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Association of IGF-1 and IGFBP-3 with lower urinary tract symptoms in the third national health and nutrition examination survey.
Prostate 2007; 67(15):1693-8P

Abstract

BACKGROUND

Benign growth of the prostate is thought to contribute to lower urinary tract symptoms (LUTS) in older men. It is, however, unclear which factors induce prostate growth in these men. We examined the association of insulin-like growth factor (IGF)-1 and its major binding protein IGFBP-3 with LUTS in a representative US study.

METHODS

We included men 60 years and older who participated in the morning session of the Third National Health and Examination Survey (NHANES III) between 1988 and 1994. Men were classified as cases (n = 91) if they reported at least three of four LUTS (nocturia, incomplete emptying, hesitancy, or weak stream) but had not had non-cancer prostate surgery in the past. Controls were men without symptoms and surgery (n = 220). All results were weighted to account for sampling probability in NHANES III. IGF-1 and IGFBP-3 were measured by ELISA and IRMA, respectively.

RESULTS

After mutual adjustment, men in the highest tertile of serum IGF-1 concentration had a non-significantly higher odds of LUTS than men in the lowest tertile (odds ratio (OR) = 3.20; 95% confidence interval (CI) 0.89-11.4; p-trend = 0.09]. A high concentration of IGFBP-3 was inversely related to the odds of LUTS (OR = 0.25; 95% CI 0.08-0.81; p-trend = 0.02).

CONCLUSION

A high IGFBP-3 level might affect LUTS by decreasing the bioavailability of IGF-1 or independent of IGF-1 by up-regulating apoptosis, and, thus, limiting its growth promoting effects on the prostate.

Authors+Show Affiliations

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17879951

Citation

Rohrmann, Sabine, et al. "Association of IGF-1 and IGFBP-3 With Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey." The Prostate, vol. 67, no. 15, 2007, pp. 1693-8.
Rohrmann S, Giovannucci E, Smit E, et al. Association of IGF-1 and IGFBP-3 with lower urinary tract symptoms in the third national health and nutrition examination survey. Prostate. 2007;67(15):1693-8.
Rohrmann, S., Giovannucci, E., Smit, E., & Platz, E. A. (2007). Association of IGF-1 and IGFBP-3 with lower urinary tract symptoms in the third national health and nutrition examination survey. The Prostate, 67(15), pp. 1693-8.
Rohrmann S, et al. Association of IGF-1 and IGFBP-3 With Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey. Prostate. 2007 Nov 1;67(15):1693-8. PubMed PMID: 17879951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of IGF-1 and IGFBP-3 with lower urinary tract symptoms in the third national health and nutrition examination survey. AU - Rohrmann,Sabine, AU - Giovannucci,Edward, AU - Smit,Ellen, AU - Platz,Elizabeth A, PY - 2007/9/21/pubmed PY - 2007/12/19/medline PY - 2007/9/21/entrez SP - 1693 EP - 8 JF - The Prostate JO - Prostate VL - 67 IS - 15 N2 - BACKGROUND: Benign growth of the prostate is thought to contribute to lower urinary tract symptoms (LUTS) in older men. It is, however, unclear which factors induce prostate growth in these men. We examined the association of insulin-like growth factor (IGF)-1 and its major binding protein IGFBP-3 with LUTS in a representative US study. METHODS: We included men 60 years and older who participated in the morning session of the Third National Health and Examination Survey (NHANES III) between 1988 and 1994. Men were classified as cases (n = 91) if they reported at least three of four LUTS (nocturia, incomplete emptying, hesitancy, or weak stream) but had not had non-cancer prostate surgery in the past. Controls were men without symptoms and surgery (n = 220). All results were weighted to account for sampling probability in NHANES III. IGF-1 and IGFBP-3 were measured by ELISA and IRMA, respectively. RESULTS: After mutual adjustment, men in the highest tertile of serum IGF-1 concentration had a non-significantly higher odds of LUTS than men in the lowest tertile (odds ratio (OR) = 3.20; 95% confidence interval (CI) 0.89-11.4; p-trend = 0.09]. A high concentration of IGFBP-3 was inversely related to the odds of LUTS (OR = 0.25; 95% CI 0.08-0.81; p-trend = 0.02). CONCLUSION: A high IGFBP-3 level might affect LUTS by decreasing the bioavailability of IGF-1 or independent of IGF-1 by up-regulating apoptosis, and, thus, limiting its growth promoting effects on the prostate. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/17879951/Association_of_IGF_1_and_IGFBP_3_with_lower_urinary_tract_symptoms_in_the_third_national_health_and_nutrition_examination_survey_ L2 - https://doi.org/10.1002/pros.20659 DB - PRIME DP - Unbound Medicine ER -