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Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats.
Food Chem Toxicol. 2008 Jan; 46(1):212-9.FC

Abstract

Reactive oxygen species are implicated as mediators of tissue damage in the acute renal failure induced by inorganic mercury. Astaxanthin (ASX), a carotenoid with potent antioxidant properties, exists naturally in various plants, algae, and seafoods. This paper evaluated the ability of ASX to prevent HgCl(2) nephrotoxicity. Rats were injected with HgCl(2) (0 or 5 mg/kg b.w., sc) 6h after ASX had been administered (0, 10, 25, or 50mg/kg, by gavage) and were killed 12h after HgCl(2) exposure. Although ASX prevented the increase of lipid and protein oxidation and attenuated histopathological changes caused by HgCl(2) in kidney, it did not prevent creatinine increase in plasma and delta-aminolevulinic acid dehydratase inhibition induced by HgCl(2). Glutathione peroxidase and catalase activities were enhanced, while superoxide dismutase activity was depressed in HgCl(2)-treated rats when compared to control and these effects were prevented by ASX. Our results indicate that ASX could have a beneficial role against HgCl(2) toxicity by preventing lipid and protein oxidation, changes in the activity of antioxidant enzymes and histopathological changes.

Authors+Show Affiliations

Post-graduate Program on Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17881112

Citation

Augusti, P R., et al. "Effect of Astaxanthin On Kidney Function Impairment and Oxidative Stress Induced By Mercuric Chloride in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 1, 2008, pp. 212-9.
Augusti PR, Conterato GM, Somacal S, et al. Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Food Chem Toxicol. 2008;46(1):212-9.
Augusti, P. R., Conterato, G. M., Somacal, S., Sobieski, R., Spohr, P. R., Torres, J. V., Charão, M. F., Moro, A. M., Rocha, M. P., Garcia, S. C., & Emanuelli, T. (2008). Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(1), 212-9.
Augusti PR, et al. Effect of Astaxanthin On Kidney Function Impairment and Oxidative Stress Induced By Mercuric Chloride in Rats. Food Chem Toxicol. 2008;46(1):212-9. PubMed PMID: 17881112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats. AU - Augusti,P R, AU - Conterato,G M M, AU - Somacal,S, AU - Sobieski,R, AU - Spohr,P R, AU - Torres,J V, AU - Charão,M F, AU - Moro,A M, AU - Rocha,M P, AU - Garcia,S C, AU - Emanuelli,T, Y1 - 2007/08/14/ PY - 2007/02/03/received PY - 2007/07/21/revised PY - 2007/08/01/accepted PY - 2007/9/21/pubmed PY - 2008/3/12/medline PY - 2007/9/21/entrez SP - 212 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 46 IS - 1 N2 - Reactive oxygen species are implicated as mediators of tissue damage in the acute renal failure induced by inorganic mercury. Astaxanthin (ASX), a carotenoid with potent antioxidant properties, exists naturally in various plants, algae, and seafoods. This paper evaluated the ability of ASX to prevent HgCl(2) nephrotoxicity. Rats were injected with HgCl(2) (0 or 5 mg/kg b.w., sc) 6h after ASX had been administered (0, 10, 25, or 50mg/kg, by gavage) and were killed 12h after HgCl(2) exposure. Although ASX prevented the increase of lipid and protein oxidation and attenuated histopathological changes caused by HgCl(2) in kidney, it did not prevent creatinine increase in plasma and delta-aminolevulinic acid dehydratase inhibition induced by HgCl(2). Glutathione peroxidase and catalase activities were enhanced, while superoxide dismutase activity was depressed in HgCl(2)-treated rats when compared to control and these effects were prevented by ASX. Our results indicate that ASX could have a beneficial role against HgCl(2) toxicity by preventing lipid and protein oxidation, changes in the activity of antioxidant enzymes and histopathological changes. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/17881112/Effect_of_astaxanthin_on_kidney_function_impairment_and_oxidative_stress_induced_by_mercuric_chloride_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(07)00278-5 DB - PRIME DP - Unbound Medicine ER -