Tags

Type your tag names separated by a space and hit enter

Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats.
Exp Neurol. 2007 Nov; 208(1):120-6.EN

Abstract

Epidemiological studies suggest that some pesticides might constitute a risk factor for Parkinson's disease (PD). However, risk assessment cannot be performed in the current experimental animal models because they use non-natural pathways of pesticide exposure, such as intraperitoneal or intravenous injection, that might bypass body defences. A new model based on daily inoculation of neurotoxins in the nasal cavity of C57BL/6 mice for 30 days was used to evaluate risk of three complex I inhibitors, 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP), rotenone and paraquat. These compounds displayed very different effects on motor activity, striatal dopamine and dihydroxyphenylacetic acid (DOPAC) levels and loss of dopaminergic neurons. MPTP-treated mice developed motor deficits that correlated with a severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase staining in substantia nigra and striatum. By contrast, rotenone-treated mice or rats were asymptomatic. Paraquat induced severe hypokinesia and vestibular damage but did not alter the nigrostriatal system. The new animal model described here, based on chronic intranasal inoculation of neurotoxicants, provides a new tool to assess the potential danger of environmental toxins as risk factors for development of PD.

Authors+Show Affiliations

Instituto de Investigaciones Biomédicas, Departamento de Bioquímica Facultad de Medicina, and Centro de investigación en Red en Enfermedades Neurodegenerativas (CIBERNED), Universidad Autónoma de Madrid, 28029 Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17880941

Citation

Rojo, Ana I., et al. "Chronic Inhalation of Rotenone or Paraquat Does Not Induce Parkinson's Disease Symptoms in Mice or Rats." Experimental Neurology, vol. 208, no. 1, 2007, pp. 120-6.
Rojo AI, Cavada C, de Sagarra MR, et al. Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Exp Neurol. 2007;208(1):120-6.
Rojo, A. I., Cavada, C., de Sagarra, M. R., & Cuadrado, A. (2007). Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Experimental Neurology, 208(1), 120-6.
Rojo AI, et al. Chronic Inhalation of Rotenone or Paraquat Does Not Induce Parkinson's Disease Symptoms in Mice or Rats. Exp Neurol. 2007;208(1):120-6. PubMed PMID: 17880941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. AU - Rojo,Ana I, AU - Cavada,Carmen, AU - de Sagarra,María Rosa, AU - Cuadrado,Antonio, Y1 - 2007/08/22/ PY - 2007/03/29/received PY - 2007/07/24/revised PY - 2007/07/30/accepted PY - 2007/9/21/pubmed PY - 2008/1/18/medline PY - 2007/9/21/entrez SP - 120 EP - 6 JF - Experimental neurology JO - Exp Neurol VL - 208 IS - 1 N2 - Epidemiological studies suggest that some pesticides might constitute a risk factor for Parkinson's disease (PD). However, risk assessment cannot be performed in the current experimental animal models because they use non-natural pathways of pesticide exposure, such as intraperitoneal or intravenous injection, that might bypass body defences. A new model based on daily inoculation of neurotoxins in the nasal cavity of C57BL/6 mice for 30 days was used to evaluate risk of three complex I inhibitors, 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP), rotenone and paraquat. These compounds displayed very different effects on motor activity, striatal dopamine and dihydroxyphenylacetic acid (DOPAC) levels and loss of dopaminergic neurons. MPTP-treated mice developed motor deficits that correlated with a severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase staining in substantia nigra and striatum. By contrast, rotenone-treated mice or rats were asymptomatic. Paraquat induced severe hypokinesia and vestibular damage but did not alter the nigrostriatal system. The new animal model described here, based on chronic intranasal inoculation of neurotoxicants, provides a new tool to assess the potential danger of environmental toxins as risk factors for development of PD. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/17880941/Chronic_inhalation_of_rotenone_or_paraquat_does_not_induce_Parkinson's_disease_symptoms_in_mice_or_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(07)00300-7 DB - PRIME DP - Unbound Medicine ER -