cattle, calves, and lambs, respectively. Seleno-methionine accounted for 10% of total whole-blood Se in control animals, whereas the proportion in SY animals ranged between 40 and 75%. Glutathione peroxidase (EC 1.11.1.9) activity was greater (P < 0.05) in SY animals compared with controls. A range of other biochemical and hematological parameters were assessed, but few differences of biological significance were established between treatment groups. There were no differences between treatment groups within each species with regard to animal physical performance or overall animal health. It was concluded that there were no adverse effects on animal health, performance, and voluntary feed intake with the administration of at least 10 times the EU maximum, or approximately 20 times the US Food and Drug Administration permitted concentration of dietary Se in the form of SY derived from a specific strain of Saccharomyces cerevisiae CNCM I-3060.

Authors+Show Affiliations

Animal Science Research Group, School of Agriculture, Policy and Development University of Reading, Earley Gate, Reading RG6 6AR, UK. d.t.juniper@reading.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17878272

Citation

Juniper, D T., et al. "Tolerance of Ruminant Animals to High Dose In-feed Administration of a Selenium-enriched Yeast." Journal of Animal Science, vol. 86, no. 1, 2008, pp. 197-204.
Juniper DT, Phipps RH, Givens DI, et al. Tolerance of ruminant animals to high dose in-feed administration of a selenium-enriched yeast. J Anim Sci. 2008;86(1):197-204.
Juniper, D. T., Phipps, R. H., Givens, D. I., Jones, A. K., Green, C., & Bertin, G. (2008). Tolerance of ruminant animals to high dose in-feed administration of a selenium-enriched yeast. Journal of Animal Science, 86(1), 197-204.
Juniper DT, et al. Tolerance of Ruminant Animals to High Dose In-feed Administration of a Selenium-enriched Yeast. J Anim Sci. 2008;86(1):197-204. PubMed PMID: 17878272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tolerance of ruminant animals to high dose in-feed administration of a selenium-enriched yeast. AU - Juniper,D T, AU - Phipps,R H, AU - Givens,D I, AU - Jones,A K, AU - Green,C, AU - Bertin,G, Y1 - 2007/09/18/ PY - 2007/9/20/pubmed PY - 2008/3/18/medline PY - 2007/9/20/entrez SP - 197 EP - 204 JF - Journal of animal science JO - J Anim Sci VL - 86 IS - 1 N2 - The objective of the study was to determine if there were adverse effects on animal health and performance when a range of ruminant animal species were fed at least 10 times the maximum permitted European Union (EU) Se dietary inclusion rate (0.568 mg of Se/kg of DM) in the form of Se-enriched yeast (SY) derived from a specific strain of Saccharomyces cerevisiae, CNCM I-3060. In a series of studies, dairy cows, beef cattle, calves, and lambs were offered a control diet that contained no Se supplement or a treatment diet that contained the same basal feed ingredients plus a SY supplement that increased total dietary Se from 0.15 to 6.25, 0.20 to 6.74, 0.15 to 5.86, and 0.14 to 6.63 mg of Se/kg of DM, respectively. The inclusion of the SY supplement increased (P < 0.001) whole-blood Se concentrations, reaching maximum mean values of 716, 1,505, 1,377, and 724 ng of Se/mL for dairy cattle, beef cattle, calves, and lambs, respectively. Seleno-methionine accounted for 10% of total whole-blood Se in control animals, whereas the proportion in SY animals ranged between 40 and 75%. Glutathione peroxidase (EC 1.11.1.9) activity was greater (P < 0.05) in SY animals compared with controls. A range of other biochemical and hematological parameters were assessed, but few differences of biological significance were established between treatment groups. There were no differences between treatment groups within each species with regard to animal physical performance or overall animal health. It was concluded that there were no adverse effects on animal health, performance, and voluntary feed intake with the administration of at least 10 times the EU maximum, or approximately 20 times the US Food and Drug Administration permitted concentration of dietary Se in the form of SY derived from a specific strain of Saccharomyces cerevisiae CNCM I-3060. SN - 1525-3163 UR - https://www.unboundmedicine.com/medline/citation/17878272/Tolerance_of_ruminant_animals_to_high_dose_in_feed_administration_of_a_selenium_enriched_yeast_ L2 - https://academic.oup.com/jas/article-lookup/doi/10.2527/jas.2006-773 DB - PRIME DP - Unbound Medicine ER -