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An analysis of genetic studies of Parkinson's disease in Africa.
Parkinsonism Relat Disord. 2008; 14(3):177-82.PR

Abstract

Online databases (till April 30, 2007) revealed 12 studies describing genetics of Parkinson's disease (PD) in Africa. Two studied inheritance patterns of familial PD. Ten focused on one of three genes, i.e. parkin, PINK 1 and LRRK2 in familial PD. Most studies were from North Africa, where parkin mutations are the most common cause of autosomal recessive PD. Frequency of LRRK2 G2019S mutation is higher than North American and European populations. The LRRK2 G2019S mutation is frequent in apparently sporadic PD in North Africans. There is a need to extend research into genetics of sporadic and familial PD to more African subregions.

Authors+Show Affiliations

Neurology Unit, Department of Medicine, College of Medicine, University of Lagos, Lagos State, Nigeria. njide_okubadejo@yahoo.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17881276

Citation

Okubadejo, Njideka U.. "An Analysis of Genetic Studies of Parkinson's Disease in Africa." Parkinsonism & Related Disorders, vol. 14, no. 3, 2008, pp. 177-82.
Okubadejo NU. An analysis of genetic studies of Parkinson's disease in Africa. Parkinsonism Relat Disord. 2008;14(3):177-82.
Okubadejo, N. U. (2008). An analysis of genetic studies of Parkinson's disease in Africa. Parkinsonism & Related Disorders, 14(3), 177-82.
Okubadejo NU. An Analysis of Genetic Studies of Parkinson's Disease in Africa. Parkinsonism Relat Disord. 2008;14(3):177-82. PubMed PMID: 17881276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An analysis of genetic studies of Parkinson's disease in Africa. A1 - Okubadejo,Njideka U, Y1 - 2007/09/18/ PY - 2007/06/01/received PY - 2007/08/14/revised PY - 2007/08/14/accepted PY - 2007/9/21/pubmed PY - 2008/8/14/medline PY - 2007/9/21/entrez SP - 177 EP - 82 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 14 IS - 3 N2 - Online databases (till April 30, 2007) revealed 12 studies describing genetics of Parkinson's disease (PD) in Africa. Two studied inheritance patterns of familial PD. Ten focused on one of three genes, i.e. parkin, PINK 1 and LRRK2 in familial PD. Most studies were from North Africa, where parkin mutations are the most common cause of autosomal recessive PD. Frequency of LRRK2 G2019S mutation is higher than North American and European populations. The LRRK2 G2019S mutation is frequent in apparently sporadic PD in North Africans. There is a need to extend research into genetics of sporadic and familial PD to more African subregions. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/17881276/An_analysis_of_genetic_studies_of_Parkinson's_disease_in_Africa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(07)00177-0 DB - PRIME DP - Unbound Medicine ER -