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Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis.
World J Gastroenterol. 2007 Oct 28; 13(40):5380-3.WJ

Abstract

AIM

To elucidate the influences of H pylori infection on oral iron treatment for iron deficiency anemia (IDA).

METHODS

A total of 86 patients were divided into two groups: group A, receiving ferrous succinate combined with triple therapy for H pylori eradication, and group B (control), treated with ferrous succinate only. During treatment of IDA, dynamic changes in hemoglobin (Hb) level, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), serum iron (SI), and serum ferritin (SF) were compared between the groups.

RESULTS

Hb was slightly higher in group A at d 14 after the start of triple therapy for H pylori eradication (P > 0.05). After the therapy, the increase of Hb in group A became significantly faster than that in group B (P < 0.05). At d 56, the mean Hb in group A returned to the normal level, however, in group B, it was lower than that in group A (P < 0.05) although it had also increased compared with that before oral iron treatment. The MCV and MCH in group A recovered to the normal level, and were much higher than those in group B (P < 0.05) at d 21. In Group B, the MCV and MCH remained at lower than normal levels until d 42 after the start of therapy. And then, they reached a plateau in both groups and the differences disappeared (P > 0.05). The SF in group A was higher than that in group B (P < 0.05) 28 d after the treatment and its improvement was quicker in group A (P < 0.05) , and the difference between the two groups was even more significant (P < 0.01) at d 56. The SI in group A was higher than that in group B (P < 0.05) at d 14 and this persisted until d 56 when the follow-up of this research was finished.

CONCLUSION

Treatment of H pylori can enhance the efficacy of ferrous succinate therapy in IDA patients with H pylori-positive chronic gastritis.

Authors+Show Affiliations

Department of Hematology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17879411

Citation

Chen, Lun-Hua, and He-Sheng Luo. "Effects of H Pylori Therapy On Erythrocytic and Iron Parameters in Iron Deficiency Anemia Patients With H Pylori-positive Chronic Gastristis." World Journal of Gastroenterology, vol. 13, no. 40, 2007, pp. 5380-3.
Chen LH, Luo HS. Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis. World J Gastroenterol. 2007;13(40):5380-3.
Chen, L. H., & Luo, H. S. (2007). Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis. World Journal of Gastroenterology, 13(40), 5380-3.
Chen LH, Luo HS. Effects of H Pylori Therapy On Erythrocytic and Iron Parameters in Iron Deficiency Anemia Patients With H Pylori-positive Chronic Gastristis. World J Gastroenterol. 2007 Oct 28;13(40):5380-3. PubMed PMID: 17879411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis. AU - Chen,Lun-Hua, AU - Luo,He-Sheng, PY - 2007/9/20/pubmed PY - 2007/12/6/medline PY - 2007/9/20/entrez SP - 5380 EP - 3 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 13 IS - 40 N2 - AIM: To elucidate the influences of H pylori infection on oral iron treatment for iron deficiency anemia (IDA). METHODS: A total of 86 patients were divided into two groups: group A, receiving ferrous succinate combined with triple therapy for H pylori eradication, and group B (control), treated with ferrous succinate only. During treatment of IDA, dynamic changes in hemoglobin (Hb) level, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), serum iron (SI), and serum ferritin (SF) were compared between the groups. RESULTS: Hb was slightly higher in group A at d 14 after the start of triple therapy for H pylori eradication (P > 0.05). After the therapy, the increase of Hb in group A became significantly faster than that in group B (P < 0.05). At d 56, the mean Hb in group A returned to the normal level, however, in group B, it was lower than that in group A (P < 0.05) although it had also increased compared with that before oral iron treatment. The MCV and MCH in group A recovered to the normal level, and were much higher than those in group B (P < 0.05) at d 21. In Group B, the MCV and MCH remained at lower than normal levels until d 42 after the start of therapy. And then, they reached a plateau in both groups and the differences disappeared (P > 0.05). The SF in group A was higher than that in group B (P < 0.05) 28 d after the treatment and its improvement was quicker in group A (P < 0.05) , and the difference between the two groups was even more significant (P < 0.01) at d 56. The SI in group A was higher than that in group B (P < 0.05) at d 14 and this persisted until d 56 when the follow-up of this research was finished. CONCLUSION: Treatment of H pylori can enhance the efficacy of ferrous succinate therapy in IDA patients with H pylori-positive chronic gastritis. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/17879411/Effects_of_H_pylori_therapy_on_erythrocytic_and_iron_parameters_in_iron_deficiency_anemia_patients_with_H_pylori_positive_chronic_gastristis_ L2 - https://www.wjgnet.com/1007-9327/full/v13/i40/5380.htm DB - PRIME DP - Unbound Medicine ER -