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Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons.
Synapse. 2007 Dec; 61(12):978-84.S

Abstract

We examined whether repeated exposure to the noncompetitive NMDA receptor antagonist phencyclidine (PCP) produces enduring changes in dendritic structure in a manner similar to the stimulants cocaine and amphetamine. Adult rats were treated with i.p. injections of PCP (5 mg/kg) or saline, twice a day, for 5 consecutive days, for a total of 4 weeks. One month after the last injection, their brains were removed and processed for Golgi-Cox staining. Prior exposure to PCP increased dendritic spine density in the mPFC and NAcc core, but not in the parietal cortex. These findings, which are similar to those observed after chronic treatment with cocaine and amphetamine, raise the possibility that, despite differences in their mechanisms of action, PCP and stimulant drugs may induce some of their enduring effects via common processes.

Authors+Show Affiliations

Departement of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Quebec, Canada, H4H 1R3. cecilia.flores@mcgill.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17879264

Citation

Flores, Cecilia, et al. "Chronic Phencyclidine Treatment Increases Dendritic Spine Density in Prefrontal Cortex and Nucleus Accumbens Neurons." Synapse (New York, N.Y.), vol. 61, no. 12, 2007, pp. 978-84.
Flores C, Wen X, Labelle-Dumais C, et al. Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons. Synapse. 2007;61(12):978-84.
Flores, C., Wen, X., Labelle-Dumais, C., & Kolb, B. (2007). Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons. Synapse (New York, N.Y.), 61(12), 978-84.
Flores C, et al. Chronic Phencyclidine Treatment Increases Dendritic Spine Density in Prefrontal Cortex and Nucleus Accumbens Neurons. Synapse. 2007;61(12):978-84. PubMed PMID: 17879264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons. AU - Flores,Cecilia, AU - Wen,Xianglan, AU - Labelle-Dumais,Cassandre, AU - Kolb,Bryan, PY - 2007/9/20/pubmed PY - 2008/1/25/medline PY - 2007/9/20/entrez SP - 978 EP - 84 JF - Synapse (New York, N.Y.) JO - Synapse VL - 61 IS - 12 N2 - We examined whether repeated exposure to the noncompetitive NMDA receptor antagonist phencyclidine (PCP) produces enduring changes in dendritic structure in a manner similar to the stimulants cocaine and amphetamine. Adult rats were treated with i.p. injections of PCP (5 mg/kg) or saline, twice a day, for 5 consecutive days, for a total of 4 weeks. One month after the last injection, their brains were removed and processed for Golgi-Cox staining. Prior exposure to PCP increased dendritic spine density in the mPFC and NAcc core, but not in the parietal cortex. These findings, which are similar to those observed after chronic treatment with cocaine and amphetamine, raise the possibility that, despite differences in their mechanisms of action, PCP and stimulant drugs may induce some of their enduring effects via common processes. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/17879264/Chronic_phencyclidine_treatment_increases_dendritic_spine_density_in_prefrontal_cortex_and_nucleus_accumbens_neurons_ DB - PRIME DP - Unbound Medicine ER -