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Neuropeptide FF (NPFF) reduces the expression of morphine- but not of ethanol-induced conditioned place preference in rats.
Peptides. 2007 Nov; 28(11):2235-42.P

Abstract

Neuropeptide FF (NPFF) has been described as an anti-opioid peptide. It plays a role in opioid antinociception, dependence and tolerance. Previous study has indicated that 1DMe ([D-Tyr(1), (NMe)Phe(3)]NPFF), a stable analog of NPFF, inhibits acquisition of the rewarding effect of morphine but not of ethanol in mice. The rewarding effects of these drugs were measured in the unbiased paradigm of conditioned place preference (CPP). The present study examines the influence of NPFF on the expression of morphine- and ethanol-induced CPP in the biased procedure in rats. Our experiments showed that NPFF, given intracerebroventricularly (i.c.v.) at the doses of 5, 10 and 20 nmol, inhibited the expression of morphine-induced CPP. NPFF gave itself, neither induced place preference nor aversion, although a tendency to aversive effect was seen at the highest dose of 20 nmol. NPFF did not indicate fear behavior in the elevated plus maze test, and did not disturb locomotor activity of rats. However, NPFF was unable to inhibit the expression of ethanol-induced CPP. Probably this effect is due to the fact that ethanol reward is a more complex process and apart from the role of opioids, there are other neurotransmitters also involved in this mechanism. These results suggest that NPFF is involved in the expression of morphine reward. Moreover, our study supports an anti-opioid character of this peptide.

Authors+Show Affiliations

Department of Pharmacology and Pharmacodynamics, Medical University School, Staszica 4, 20-081 Lublin, Poland. jolka.kotlinska@am.lublin.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17884254

Citation

Kotlinska, Jolanta, et al. "Neuropeptide FF (NPFF) Reduces the Expression of Morphine- but Not of Ethanol-induced Conditioned Place Preference in Rats." Peptides, vol. 28, no. 11, 2007, pp. 2235-42.
Kotlinska J, Pachuta A, Dylag T, et al. Neuropeptide FF (NPFF) reduces the expression of morphine- but not of ethanol-induced conditioned place preference in rats. Peptides. 2007;28(11):2235-42.
Kotlinska, J., Pachuta, A., Dylag, T., & Silberring, J. (2007). Neuropeptide FF (NPFF) reduces the expression of morphine- but not of ethanol-induced conditioned place preference in rats. Peptides, 28(11), 2235-42.
Kotlinska J, et al. Neuropeptide FF (NPFF) Reduces the Expression of Morphine- but Not of Ethanol-induced Conditioned Place Preference in Rats. Peptides. 2007;28(11):2235-42. PubMed PMID: 17884254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropeptide FF (NPFF) reduces the expression of morphine- but not of ethanol-induced conditioned place preference in rats. AU - Kotlinska,Jolanta, AU - Pachuta,Agnieszka, AU - Dylag,Tomasz, AU - Silberring,Jerzy, Y1 - 2007/08/17/ PY - 2007/06/08/received PY - 2007/08/10/revised PY - 2007/08/10/accepted PY - 2007/9/22/pubmed PY - 2008/2/27/medline PY - 2007/9/22/entrez SP - 2235 EP - 42 JF - Peptides JO - Peptides VL - 28 IS - 11 N2 - Neuropeptide FF (NPFF) has been described as an anti-opioid peptide. It plays a role in opioid antinociception, dependence and tolerance. Previous study has indicated that 1DMe ([D-Tyr(1), (NMe)Phe(3)]NPFF), a stable analog of NPFF, inhibits acquisition of the rewarding effect of morphine but not of ethanol in mice. The rewarding effects of these drugs were measured in the unbiased paradigm of conditioned place preference (CPP). The present study examines the influence of NPFF on the expression of morphine- and ethanol-induced CPP in the biased procedure in rats. Our experiments showed that NPFF, given intracerebroventricularly (i.c.v.) at the doses of 5, 10 and 20 nmol, inhibited the expression of morphine-induced CPP. NPFF gave itself, neither induced place preference nor aversion, although a tendency to aversive effect was seen at the highest dose of 20 nmol. NPFF did not indicate fear behavior in the elevated plus maze test, and did not disturb locomotor activity of rats. However, NPFF was unable to inhibit the expression of ethanol-induced CPP. Probably this effect is due to the fact that ethanol reward is a more complex process and apart from the role of opioids, there are other neurotransmitters also involved in this mechanism. These results suggest that NPFF is involved in the expression of morphine reward. Moreover, our study supports an anti-opioid character of this peptide. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/17884254/Neuropeptide_FF__NPFF__reduces_the_expression_of_morphine__but_not_of_ethanol_induced_conditioned_place_preference_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(07)00299-9 DB - PRIME DP - Unbound Medicine ER -