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Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis.
Acta Paediatr 2007; 96(10):1521-5AP

Abstract

AIM

To prove the hypothesis that exocrine pancreatic function determines resting energy expenditure (REE) in cystic fibrosis (CF).

METHOD

Thirty-eight CF individuals, 9-34 (19.98 +/- 1.0) years, were divided into three groups: Six pancreatic sufficient patients (PS; group A), 21 pancreatic insufficient patients (PI), whose pulmonary function was comparable to that of group A (group B1) and 11 PI patients, whose pulmonary function was significantly worse than that of group A (group B2). REE was estimated by indirect calorimetry. Predicted REE was based on Schofield equations. Measured REE was expressed as % of the predicted. BMI, BMI z-scores, serum albumin, cholesterol and triglycerides levels were related to REE. Results were expressed as mean +/- standard error.

RESULTS

Groups B1 and B2 had significantly higher REE% (111.7 +/- 2.75% and 119.94 +/- 3.8, respectively) as opposed to group A (98.9 +/- 3.81%; p = 0.022 and 0.035, respectively) whose REE% was similar to that predicted. REE% between group B1 and B2 was not statistically significant. In groups A, B1 and B, mean FEV1% was 86.33 +/- 10.1%, 90.24 +/- 4.39%, 44.54 +/- 3.47%, respectively, mean BMI was 25.6 +/- 2.06, 19.48 +/- 0.64 and 20.09 +/- 8.8, respectively, BMI z-scores were 0.75 +/- 0.51, -0.52 +/- 0.24 and -1.07 +/- 0.37, respectively. Significant correlation was demonstrated between REE%, BMI z-scores and cholesterol levels in group A.

CONCLUSION

Clinically stable CF patients, who had comparable pulmonary function, exhibited increased REE% only in the presence of exocrine pancreatic insufficiency. REE% strongly correlated with BMI z-scores in pancreatic sufficiency. These findings support the hypothesis that pancreatic rather than pulmonary function may determine nutritional status as well as REE in CF.

Authors+Show Affiliations

Second Department of Pediatrics, Aristotle University of Thessaloniki, Greece. tmod@med.auth.grNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17880419

Citation

Moudiou, T, et al. "Effect of Exocrine Pancreatic Function On Resting Energy Expenditure in Cystic Fibrosis." Acta Paediatrica (Oslo, Norway : 1992), vol. 96, no. 10, 2007, pp. 1521-5.
Moudiou T, Galli-Tsinopoulou A, Nousia-Arvanitakis S. Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis. Acta Paediatr. 2007;96(10):1521-5.
Moudiou, T., Galli-Tsinopoulou, A., & Nousia-Arvanitakis, S. (2007). Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis. Acta Paediatrica (Oslo, Norway : 1992), 96(10), pp. 1521-5.
Moudiou T, Galli-Tsinopoulou A, Nousia-Arvanitakis S. Effect of Exocrine Pancreatic Function On Resting Energy Expenditure in Cystic Fibrosis. Acta Paediatr. 2007;96(10):1521-5. PubMed PMID: 17880419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of exocrine pancreatic function on resting energy expenditure in cystic fibrosis. AU - Moudiou,T, AU - Galli-Tsinopoulou,A, AU - Nousia-Arvanitakis,S, PY - 2007/9/21/pubmed PY - 2008/1/26/medline PY - 2007/9/21/entrez SP - 1521 EP - 5 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 96 IS - 10 N2 - AIM: To prove the hypothesis that exocrine pancreatic function determines resting energy expenditure (REE) in cystic fibrosis (CF). METHOD: Thirty-eight CF individuals, 9-34 (19.98 +/- 1.0) years, were divided into three groups: Six pancreatic sufficient patients (PS; group A), 21 pancreatic insufficient patients (PI), whose pulmonary function was comparable to that of group A (group B1) and 11 PI patients, whose pulmonary function was significantly worse than that of group A (group B2). REE was estimated by indirect calorimetry. Predicted REE was based on Schofield equations. Measured REE was expressed as % of the predicted. BMI, BMI z-scores, serum albumin, cholesterol and triglycerides levels were related to REE. Results were expressed as mean +/- standard error. RESULTS: Groups B1 and B2 had significantly higher REE% (111.7 +/- 2.75% and 119.94 +/- 3.8, respectively) as opposed to group A (98.9 +/- 3.81%; p = 0.022 and 0.035, respectively) whose REE% was similar to that predicted. REE% between group B1 and B2 was not statistically significant. In groups A, B1 and B, mean FEV1% was 86.33 +/- 10.1%, 90.24 +/- 4.39%, 44.54 +/- 3.47%, respectively, mean BMI was 25.6 +/- 2.06, 19.48 +/- 0.64 and 20.09 +/- 8.8, respectively, BMI z-scores were 0.75 +/- 0.51, -0.52 +/- 0.24 and -1.07 +/- 0.37, respectively. Significant correlation was demonstrated between REE%, BMI z-scores and cholesterol levels in group A. CONCLUSION: Clinically stable CF patients, who had comparable pulmonary function, exhibited increased REE% only in the presence of exocrine pancreatic insufficiency. REE% strongly correlated with BMI z-scores in pancreatic sufficiency. These findings support the hypothesis that pancreatic rather than pulmonary function may determine nutritional status as well as REE in CF. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/17880419/Effect_of_exocrine_pancreatic_function_on_resting_energy_expenditure_in_cystic_fibrosis_ L2 - https://doi.org/10.1111/j.1651-2227.2007.00478.x DB - PRIME DP - Unbound Medicine ER -