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Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats.
Eur J Pharmacol. 2007 Dec 08; 576(1-3):77-82.EJ

Abstract

The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at doses of 10 and 20 mg/kg, and a significant increase was also observed in reference memory errors at a dose of 20 mg/kg. Diphenhydramine and chlorphenilamine at a dose of 20 mg/kg and triprolidine at a dose of 35 mg/kg also caused significant increases in the number of total, reference memory and working memory errors. Promethazine, diphenhydramine and chlorphenilamine, having potent anti-muscarinic receptor properties, increased hippocampal theta power during radial maze performance at a dose of 20 mg/kg. On the other hand, triprolidine, which has weak anti-muscarinic receptor properties compared with other histamine H(1) receptor antagonists, decreased theta power at a dose of 35 mg/kg. These results suggest that anti-muscarinic receptor properties rather than anti-histamine H(1) receptor properties may affect hippocampal theta power during spatial memory deficit induced by promethazine, diphenhydramine and chlorphenilamine.

Authors+Show Affiliations

Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17884040

Citation

Masuoka, Takayoshi, et al. "Effects of Histamine H(1) Receptor Antagonists On Hippocampal Theta Rhythm During Spatial Memory Performance in Rats." European Journal of Pharmacology, vol. 576, no. 1-3, 2007, pp. 77-82.
Masuoka T, Mikami A, Yasuda M, et al. Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats. Eur J Pharmacol. 2007;576(1-3):77-82.
Masuoka, T., Mikami, A., Yasuda, M., Shinomiya, K., & Kamei, C. (2007). Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats. European Journal of Pharmacology, 576(1-3), 77-82.
Masuoka T, et al. Effects of Histamine H(1) Receptor Antagonists On Hippocampal Theta Rhythm During Spatial Memory Performance in Rats. Eur J Pharmacol. 2007 Dec 8;576(1-3):77-82. PubMed PMID: 17884040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats. AU - Masuoka,Takayoshi, AU - Mikami,Azusa, AU - Yasuda,Masa, AU - Shinomiya,Kazuaki, AU - Kamei,Chiaki, Y1 - 2007/08/23/ PY - 2007/03/24/received PY - 2007/07/24/revised PY - 2007/08/15/accepted PY - 2007/9/22/pubmed PY - 2008/3/7/medline PY - 2007/9/22/entrez SP - 77 EP - 82 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 576 IS - 1-3 N2 - The effects of histamine H(1) receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number of total errors and working memory errors at doses of 10 and 20 mg/kg, and a significant increase was also observed in reference memory errors at a dose of 20 mg/kg. Diphenhydramine and chlorphenilamine at a dose of 20 mg/kg and triprolidine at a dose of 35 mg/kg also caused significant increases in the number of total, reference memory and working memory errors. Promethazine, diphenhydramine and chlorphenilamine, having potent anti-muscarinic receptor properties, increased hippocampal theta power during radial maze performance at a dose of 20 mg/kg. On the other hand, triprolidine, which has weak anti-muscarinic receptor properties compared with other histamine H(1) receptor antagonists, decreased theta power at a dose of 35 mg/kg. These results suggest that anti-muscarinic receptor properties rather than anti-histamine H(1) receptor properties may affect hippocampal theta power during spatial memory deficit induced by promethazine, diphenhydramine and chlorphenilamine. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17884040/Effects_of_histamine_H_1__receptor_antagonists_on_hippocampal_theta_rhythm_during_spatial_memory_performance_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00928-4 DB - PRIME DP - Unbound Medicine ER -